Background The Japanese National Immunization Program currently includes the pediatric 13valent pneumococcal conjugate vaccine (PCV13) to prevent infections. We aimed evaluate cost-effectiveness of 20-valent PCV (PCV20) as a versus PCV13.

A population survey of seasonality in six representative cities Japan was conducted using the Japanese version Seasonal Pattern Assessment Questionnaire (SPAQ). The questionnaires were given to 951 parents (male: female ratio 1 : age range 34‐59 years) high‐school students. Significant regional differences seasonal variations mood, length sleep, and weight observed; proportion individuals reporting high two northern significantly higher than that other areas. These results provide evidence...

Background The aim of this study was to evaluate the public health and economic impact COVID-19 booster vaccination with BNT162b2 in Japan during an Omicron-dominant period from early 2022.

Alopecia areata (AA) is a non-scarring hair loss disorder affecting approximately 2% of the global population. AA reported to have significant negative impact on emotional and psychological well-being patients. This study aimed evaluate health-related quality life (HRQoL) Japanese patients with in comparison population norms (national standard values for Japanese) using Short Form Health Survey 36 Item Version 2.0 (SF-36v2). The also access effect patients' daily lives proportion having...

Atopic dermatitis (AD) negatively affects patients' daily lives. Poor medication adherence is a major barrier to treatment success. However, factors causing poor are unclear. This study aimed identify associated with improvement of in Japanese patients AD and evaluate illness burden unmet medical needs for AD. We retrospectively analyzed Web-based questionnaire surveys conducted 2018 aged 15 years above who had been in- or outpatients within the past year from survey. Quality life using...

Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant clinical, economic, and human burden. The JAK1 Dermatitis Efficacy Safety (JADE) program's Phase 3 trials demonstrated that as treatment for moderate-to-severe AD in adults previous exposure to immunotherapy, abrocitinib showed superior efficacy safety compared standard of care (SoC), consisting topical corticosteroids. This study assessed the cost-effectiveness SoC versus alone this patient population Japan from...

Borna disease virus (BDV) infection has been suspected to be a possible etiological factor in human psychiatric disorders and recently chronic fatigue syndrome. Evidence of the correlation BDV with these remained unclear. Kagoshima is known one major areas which T-cell leukemia type 1 (HTLV-1) endemic; this first isolated retrovirus that causes adult neurological symptoms. The present study aimed clarify whether HTLV-1 infections are associated among Japanese patients. Subjects were 346...

Gold/iron oxide magnetic nanoparticles are hybrid containing a core of iron and surface colloidal gold, which allows for various biomaterials to be immobilized on the via gold. Here, we developed novel resonance (MR) imaging agent broaden MR tumor-imaging spectrum superparamagnetic (SPIO), e.g., Feridex, clinical diagnosing liver cancer. Au/Feridex was synthesized by electron beam irradiation, thiol-modified poly(ethylene glycol) (PEG-SH) easily conjugated its an Au−S bond without need any...

Alopecia area (AA) is a common autoimmune disorder, characterized by hair loss. Although its impact on quality of life fairly well understood, studies the economic AA are limited. The aim this study was to quantify personal and nationwide burden in Japan. Data were drawn from Adelphi Disease Specific Programme (DSP)™, real-world, cross-sectional survey with retrospective data collection, Japanese physicians patients AA. conducted 2021, before approval Janus kinase inhibitors for Physicians...

Objective: To evaluate healthcare resource use for respiratory syncytial virus (RSV) in Japan. Methods: Using JMDC and Medical Data Vision (MDV) claims databases, we retrospectively evaluated cost length of hospital/intensive care unit stays RSV-diagnosed cohorts infants (<12 months) older adults (OAs, ≥60 years). We analyzed the usage costs palivizumab infants. Results: Mean among those hospitalized were $2823 (USD); $2851; $6609 (¥131 [JPY]/$) JMDC-infant (n = 13,752); MDV-infant 22,142);...

