A5011929385- Microbial Natural Products and Biosynthesis
- Medicinal Plants and Neuroprotection
- Phytochemicals and Medicinal Plants
- Fungal Biology and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical synthesis and alkaloids
- Cancer Treatment and Pharmacology
- Microbial Metabolism and Applications
- Marine Sponges and Natural Products
- Enzyme Catalysis and Immobilization
- Catalysis for Biomass Conversion
- Synthetic Organic Chemistry Methods
- Nanoparticles: synthesis and applications
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Oxidative Organic Chemistry Reactions
- Analytical Chemistry and Chromatography
- Plant Pathogens and Fungal Diseases
- Phytochemistry and Bioactivity Studies
- Cholinesterase and Neurodegenerative Diseases
- Subcritical and Supercritical Water Processes
Institut de Chimie des Substances Naturelles
2015-2025
Centre National de la Recherche Scientifique
2013-2023
Université Paris-Saclay
2021-2022
Parkinson's disease is a neurodegenerative proteinopathy that primarily affects mesencephalic dopaminergic neurons. This depletion can be phenotypically reproduced in various experimental models through the administration of two neurotoxins: N-methyl-4-phenylpyridinium (MPP+) and 6-hydroxydopamine (6-OHDA). The mechanisms underlying cell death processes induced by these toxins remain subject debate. In this context, studies suggest oxidative-stress-related may contribute to dysfunction...
The three ayurvedic medicinal plants, Withania somnifera, Emblica officinalis, and Bacopa monnieri, were extracted by high-pressure static extraction using the Zippertex(®) technology. extracts mixed to reach quantifiable amounts of active compounds identified liquid chromatography-mass spectrometry (HPLC-MS) analysis. mixture was incubated with resting cells fungus Beauveria bassiana ATCC 7159. fermentation promoted fluidization starting dense mixture, while HPLC monitoring evidenced...
The bioconversion of Withania somnifera extract by the fungus Beauveria bassiana leads to cysteine and glutathione derivatives withaferin A at C-6 position. compounds were purified fully characterized 1D-NMR, 2D-NMR, HRMS analysis. derivative CR-777 was evaluated as a neuroprotective agent from damage caused different neurotoxins mimicking molecular symptoms in Parkinson´s disease (PD), including 1-methyl-4-phenylpyridinium (MPP+), 6-hydroxydopamine (6-OHDA), α-synuclein (α-Syn). CR-777,...
A series of furyl carbinols, which were directly obtained from a bio-sourced raw material, efficiently transformed into cyclopentenone derivatives in good yields and on large scale using the Zippertex technology under subcritical water conditions.
Fungal tetraketide pyrones possess important and potent bioactivities, but their detailed biosynthetic pathways are unknown synthetic routes to production lengthy. Here we investigated the fungal multiforisins compounds related islandic acid. Heterologous expression experiments yield high titres of these pathway intermediates. The results both elucidate offer a platform for total biosynthesis this class metabolites.
Abstract Herein, we describe the first total synthesis of trienylfuranol A, a fungal triene‐substituted tetrahydrofuran metabolite. The stereoselectivity chiral center bearing trienyl side chain was diastereodivergently controlled by addition nucleophilic species on substituted γ‐butyrolactone. Remarkably, C ‐nucleophilic or hydride onto oxocarbenium intermediate leads to opposite diastereoselectivity reported for Kishi Woerpel models. use Hantzsch ester (HEH) as organic donor has enabled us...