A5020604102- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Public Health in Brazil
- Advancements in Transdermal Drug Delivery
- Curcumin's Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Healthcare Regulation
- Crystallization and Solubility Studies
- Cytomegalovirus and herpesvirus research
- Microencapsulation and Drying Processes
- Herpesvirus Infections and Treatments
- Maternal and Neonatal Healthcare
- Transplantation: Methods and Outcomes
- Systemic Lupus Erythematosus Research
- Pharmacological Effects and Toxicity Studies
- Allergic Rhinitis and Sensitization
- Palliative and Oncologic Care
- Bee Products Chemical Analysis
- Protein purification and stability
- T-cell and Retrovirus Studies
- Chemistry Education and Research
- Renal Transplantation Outcomes and Treatments
- Health, Education, and Aging
- Pharmacology and Obesity Treatment
Universidade Estadual de Ponta Grossa
2011-2024
Universidade Federal de Santa Catarina
2009
Background: As part of the efforts to find natural alternatives for cancer treatment and overcome barriers cellular resistance chemotherapeutic agents, polymeric nanocapsules containing curcumin and/or methotrexate were prepared by an interfacial deposition preformed polymer method. Methods: Physicochemical properties, drug release experiments in vitro cytotoxicity these performed against Calu-3 lung cell line. Results: The colloidal suspensions showed suitable size (287 325 nm), negative...
This article aimed to improve the relative solubility and dissolution rate of ferulic acid (FA) by use spray-dried solid dispersions (SDs) in order ensure its vitro antioxidant potential enhance vivo anti-platelet effect. These SDs were prepared spray-drying at 10 20% drug concentration using polyvinylpyrrolidone K30 (PVP-K30), polyethylene glycol 6000 (PEG 6000) poloxamer-188 (PLX-188) as carriers. physical mixtures (PM) characterized SEM, XRPD, FTIR spectroscopy TGA analysis. Spray-dried...
Microparticles of poly(ε-caprolactone) (PCL) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) containing manidipine dihydrochloride (MAN) were successfully prepared by the simple emulsion/solvent evaporation method. All formulations showed loading efficiency rates greater than 80% average particle size less 8 μm. Formulations had spherical shape with smooth porous surface for PCL PHBV, respectively. According to Fourier-transform infrared spectroscopy, initial components not...
Adapalene (ADAP) is an important drug widely used in the topical treatment of acne. It a third-generation retinoid and provides keratolytic, anti-inflammatory, antiseborrhoic action. However, some adverse effects such as erythema, dryness, scaling have been reported with its commercial formula. In this sense, microencapsulation using polyesters can circumvent side lead to enhancement delivery into sebaceous glands. The goal work was obtain ADAP-loaded poly(ε-caprolactone) (PCL)...
Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application the often causes adverse side effects some patients. Hence, nanoencapsulation could be as an improved novel therapy mitigate and enhance bioavailability drug.Physicochemical properties, vitro release experiments, vivo anti-inflammatory activity studies were performed.TAC-loaded nanocapsules successfully prepared by interfacial deposition preformed...
Abstract Summary: Polymers derived from cyclodextrins show several biomedical applications. In this paper, six cross‐linked polyurethane networks based on β ‐cyclodextrin ( CD) or hydroxypropyl‐ (HP and polyethylene glycols (PEG 400, PEG 1500 4000) were synthesized by the usual two‐step polymerization method. The polymers characterized Fourier‐transformed infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) X‐ray diffraction (XRD). inclusion capacity was evaluated discoloration...
Curcumin (CUR) shows potential use for treating cancer. However, CUR has low solubility and reduced bioavailability, which limit its clinical effect. Therefore, the development of nanocarriers can overcome these problems ensure desired pharmacological In addition, it is mandatory to prove quality, efficacy, safety a novel nanomedicine be approved. that sense, this paper aimed (a) prepare CUR-loaded polyethylene glycol-poly(ε-caprolactone) nanocapsules; (b) validate an analytical method by...
The aim of this paper was to use chromatographic tools for validating an analytical method the tacrolimus (TAC) determination in polymeric nanocapsules and identifying drug degradation products after alkaline stress. A rapid Ultra-High-Performance Liquid Chromatography coupled with photo-diode array (UHPLC-PDA) successfully performed using following conditions: Shimadzu Shim-pack XR-ODS III C18 column (100 mm×2.00 mm, 2.2 μm), mobile phase consisting methanol acidified ultrapure water (89:11...
SUSTAINED RELEASE.This work reports the validation of an analytical UV spectrophotometric method to assay acyclovir in hydrophilic matrices (assay and dissolution studies).The was linear range between 2.5-20 µg mL -1 , presenting a good correlation coefficient ( r = 0,9999).Precision accuracy analysis showed low relative standart deviation (< 2.0 %) recoveries percentual (98.9-100 %).The procedure linear, accurate, robust.The is simple cheap.It does not use polluting reagents can be applied...
A hiperglicemia é uma ocorrência comum no ambiente hospitalar e está associada a desfechos negativos. Diabetes Mellitus tem alta prevalência entre os pacientes internados, o manejo da destes difere conduta ambulatorial. O uso de escala móvel como terapia isolada em com persistente contraindicado; entanto, muitos hospitais utilizam este esquema devido sua facilidade. trabalho teve objetivos descrever agrupar diferentes esquemas insulina utilizados hospital pelos diabéticos, traçar perfil...
Considerando a escassez de estudos sobre hipodermóclise como via administração em cuidados paliativos e importância melhorar qualidade vida dos pacientes, objetiva-se compilar analisar as informações disponíveis na literatura para fundamentar criação protocolos institucionais. Para tanto, procede-se uma revisão integrativa da literatura, com levantamento artigos publicados entre 2004 2024 nas bases dados MEDLINE SciELO. Desse modo, observa-se que, apesar regulamentação limitada medicamentos...
Com o envelhecimento populacional observa-se uma alta prevalência de doenças crônicas não transmissíveis, sendo frequente a hospitalização idosos devido ao agravo algumas destas patologias. É comum que, em algum momento durante internação hospitalar, esses pacientes utilizem antimicrobianos (ATB), cujo uso precisa ser adequadamente monitorado modo minimizar efeitos nocivos decorrentes deste tratamento. Dessa forma, monitorização da taxa filtração glomerular (TFG) é importante para detectar...