A5045342975- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Biochemical Analysis and Sensing Techniques
- Neural dynamics and brain function
- Retinal Development and Disorders
National Institute of Mental Health
2020-2024
Circadian (United States)
2023-2024
National Institutes of Health
2021-2022
University of Washington
2020
Light regulates daily sleep rhythms by a neural circuit that connects intrinsically photosensitive retinal ganglion cells (ipRGCs) to the circadian pacemaker, suprachiasmatic nucleus. Light, however, also acutely affects in circadian-independent manner. The circuits involving acute effect of light on remain unknown. Here we uncovered drives this response, independent nucleus, but still through ipRGCs. We show ipRGCs substantially innervate preoptic area (POA) mediate mice. Consistently,...
Exposure to irregular lighting schedules leads deficits in affective behaviors. The retino-recipient perihabenular nucleus (PHb) of the dorsal thalamus has been shown mediate these effects mice. However, mechanisms how light information is processed within PHb remains unknown. Here, we show that contains a distinct cluster GABAergic neurons receive direct retinal input. These are part larger inhibitory network composed thalamic reticular and zona incerta, known modulate thalamocortical...
Dopamine release in striatal circuits, including the nucleus accumbens (NAc), tracks separable features of reward such as motivation and reinforcement. However, cellular circuit mechanisms by which dopamine receptors transform into distinct constructs remain unclear. Here, we show that D3 receptor (D3R) signaling NAc drives motivated behavior regulating local microcircuits. Furthermore, D3Rs co-express with D1 (D1Rs), regulate reinforcement, but not motivation. Paralleling dissociable roles...
Abstract The temporal distribution of sleep stages is critical for the study function, regulation, and disorders in higher vertebrates. This typically determined polysomnographically. In laboratory rodents, scoring electrocorticography (ECoG) electromyography (EMG) recordings usually performed manually, where 5-10 second epochs are categorized as one three specific stages: wakefulness, rapid-eye-movement (REM) non-REM (NREM) sleep. process laborious, time-consuming, particularly impractical...