A5004349056- Sexual Differentiation and Disorders
- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Growth Hormone and Insulin-like Growth Factors
- Gut microbiota and health
- Dermatological and Skeletal Disorders
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Ovarian function and disorders
- Pancreatic function and diabetes
- Probiotics and Fermented Foods
- Skin and Cellular Biology Research
- Advanced Chemical Sensor Technologies
- Childhood Cancer Survivors' Quality of Life
- IL-33, ST2, and ILC Pathways
- Adrenal and Paraganglionic Tumors
- Metabolism, Diabetes, and Cancer
- Dupuytren's Contracture and Treatments
- Biliary and Gastrointestinal Fistulas
- Hedgehog Signaling Pathway Studies
- Nuclear Structure and Function
- Blood properties and coagulation
Limassol General Hospital
2019-2023
University of Cyprus
2023
Teva Pharmaceuticals (Australia)
2019-2022
Cyprus Institute of Neurology and Genetics
2010-2017
University of Nicosia
2016
University of Manchester
2006-2013
Polycystic ovary syndrome (PCOS) is a very common endocrine condition in women India. Gut microbiome alterations were shown to be involved PCOS, yet it remarkably understudied Indian who have higher incidence of PCOS as compared other ethnic populations. During the regional screening program among young women, we recruited 19 drug naive with and 20 control at Sher-i-Kashmir Institute Medical Sciences, Kashmir, North We profiled gut faecal samples by 16S rRNA sequencing included 40/58...
Commencing in December 2019 with the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), three years disease (COVID-19) pandemic have transpired. The virus has consistently demonstrated a tendency for evolutionary adaptation, resulting mutations that impact both immune evasion and transmissibility. This ongoing process led to successive waves infections. study offers comprehensive assessment spanning genetic, phylogenetic, phylodynamic, phylogeographic dimensions,...
The onset of puberty is influenced by the interplay stimulating and restraining factors, many which have a genetic origin. Premature activation GnRH secretion in central precocious (CPP) may arise either from gain-of-function mutations KISS1 KISS1R genes or loss-of-function manner MKRN3 gene leading to deficiency.To explore causes responsible for CPP potential role RING finger protein 3 (MKRN3) gene.We investigated sequence variations intronless Sanger sequencing entire 507 amino acid coding...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 resulted the disease (COVID-19) pandemic, which has had devastating repercussions for public health. Over course this virus continuously been evolving, resulting new, more infectious variants that have frequently led to surges new SARS-CoV-2 infections. In present study, we performed detailed genetic, phylogenetic, phylodynamic and phylogeographic analyses examine epidemic Cyprus using 2352...
Current knowledge on the capacity of plastics as vectors microorganisms and their ability to transfer between different habitats (i.e. air, soil river) is limited. The objective this study was characterise evolution bacterial community adhered environmental [low-density polyethylene (LDPE)] across environments from point use receiving environment destination in sea. took place a typical Mediterranean intermittent river basin Larnaka, Cyprus, characterised by large greenhouse area whose...
<i>Background/Aim:</i> To determine the mutations in <i>CYP21A2</i> gene Greek-Cypriots with congenital adrenal hyperplasia (CAH) and attempt a genotype-phenotype correlation. <i>Subjects Methods:</i> Molecular analysis was performed by multiplex ligation-dependent probe amplification direct sequencing of PCR products 32 CAH patients. <i>Results:</i> The most frequent genetic defect classic salt-wasting simple virilizing forms IVS2-13A/C>G...
Congenital adrenal hyperplasia ( CAH ) due to 21‐hydroxylase deficiency (21‐ OHD is a common autosomal recessive disorder caused by mutations in the CYP21A2 gene. The carrier frequency of has been estimated be 1:25 1:10 on basis newborn screening. main objective this study was determine Cypriot population Three hundred unrelated subjects (150 males and 150 females) from general Cyprus were screened for gene its promoter. genotype analysis identified six different mutants revealed 9.83% with...
The objective was to seek evidence on the prevalence and consequences of heterozygous CYP21A2 mutations in girls, adolescent, adult females with clinical manifestation androgen excess.The study included 64 girls diagnosed premature adrenarche (PA) childhood 141 hyperandrogenemia manifested adolescence or adulthood. Direct DNA sequencing multiplex ligation-dependent probe amplification analysis were used identify gene.(1) Thirty-four patients nonclassical-congenital adrenal hyperplasia...
Heterozygosity for CYP21A2 mutations in females is possibly related to increased risk of developing clinical hyperandrogenism. The present study was designed seek evidence on the phenotype-genotype correlation female children, adolescents, and women with variants 3′UTR region gene. Sixty-six patients out 169 were identified as carriers mutations. Higher values stimulated 17 hydroxyprogesterone (17-OHP) levels found p.Val281Leu mutation compared other (mean: 24.7 nmol/l versus 15.6 nmol/l)....
Familial Mediterranean fever (FMF) is caused by mutations in the MEFV gene and spectrum of among Greek–Cypriots with FMF-related symptoms was examined. Sequence analysis for exons 2, 3, 5, 10 performed a cohort 593 patients. A total 70 patients carried homozygote or compound heterozygote state, 128 were identified one mutation 395 had no mutations. Of 268 alleles, p.Val726Ala (27.61%) most frequent followed p.Met694Val (19.40%). The missense p.Arg761His (3.73%) p.Ala744Ser (2.24%) as rarest....