A5024351765- HIV Research and Treatment
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- HIV-related health complications and treatments
- Statistical Methods in Clinical Trials
- Reproductive System and Pregnancy
- Algorithms and Data Compression
- Bayesian Methods and Mixture Models
University of California, San Francisco
2023-2025
University of Illinois Urbana-Champaign
2024
University of California System
2024
ABSTRACT Despite antiretroviral therapy (ART), HIV persists in latently-infected cells (“the reservoir”) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people with (PWH) treated during acute infection, we developed a novel mathematical model to predict reservoir peripheral CD4+ T cells. Nonlinear generalized additive models demonstrated rapid biphasic of intact DNA (week 0-5: t 1/2 ∼2.83 weeks; week 5-24: ∼15.4 weeks) that extended out 1 year. These...
Despite antiretroviral therapy (ART), people with HIV (PWH) on ART experience higher rates of morbidity and mortality vs. age-matched negative controls, which may be driven by chronic inflammation due to persistent virus. We performed bulk RNA sequencing (RNA-seq) peripheral CD4+ T cells, as well quantified plasma immune marker levels from 154 PWH identify host signatures associated recovery (CD4:CD8) persistence (cell-associated DNA RNA). Using a novel dimension reduction tool - Pairwise...
Abstract Despite antiretroviral therapy (ART), HIV persists in latently-infected cells (the reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir peripheral CD4 + T cells. Nonlinear generalized additive models demonstrated rapid biphasic of intact DNA (week 0-5: t 1/2 ~ 2.83 weeks; week 5-24: 15.4 weeks) that extended out 1 year. These...
The major barrier to an HIV cure is the reservoir: latently-infected cells that persist despite effective antiretroviral therapy (ART). There have been few cohort-based studies evaluating host genomic or transcriptomic predictors of reservoir. We performed RNA sequencing and reservoir quantification (total DNA [tDNA], unspliced [usRNA], intact DNA) from peripheral CD4+ T 191 ART-suppressed people with (PWH). After adjusting for nadir count, timing ART initiation, genetic ancestry, we...
Biomarkers are often measured in bulk to diagnose patients, monitor patient conditions, and research novel drug pathways. The measurement of these biomarkers suffers from detection limits that result missing untrustworthy measurements. Frequently, imputed so down-stream analysis can be conducted with modern statistical methods cannot normally handle data subject informative censoring. This work develops an empirical Bayes
We describe how we both use and extend the PrarieLearn framework by taking advantage of its built-in support for external auto-graders. By using a custom Docker container, can match our course requirements perfectly. Moreover, relying on flexibility interface customize container. A specific extension unit testing is described which creates context-dependent difference between student answers reference solution providing more comprehensive response at test time.