A5085069114- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Parasitic Infections and Diagnostics
- Parasite Biology and Host Interactions
- Urological Disorders and Treatments
- Indigenous Studies and Ecology
- Forensic and Genetic Research
- Echinoderm biology and ecology
University of Tartu
2014-2025
University of Zurich
2020-2025
Abstract Tapeworms of the species complex Echinococcus granulosus sensu lato ( s. l. ) are cause a severe zoonotic disease – cystic echinococcosis, which is listed among most parasitic diseases in humans and prioritized by World Health Organization. A stable taxonomy E. essential to medical veterinary communities for accurate effective communication role different this on human animal health. l . displays high genetic diversity has been divided into genotypes. Despite several decades...
SUMMARY Echinococcus granulosus is the causative agent of cystic echinococcosis. The disease a significant global public health concern and human infections are most commonly associated with E. sensu stricto (s. s.) genotype G1. objectives this study were to: (i) analyse genetic variation phylogeography s. G1 in part its main distribution range Europe using 8274 bp mtDNA; (ii) compare results those derived from previously used shorter mtDNA sequences highlight major differences. We sequenced...
Abstract Cystic echinococcosis (CE) is a severe parasitic disease caused by the species complex Echinococcus granulosus sensu lato. Human infections are most commonly associated with E. stricto (s.s.), comprising genotypes G1 and G3. The objective of current study was to provide first insight into genetic diversity phylogeography genotype Despite epidemiological importance genotype, it has remained poorly explored due ambiguity in definition genotype. However, recently demonstrated that long...
Echinococcus granulosus and E. multilocularis are tapeworm parasites of major medical veterinary importance, causing cystic alveolar echinococcosis, respectively. Both diseases listed among the most severe parasitic in humans, representing 2 17 neglected prioritised by World Health Organisation. However, little is known about role urban animals transmission both parasite species.A sensitive non-invasive genetic method was used to monitor infection dog faecal samples collected from an area...
Alveolar echinococcosis (AE) caused by Echinococcus multilocularis , is a severe zoonotic disease in humans. One of the major metacestode antigens E. Em2 or Em2(G11) native purified antigen. The antigen used for serological and histopathological diagnosis AE humans plays an important role parasite–host interactions. As mucin-type glycosylated protein, protein backbone has not been identified yet. We have targeted identification through mass spectrometry (LC-MS/MS) analysis result, we...
Cystic echinococcosis is a severe zoonotic disease caused by different species and genotypes belonging to the Echinococcus granulosus sensu lato (s.l.) complex. Among these, G6 G7 are second most common cause of human cystic echinococcosis. One very first steps towards understanding epidemiology study their genetic host diversity, population structure phylogenetic relationships. For this, we sequenced near-complete mitochondrial genomes (12,850 - 12,856 bp) 72 new samples from eight...
Cystic Echinococcosis (CE) caused by Echinococcus granulosus sensu lato (s.l.) is one of the most important parasitic zoonotic diseases in world and it represents an public health socio-economic concern. In Mediterranean basin, CE widespread endemic Italy, with major prevalence southern areas. Several studies have investigated domestic pigs, however, such data wild boars are scant. last decades boar population Italy has increased this ungulate could play role spreading wild. Here we report...
Alveolar (AE) and cystic echinococcosis (CE) are severe parasitic zoonoses caused by the larval stages of Echinococcus multilocularis E. granulosus sensu lato , respectively. A panel 7 monoclonal antibodies (mAbs) was selected against major diagnostic epitopes both species. The binding capacity mAbs to spp. excretory/secretory products (ESP) analyzed sandwich-ELISA, where mAb Em2G11 EmG3 detected in vitro extravesicular ESP s.s. These findings were subsequently confirmed detection...
Abstract Cystic echinococcosis is a socioeconomically important parasitic disease caused by the larval stage of canid tapeworm Echinococcus granulosus , afflicting millions humans and animals worldwide. The development vaccine (called EG95) has been most notable translational advance in fight against this animals. However, almost nothing known about genomic organisation/location family genes encoding EG95 related molecules, extent their conservation or functions. lack complete reference...
Abstract Echinococcus granulosus sensu lato is a group of tapeworm species known to cause cystic echinococcosis. Within this group, the canadensis cluster includes genotypes G8 and G10 that have predominantly sylvatic life cycle – transmission occurs between wild cervids wolves. Relatively few studies explored genetic variation elusive G10, their extent yet be investigated at complete mitochondrial (mt) genome level. The aim was explore these 2 in Europe using mtDNA sequences provide...
Abstract The metacestode of Echinococcus multilocularis is the etiological agent alveolar echinococcosis. stage used for research maintained in rodents by serial passages. In order to determine whether cryopreservation E. metacestodes would be suitable long-term maintenance and replace passages, isolates different geographic origin were cryopreserved 1984–1986. aim current study was test viability following (up 35 years) phylogenetic clades these belonged to. Cryopreserved tested vitro vivo...
Abstract Cystic echinococcosis (CE) is considered the most severe parasitic disease that ever affected human population in Iceland. Before start of eradication campaign 1860s, Iceland was a country with very high prevalence CE, approximately every fifth person infected. Eradication CE from by 1979 huge success story and served as leading example for other countries on how to combat such One Health problem. However, there no genetic information Echinococcus parasites before eradication. Here,...
Abstract There are no scientific data available on the occurrence of Echinococcus granulosus sensu lato ( s.l. ) cluster in definitive hosts (domestic dogs), intermediate livestock) nor humans Cape Verde. In this pilot study, environmental dog fecal samples n = 369) were collected around food markets, official slaughterhouses, as well home and small business slaughter spots 8 9 inhabited islands from Verde archipelago, between June 2021 March 2022. Additionally, during same period, 40 cysts...