A5002500936- Evolution and Genetic Dynamics
- Species Distribution and Climate Change
- Genetic diversity and population structure
- Endometrial and Cervical Cancer Treatments
- Animal Behavior and Reproduction
- Physiological and biochemical adaptations
- Oral microbiology and periodontitis research
- Management of metastatic bone disease
- Ovarian cancer diagnosis and treatment
- Plant and animal studies
- Animal Ecology and Behavior Studies
- Dental Radiography and Imaging
- Genetic and phenotypic traits in livestock
- Evolutionary Game Theory and Cooperation
- Ecology and Vegetation Dynamics Studies
- Dental Health and Care Utilization
- Renal and related cancers
- Genetics and Neurodevelopmental Disorders
- Obstructive Sleep Apnea Research
- Tree-ring climate responses
- HIV/AIDS oral health manifestations
- Fetal and Pediatric Neurological Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Dental Research and COVID-19
- Inflammatory Biomarkers in Disease Prognosis
University of Tübingen
2023-2025
University of Lausanne
2022-2023
University of Vienna
2020-2023
Swiss Federal Institute for Forest, Snow and Landscape Research
2016-2023
University of Zurich
1976-2022
Medical University of Vienna
2009-2022
Comprehensive Cancer Center Vienna
2018-2022
Ludwig-Maximilians-Universität München
2020
Universitätsklinik für Strahlentherapie
2020
Ecological Society of America
2020
Abstract Withstanding extinction while facing rapid climate change depends on a species’ ability to track its ecological niche or evolve new one. Current methods that predict climate-driven range shifts use modelling without eco-evolutionary dynamics. Here we present an forecasting framework combines with individual-based demographic and genetic simulations. Applying our approach four endemic perennial plant species of the Austrian Alps, show accounting for dynamics when predicting responses...
Abstract The ongoing increase in global temperature affects biodiversity, especially mountain regions where climate change is exacerbated. As sessile, long‐lived organisms, trees are challenged terms of adapting to rapid change. Here, we show that low rates allele frequency shifts Swiss stone pine ( Pinus cembra ) occurring near the treeline result high genomic vulnerability future warming, presumably due species’ long generation time. Using exome sequencing data from adult and juvenile...
Many species experience heterogeneous environments and adapt genetically to local condi- tions. The extent of such adaptation depends on a balance between divergent selection gene flow, but also other factors as phenotypic plasticity or the genetic architecture traits. Here, we explore role life history in this process. We develop quantita-tive genetics model run individual-based simulations contrast evolution short- long-lived species. show that varies with species' cycle how modulates...
Abstract The ability of three different oral hygiene devices to remove 2‐day‐old bacterial deposits was evaluated on 21 young adults with healthy periodontia. On buccal tooth surfaces, the cleaning effect a multitufted nylon brush superior that wooden toothpick or unwaxed denial floss. lingual as effective brush. visible portions proximal all were equally efficient. A combined exercise instruments together yielded significantly hotter results than did use each single device. Eight subjects...
Understanding how a species’ life history affects its capacity to cope with environmental changes is important in the context of rapid climate changes. Reinterpreting previous results from well-developed theoretical framework, we show that trade-off exists between ability genetically adapt long-term gradual and demographically resist short-term perturbations, causing variation vital rates. Surprisingly, this insight has not been made formally explicit before. Choosing archetypal histories...
Abstract Anticipating and preparing for the effect of environmental changes on biodiversity requires to understand predict both ecological evolutionary responses populations. Tools methods efficiently integrate these complex processes are lacking. We present genetically spatially explicit individual‐based simulation software Nemo‐age combining processes. has a strong emphasis modelling life histories. here provide methodology in species distribution given climate projections using ....
ObjectiveTo delineate a novel autosomal recessive multiple congenital anomaly-mental retardation (MCA-MR) syndrome in 2 female siblings of consanguineous pedigree and to identify the disease-causing mutation.Study designBoth were clinically characterized homozygosity mapping sequencing candidate genes applied. The contribution nonsense-mediated messenger RNA (mRNA) decay expression mutant mRNA fibroblasts healthy carrier control was studied by pyrosequencing.ResultsWe identified first...
While clines in environmental tolerance and phenotypic plasticity along a single species' range have been reported repeatedly are of special interest the context adaptation to changes, we know little about their evolution. Recent empirical findings ectotherms suggest that processes underlying dynamic ranges can give rise spatial differences within species. We used individual-based simulations investigate how evolve course three scenarios shifts expansions on gradients. found regions...
Abstract One of the largest causes fluctuations in size and structure populations is changes environment. In nature, these are often temporally autocorrelated strength direction autocorrelation can affect population dynamics. These effects mediated by complex, simultaneously occurring ecological evolutionary processes, such as phenotypic plasticity selection. Determining how processes interact to responses different life histories environmental paramount importance infer which taxa likely go...
In patch- or habitat-structured populations, different processes can favor adaptive polymorphism at scales. While spatial heterogeneity generate spatially disruptive selection favoring variation between patches, local competition lead to locally promoting within patches. So far, almost all theory has studied these two in isolation. Here, we use mathematical modeling investigate how resource and habitats influences the evolution of a consumer population where individuals compete finite...
Abstract Microsatellite DNA families ( MDF ) are stretches of that share similar or identical sequences beside nuclear simple‐sequence repeat nSSR motifs, potentially causing problems during marker development. Primers positioned within s can bind several times the genome and might result in multiple banding patterns. It is therefore common practice to exclude loci course Here, we propose an approach deal with primer‐binding sites by purposefully positioning primers detected repetitive...
Abstract Many species experience heterogeneous environments and adapt genetically to local conditions. The extent of such adaptation has been shown depend on a balance between divergent selection gene flow, but also other factors as phenotypic plasticity or the genetic architecture traits. Here, we explore role life history in this process. We develop quantitative genetics model run individual-based simulations contrast evolution short- long-lived species. show that does not have...
Abstract. A surgical technique to establish wide zones of attached mucosa was performed in 28 patients presenting with inadequate amounts gingiva. The clinical results the procedure were monitored over a period 2 years. Biometric assessment 112 mucogingival units immediately before and at 1, 3, 6, 24 months after surgery revealed that mean width gingiva changed from 1.1 mm 5.3 tissue (gingiva plus vestibular mucosa). surgically produced increase 4.9 ( P < 0.001) subsequent shrinkage 0.7...
Abstract We adopted a landscape-scale approach to analyze the genetic patterns (diversity, structure, and differentiation) of Marbled White ( Melanargia galathea ). This butterfly species is characteristic semi-dry grasslands, which have substantially declined in Switzerland during past decades. sampled individuals on regular grid established Biodiversity Monitoring program over five consecutive years, obtaining 1639 genotyped from 185 locations. Results showed that M. populations cluster...
Abstract In patch- or habitat-structured populations different processes can lead to diversity at scales. While spatial heterogeneity generates spatially disruptive selection favoring variation between patches, local competition locally promoting within patches. So far, almost all theory has studied these two in isolation. Here, we use mathematical modelling investigate how resource and habitats influences the evolution of a consumer population where individuals compete finite patches...