A5014660544- Lung Cancer Treatments and Mutations
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- Lung Cancer Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Peptidase Inhibition and Analysis
- Escherichia coli research studies
- Lung Cancer Research Studies
- DNA and Nucleic Acid Chemistry
- Osteoarthritis Treatment and Mechanisms
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Cardiac electrophysiology and arrhythmias
- Silk-based biomaterials and applications
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Colorectal Cancer Treatments and Studies
- Nanofabrication and Lithography Techniques
- Cardiac tumors and thrombi
NTT Medical Center
2015-2025
Ajinomoto (Japan)
2020-2024
Suzuki (Japan)
2020-2024
The University of Tokyo
2011-2022
Chongqing University
2022
Tsinghua University
2022
University of Crete
2022
FORTH Institute of Computer Science
2022
National Institute of Infectious Diseases
1989-2020
Ajinomoto (United States)
2020
Telomeric repeat-containing RNA (referred to as TERRA), a noncoding molecule, has recently been found in mammalian cells. The detailed structural features and function of the TERRA at human chromosome ends remain unclear, although this molecule may be key component telomere machinery. In present studies, we investigated living Using light-switching pyrene probe, that forms parallel G-quadruplex structure cells, providing vivo evidence for presence RNA. Furthermore, imaging experiments...
Abstract Hepatocyte growth factor (HGF) receptor, also known as Met, is a member of the receptor tyrosine kinase family. The Met–HGF interaction regulates various signalling pathways involving downstream kinases, such Akt and Erk. Met activation implicated in wound healing tissues via multiple biological responses triggered by above-mentioned cascade. Here we report development artificial Met-activating dimeric macrocycles. We identify Met-binding monomeric macrocyclic peptides means RaPID...
Antibody–drug conjugates (ADCs) combine cytotoxic payloads with monoclonal antibodies through chemical linkers. Finding linkers that both enhance circulatory stability and enable effective tumor payload release remains a challenge. The conventional valine-citrulline (Val-Cit) linker is associated several inherent drawbacks, including hydrophobicity-induced aggregation, limited drug–antibody ratio (DAR), premature release. This study introduces an exolinker approach, repositioning the...
Immune-checkpoint inhibitors (ICIs) are effective against advanced non-small cell lung cancer (NSCLC). However, whether the efficacy and safety of ICI treatment in elderly patients similar to those younger is unclear. This study was designed address this question.We enrolled who received monotherapy Japan between December 2015 2017; ≥75 years age comprised group. We compared with explored prognostic factors patients.We 676 patients; 137 (20.3%) were assigned The median groups 78 (range,...
A series of aryl and alkyl O-beta-D-xylosides their analogues with S, NH or CH2 in the glycosidic linkage were prepared examined for ability to act as artificial chain initiators chondroitin (dermatan) sulphate synthesis embryonic chick cartilage, foetal rat skin 6-week-old-rat aorta under conditions where normal protein-core was inhibited by cycloheximide. For all these tissues culture, phenyl O-beta-D-xyloside beta-D-thioxyloside clearly more effective than corresponding N-xyloside...
Proteoglycan Type H formed by incubation of chick embryo epiphyseal cartilages with [14C]glucosamine altered its buoyant density as the concentration SO4(2-) in medium was lowered from 300 to 0 microM. At highest concentration, labeled product essentially identical unlabeled proteoglycan (i.e. molecules already preformed ovo) respect and hyaluronic acid-binding activity. With decreasing medium, products showed a gradual decrease no apparent change This directly related average sulfation...
A simple preparation of high drug-loaded ferritin nanomedicines was demonstrated. By mixing and a drug, an electrostatic potential with small cavity facilitated the passage deposition drug in cavity.
Chromosomal rearrangements of the RET (rearranged during transfection) gene are detected in approximately 1-2% non-small cell lung cancers (NSCLC) and have function as oncogenic driver genes. Selpercatinib is a highly effective inhibitor for RET-rearranged patients with NSCLC shows mostly tolerable adverse events. However, hypertension, aspartate aminotransferase increase, alanine increase most common events, dose modification or discontinuation required occasionally. Here, we describe case...
Chondroitin sulfate biosynthesis was studied in embryonic chicken sternum, with particular attention paid to the effect of environmental (SOd2-) concentration on structure newly formed chondroitin sulfate. Sternal cartilages were labeled vitro [3H]glucosamine presence varying concentrations inorganic sulfate, and sulfates studied. At higher than 30 pM, product found a peak centered position standard (fully sulfated) when fractionated DEAE-cellulose column by elution linear gradient NaCl....
Peptide modification is a popular strategy for developing an active targeting lipid nanoparticle (LNP). In modifying the surface of LNP with peptide, sequence and structure peptide strongly affects formation LNP. Specifically, high hydrophobicity can induce coarsening aggregation attempt to prevent this from occurring, we incorporated monoacyl diacyl group-conjugated poly(ethylene glycol) (PEG) into We previously developed original LNP, multifunctional envelope type nanodevice (MEND)...
Abstract Durvalumab has been administered to patients with unresectable stage III non‐small cell lung cancer (NSCLC). However, it remains unclear whether durvalumab benefits these epidermal growth factor receptor (EGFR) mutation. We conducted a retrospective, multicenter study of EGFR mutation who received chemoradiotherapy (CRT) between June 2018 and March 2021. assessed patient characteristics, efficacy durvalumab, safety before after targeted therapy. collected data on total 673 patients,...
Abstract Background Selecting pembrolizumab monotherapy (MONO) or plus platinum‐based chemotherapy (COMB) for patients with nonsmall cell lung cancer (NSCLC) and high programmed death‐ligand 1 (PD‐L1) expression is an important issue in clinical practice. We previously conducted a retrospective multicenter observational study of NSCLC PD‐L1 who received MONO COMB as first‐line treatment. Here, we report updated data evaluate the long‐term outcomes. Methods performed 298 treatment between...
Two distinct regions required for both contact hemolysis and entry into LLC-MK2 cells were cloned Escherichia coli from the Shigella sonnei form I plasmid, pSS120. The first region was an E. HB101 strain containing noninvasive Tn1 insertion mutants of expression ipa (invasion plasmid antigen) gene products restored. carrying then transformed lacking additional DNA fragments same recipient on compatible vectors. Five these double transformants found to be positive activity. Restriction...
RNA-mediated gene regulation and expression are critically dependent on both nucleic acid architecture recognition. We present a novel mechanism for the of through direct RNA-RNA interactions between small RNA mRNA in human cells. Using reporters containing G-rich sequences 5'-untranslated region (5'-UTR), coding region, or both, we showed that RNAs bind to reporter mRNAs form an intermolecular G-quadruplex can inhibit translation living combination circular dichroism (CD) RNase footprinting...
The development of a specific, effective method for the delivery therapeutics including small molecules and nucleic acids to tumor tissue remains be solved. Numerous types lipid nanoparticles (LNPs) have been developed in attempts achieve this goal. However, LNPs are probably not taken up by target cells because cancer-targeting typically modified with poly(ethylene glycol) (PEG), which inhibits cellular uptake LNPs, passively accumulate via enhanced permeability retention (EPR) effect. It...
Abstract Osimertinib is a standard of care therapy for previously untreated epidermal growth factor receptor mutation-positive non-small cell lung cancer. However, limited data exist regarding the efficacy and safety osimertinib as first-line elderly patients aged 75 years or older. To assess potential clinical benefits in this population, retrospective multi-institutional observational study included 132 with cancer (age ≥ years), who received treatment. The proportion 1-year...