A5091590002- Gene Regulatory Network Analysis
- Advanced Mathematical Modeling in Engineering
- Blood Pressure and Hypertension Studies
- Advanced Differential Equations and Dynamical Systems
- Computational Drug Discovery Methods
- HIV Research and Treatment
- Nonlinear Partial Differential Equations
- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Microbial Metabolic Engineering and Bioproduction
- Nonlinear Dynamics and Pattern Formation
- Advanced Thermodynamics and Statistical Mechanics
- Spacecraft and Cryogenic Technologies
- Immune Cell Function and Interaction
- Quantum chaos and dynamical systems
- Mathematical and Theoretical Epidemiology and Ecology Models
- Protein Structure and Dynamics
- HIV, Drug Use, Sexual Risk
- Single-cell and spatial transcriptomics
- Food Security and Health in Diverse Populations
- Urinary Tract Infections Management
- Electoral Systems and Political Participation
- Surface Modification and Superhydrophobicity
- Mathematical Biology Tumor Growth
- Cytomegalovirus and herpesvirus research
University of California, San Francisco
1992-2025
National Center for Chronic Disease Prevention and Health Promotion
2025
Centers for Disease Control and Prevention
2025
Inova Fairfax Hospital
2024
Office of Infectious Diseases
2022
San Francisco AIDS Foundation
1994-2021
University of Waterloo
2001-2018
Duke University
2018
Brooklyn College
2017
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015
We examined the prevalence and correlates of condom use in a community-based sample unmarried heterosexual gay/bisexual Whites, Blacks, Hispanics (aged 20 to 44 years) San Francisco (n = 1229). Only 9% males reported always using condoms, fewer those with multiple sexual partners (6%) condoms compared monogamous relationships (12%). Much higher proportions men (48%). Racial differences were observed only among women. Sexual communication enjoyment value consistent across gender orientation,...
Clinical pharmacology studies that describe the pharmacokinetics and pharmacodynamics of drugs in pregnant women are critical for informing on safe effective use during pregnancy. That being said, multiple factors have hindered ability to study patients. These include concerns maternal fetal safety, ethical considerations, difficulty designing appropriate trials assess objectives, funding limitations. This document summarizes recommendations a panel experts convened by Division Microbiology...
On command control of gene expression in time and space is required for the comprehensive analysis key plant cellular processes. Even though some chemical inducible systems showing satisfactory induction features have been developed, they are inherently limited terms spatiotemporal resolution may be associated with toxic effects. We describe here first synthetic light-inducible system targeted plants. For this purpose, we applied an interdisciplinary biology approach comprising mammalian...
To investigate the patterns of electrolyte abnormalities resulting from thiazide administration and whether they cause ventricular arrhythmias, to help resolve controversy over clinicians should routinely prescribe potassium-conserving therapy all patients treated with thiazides.Double-blind, randomized controlled trial.A total 233 hypertensive men aged 35 70 years.Participants were withdrawn prior diuretic treatment replenished oral potassium chloride magnesium oxide. They then 2 months (1)...
BACKGROUND. The use of smokeless tobacco (ST), which has increased in popularity over the past 2 decades, results considerable systemic exposure to nicotine. Nicotine might contribute atherosclerosis by an effect on cardiovascular risk factors. METHODS. effects ST factors and cotinine nicotine levels were studied 1061 professional baseball players during spring training 1988 1989. RESULTS. Of study participants 477 (45%) users. was more common among Whites (55%) than Blacks (29%) or...
AU-rich elements (AREs) are 3' UTR cis-regulatory that regulate the stability of mRNAs. Consensus ARE motifs have been determined, but little is known about how differences in sequences conform to these affect their function. Here, we use functional annotation from UTRs (fast-UTR), a massively parallel reporter assay (MPRA), investigate effects 41,288 sequence fragments 4653 transcripts on gene expression and mRNA Jurkat Beas2B cells. Our analyses demonstrate length an its registration (the...
In this paper estimates are obtained for any scalar function u(x) that staisfies the equationand boundary condition (lb)Here K is a positive constant, Ω an open domain in w-dimensional Euclidean space, v exterior unit normal on Σ, and Tu vector operator
Many studies using reporter assays have demonstrated that 3' untranslated regions (3'-UTRs) regulate gene expression by controlling mRNA stability and translation. Due to intrinsic limitations of heterologous assays, we sought develop a editing approach investigate the regulatory activity 3'-UTRs in their native context. We initially used dual-CRISPR (clustered, regularly interspaced, short palindromic repeats)-Cas9 targeting delete DNA corresponding nine chemokine destabilized assay....
Despite antiretroviral therapy (ART), people with HIV (PWH) on ART experience higher rates of morbidity and mortality vs. age-matched negative controls, which may be driven by chronic inflammation due to persistent virus. We performed bulk RNA sequencing (RNA-seq) peripheral CD4+ T cells, as well quantified plasma immune marker levels from 154 PWH identify host signatures associated recovery (CD4:CD8) persistence (cell-associated DNA RNA). Using a novel dimension reduction tool - Pairwise...
<h3>Objective.</h3> —To examine the extent and correlates of infection with herpes Simplex virus type 1 (HSV-1) 2 (HSV-2) in an inner-city community, we studied prevalence antibodies to these viruses their association risk behaviors a representative sample unmarried white, black, Hispanic adults living San Francisco, Calif. <h3>Design.</h3> —Cross-sectional, community-based, random household survey. <h3>Participants.</h3> —In 1988 1989, surveyed 1770 men women aged 20 44 years from three...
ABSTRACT: To gain information about AIDS knowledge, attitudes, and behavior of junior high school students, 1,967 students in three schools an inner city district were surveyed. Ages the participants ranged from 11–16 years, 48% male. Ethnically, 33% Asian, 31% African‐American, 24% Latino, 5% white. African‐American had greater general knowledge than Asians similar to Latinos whites. Most wanted be taught school. Misconceptions casual contagion common. Students with these misconceptions...
The effects of aging and its correlates on the structure function primary groups in a modern industrial society are examined using theoretical framework suggested by Litwak Szelenyi (1969). After brief summary basic assumptions, series factors discussed that affect group old age unique ways. Alternative theories reviewed. Some measurement issues examined, problems for future research suggested.