A5033816507- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Traumatic Brain Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- S100 Proteins and Annexins
- Circadian rhythm and melatonin
- Advanced Fluorescence Microscopy Techniques
- Adrenal Hormones and Disorders
- Retinal Development and Disorders
- Hormonal Regulation and Hypertension
- Pain Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Mitochondrial Function and Pathology
- Photoreceptor and optogenetics research
National Institute of Mental Health
2021-2025
National Institutes of Health
2021-2025
Pontificia Universidad Católica de Chile
2016-2022
Synaptic Research (United States)
2022
Université Laval
2020
Medical University of South Carolina
2020
Yale University
2020
Louisiana State University Health Sciences Center New Orleans
2020
Abstract The medial prefrontal cortex (mPFC) controls behavior via connections with limbic excitatory afferents that engage various inhibitory motifs to shape mPFC circuit function. dynorphin (Dyn) / kappa-opioid receptor (KOR) system is highly enriched in the mPFC, and its dysregulation implicated neuropsychiatric disorders. However, it unclear how Dyn KOR modulates circuits are integral for information processing behavioral control. Here, we provide a circuit-based framework wherein...
Exposure to irregular lighting schedules leads deficits in affective behaviors. The retino-recipient perihabenular nucleus (PHb) of the dorsal thalamus has been shown mediate these effects mice. However, mechanisms how light information is processed within PHb remains unknown. Here, we show that contains a distinct cluster GABAergic neurons receive direct retinal input. These are part larger inhibitory network composed thalamic reticular and zona incerta, known modulate thalamocortical...
Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has been implicated mediating negative affect and mal-adaptive behaviors induced by severe threats is expressed limbic circuits, including the vmPFC. However, there critical knowledge gap our understanding how vmPFC Dyn-expressing neurons Dyn transmission detect regulate expression...
Early life adversity can disrupt development leading to emotional and cognitive disorders. This study investigated the effects of social isolation after weaning on anxiety, body weight locomotion, extracellular dopamine (DA) glutamate (GLU) in nucleus accumbens (NAc) their modulation by corticotropin releasing factor receptor 1. On day weaning, male rats were housed singly or groups for 10 consecutive days. Anxiety-like behaviors assessed an elevated plus maze (EPM) open field test (OF)....
Dopamine release in striatal circuits, including the nucleus accumbens (NAc), tracks separable features of reward such as motivation and reinforcement. However, cellular circuit mechanisms by which dopamine receptors transform into distinct constructs remain unclear. Here, we show that D3 receptor (D3R) signaling NAc drives motivated behavior regulating local microcircuits. Furthermore, D3Rs co-express with D1 (D1Rs), regulate reinforcement, but not motivation. Paralleling dissociable roles...
Abstract Traumatic brain injury (TBI) is a risk factor for neurodegeneration, however little known about how different neuron types respond to this kind of injury. In study, we follow neuronal populations over several months after single mild TBI (mTBI) assess long ranging consequences at the level single, transcriptionally defined classes. We find that stress responsive Activating Transcription Factor 3 (ATF3) defines population cortical neurons mTBI. show activate ATF3 upregulate...
Basolateral amygdalar projections to the prefrontal cortex play a key role in modulating behavioral responses stress stimuli. Among different neuromodulators known impact basolateral amygdalar-prefrontal transmission, corticotrophin releasing factor (CRF) is of particular interest because its anxiety and stress-associated behaviors. While CRF type 1 receptor (CRFR1) has been involved functioning, participation 2 (CRFR2) synaptic transmission remains unclear.Immunofluorescence anatomical...
One manner in which G protein-coupled receptors potentiate, increase, and change their functionality is through the formation of heteromers a specific cellular context. Previously, we have shown that dopamine D1 receptor (D1R) corticotropin releasing factor type-2α (CRF2α) heteromerize HEK293T cells, enabling D1R to mobilize intracellular calcium response agonists. In this study, further investigated pharmacological properties CRF2α-D1R heteromer consequences heteromerization signaling...
Adversity is particularly pernicious in early life, increasing the likelihood of developing psychiatric disorders adulthood. Juvenile and adult rats exposed to social isolation show differences anxiety-like behaviors significant changes dopamine (DA) neurotransmission nucleus accumbens (NAc). Brain response stress partly mediated by corticotropin-releasing factor (CRF) system, composed CRF its two main receptors, CRF-R1 CRF-R2. In NAc shell rats, induces behavior local DA balance. However,...
Corticotrophin releasing factor (CRF) and its related peptides differentially bind to CRF receptors modulate stress-related behaviors. comprise two G-Protein Coupled Receptors (GPCR), type-1 (CRF1) type-2 (CRF2). CRF2 encompasses three spliced variants in humans, alpha (CRF2α), beta (CRF2β) gamma (CRF2γ), which differ their N-terminal extracellular domains expression patterns. Previously, we showed that CRF2α form a heteromeric protein complex with dopamine D1 (D1R), leading changes the...
Basolateral amygdala (BLA) excitatory projections to medial prefrontal cortex (PFC) play a key role controlling stress behavior, pain, and fear. Indeed, stressful events block synaptic plasticity at the BLA-PFC circuit. The responses involve action of corticotrophin releasing factor (CRF) through type 1 2 CRF receptors (CRF1 CRF2). Interestingly, it has been described that dopamine receptor (D1R) peptide have modulatory transmission. However, participation CRF1 CRF2 in transmission still is...
Corticotropin-releasing factor (CRF) receptors CRF-R1 and CRF-R2 are differentially distributed in body tissues, although they respond to stimuli due their association with different signaling pathways, both have a fundamental role the response adaptation stressful stimuli. Here, we summarize reported data on forms of regulation as well subcellular localization. Although presence R1 has been described at pre- postsynaptic sites, R2 is mainly associated densities. Different studies provided...
Summary The medial prefrontal cortex (mPFC) controls emotional behaviors and cognition via connections with limbic excitatory afferents that engage various intra-mPFC inhibitory motifs mPFC dynorphin (Dyn) / kappa-opioid receptor (KOR) system regulates affect is implicated in neuropsychiatric disorders. However, it’s unclear how neuropeptides the mPFC, including Dyn KOR system, control circuit integral information processing. Here, we provide a circuit-based framework wherein selective...