A5021940072- HIV/AIDS drug development and treatment
- Phytochemistry and Biological Activities
- Synthesis and Catalytic Reactions
- Flavonoids in Medical Research
- Biochemical and Molecular Research
- Synthesis and biological activity
- Enzyme function and inhibition
- HIV Research and Treatment
- Cancer Mechanisms and Therapy
- Pneumocystis jirovecii pneumonia detection and treatment
Leibniz Institute of Plant Biochemistry
2024
Stellenbosch University
2016-2022
Hypoxia in tumors contributes to chemotherapy resistance, worsened by acidosis driven carbonic anhydrases (
The therapeutic toxicity and resistance to currently available treatment options are major clinical challenges for the management of lung cancer. As a novel strategy, we synthesized analogues known flavonol, fisetin, which has shown anti-tumorigenic potential against cancer in cell culture with no adverse effects animal models. We studied synthetic fisetin their anti-cancer cells, mice efficacy xenograft model. Brominated were screened on viability A549 H1299 three (3a, 3b, 3c), showed...