To find a new anti-malarial medicine derived from natural resources, we examined the leaves of 13 common Japanese plants in vitro. Among them, leaf-extract Hydrangea macrophylla, flower, inhibited parasitic growth Plasmodium falciparum. The IC50 macrophylla leaf extract to falciparum was 0.18 microg/ml. NIH 3T3-3 cells, normal mouse cell line, 7.2 Thus, selective toxicity 40. For vivo test, inoculated berghei, rodent malaria parasite, ddY mice and administered (3.6 mg/0.2 ml) orally 3 times...

ABSTRACT Campylobacter hyointestinalis isolated from swine with proliferative enteritis often is considered to be pathogenic. While the precise virulence mechanisms of this species remain unclear, we have recently identified a cytolethal distending toxin ( cdt ) gene cluster in C. patient diarrhea (W. Samosornsuk et al., J Med Microbiol, 27 July 2015, http://dx.doi.org/10.1099/jmm.0.000145 ). However, sequences genes were found significantly different and products are immunologically...

Although Campylobacter jejuni and coli are the most common bacterial causes of human gastrointestinal diseases, other species also involved in animal infections. In this study, we developed a cytolethal distending toxin (cdt) gene-based PCR-RFLP assay for detection differentiation C. jejuni, coli, fetus, hyointestinalis, lari, helveticus upsaliensis. Previously designed primers, which can amplify cdtB gene were used detecting seven differentiating between them by restriction digestion. The...

Japan will be transitioning from the free-of-charge COVID-19 vaccination program to annual periodic under a national immunization for old adults and high-risk patients 2024 fall/winter season. The policy transition including out-of-pocket payment requirement may discourage vaccination, leading lower rate. This study aimed estimate impact of varying rates with BNT162b2 mRNA vaccine on economics public health in an illustrative prefecture which administers promotes program, using budget analysis.

Increasing numbers of Campylobacter hyointestinalis have been isolated from humans and animals with gastroenteritis, although the virulence mechanism this species remains largely unknown. Here, we show that C. a patient diarrhoea in Thailand produced novel variant cytolethal distending toxin (CDT). Sequencing 13 965 bp genomic region carrying genes coding for Ch-CDT revealed three ORFs 798, 804 537 bp, which code Ch-CdtA, Ch-CdtB Ch-CdtC subunits, respectively. The deduced amino acid...

The 23-valent pneumococcal polysaccharide vaccine (PPSV23) is used in the Japanese National Immunization Program for older adults and with increased risk disease, however, disease incidence associated burden remain high. We evaluated cost-effectiveness of conjugate vaccines (PCVs) aged 65 years high-risk 60-64 Japan.

In this study, we devised a multiplex PCR assay based on the gene of cytolethal distending toxin (cdt) B subunit to simultaneously detect and discriminate Campylobacter jejuni, C. fetus, coli, upsaliensis, hyointestinalis, lari. Species-specific products were successfully obtained from all 38 12 39 22 24 7 lari strains tested. On other hand, no specific campylobacters bacterial species tested (41 in total). The proposed is valuable tool for detection descrimination 6 major species, that are...

Abstract Aim PF‐06438179/GP1111 (PF‐SZ‐IFX) is a biosimilar of reference infliximab (Remicade ® ). This analysis compared the efficacy PF‐SZ‐IFX and sourced from European Union (IFX‐EU) in patient subgroups randomized, comparative study versus IFX‐EU. Methods Patients with rheumatoid arthritis were randomized 1:1 to (n = 324) or IFX‐EU 326); drug (3 mg/kg) was administered intravenously at weeks 0, 2, 6, then every 8 thereafter. Subgroup analyses endpoints such as American College...

Respiratory syncytial virus (RSV) is one of the major causes respiratory tract infections among children. Until recently, monoclonal antibody palivizumab was only RSV prophylaxis available in Japan. In 2024, bivalent prefusion F protein-based (RSVpreF) vaccine approved for prevention infection infants by active immunization pregnant women. this study, we assessed cost-effectiveness a combined strategy RSVpreF and Japanese setting. Using Markov model, evaluated prevented cases deaths...