A5042993346- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Occupational and environmental lung diseases
- Cancer Research and Treatments
- Cell death mechanisms and regulation
- Enzyme Structure and Function
- Pneumonia and Respiratory Infections
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Histone Deacetylase Inhibitors Research
- Blood transfusion and management
- Proteoglycans and glycosaminoglycans research
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Rural development and sustainability
- Antimicrobial Resistance in Staphylococcus
- Phenomenology and Existential Philosophy
- COVID-19 and healthcare impacts
- Protein Degradation and Inhibitors
University of California, Davis
2016-2024
New York Proton Center
2019-2022
Cornell University
2012-2021
Weill Cornell Medicine
2021
University of California Davis Medical Center
2018
Presbyterian Hospital
2012
Scott & White Memorial Hospital
2008-2010
Texas A&M Health Science Center
2008-2010
Mitchell Institute
2009
Temple College
2008-2009
AbstractMeosthelioma is a neoplasm of the pleura that currently incurable by conventional therapies. Previously, we demonstrated mesothelioma overexpresses BCL-XL, an anti-apoptotic member BCL-2 family. In addition, have shown down-regulation BCL-XL using antisense oligonucleotide engenders apoptotic cell death in vitro and vivo. The purpose this study to evaluate efficacy bcl2/bcl-xl inhibitor, 2-methoxy antimycin A3, inducing apoptosis increasing chemo-sensitivity Several bcl-xl...
Bortezomib, a proteasome-specific inhibitor, has emerged as promising cancer therapeutic agent. However, development of resistance to bortezomib may pose challenge effective anticancer therapy. Therefore, characterization cellular mechanisms involved in and strategies overcome this represent important steps the advancement bortezomib-mediated therapy.The present study reports I-45-BTZ-R, bortezomib-resistant cell line, from bortezomib-sensitive mesothelioma line I-45. I-45-BTZ-R cells showed...
Bcl-xL functions as a dominant regulator of apoptotic cell death and is implicated in chemotherapeutic resistance malignant pleural mesothelioma (MPM). Mesothelioma lines demonstrate increasing levels resistant clones are selected vitro. Moreover, upon introduction antisense oligonucleotides specific to mRNA, MPM cells sensitized agents. Here we describe the therapeutic effects novel combination therapy, oligonucleotide (ASO 15999) cisplatin, on vitro vivo; addition, efficacy ASO 15999...
Streptococcus pneumoniae open reading frame SP0082 encodes a surface protein that contains four copies of novel conserved repeat domain bears no significant sequence similarity to proteins known function. Homologous sequences from other streptococci contain two six these repeats, designated the SSURE (streptococcal repeat) domain. To investigate functional role(s) this domain, third has been expressed in Escherichia coli, purified homogeneity and characterized by biochemical immunological...
Streptococcus pneumoniae open reading frame SP1492 encodes a surface protein that contains novel conserved domain similar to the repeated fragments of mucin-binding proteins from lactobacilli and lactococci. To investigate functional role(s) this its potential adhesive properties, surface-exposed region was expressed in Escherichia coli, purified homogeneity, partially characterized by biophysical immunological methods. Circular dichroism sedimentation measurements confirmed is an all-beta...
Pneumococcal surface protein A (PspA) is an antigenic variable vaccine candidate of Streptococcus pneumoniae. Epitope similarities between PspA from the American strain Rx1 and Norwegian clinical isolates were studied using specific monoclonal antibodies (mAbs) made against strains. Using recombinant PspA/Rx1 fragments immunoblotting epitopes for mAbs mapped to two regions amino acids, 1–67 67–236. The discovered visualized by modelling PspA:Fab part mAb in three dimensions. Flow cytometric...
Abstract Purpose of the Review Anemia in critically ill is both insidious and highly prevalent; has been implicated poor outcomes patients with recovering from critical illness. Patient-oriented approaches to blood management (PBM) are gaining momentum have widespread applications as a superior approach anemia. The volume publications pertaining PBM dramatically increased past 4 years, warranting further review emerging paradigms ICU. Recent Findings IV iron alone conjunction erythropoietin...
The solution of the common quadratic which is usually written is, when expanded, This expansion will be found to work operator each term being derived from its predecessor by this operator's agency, so that whole may