A5101867811- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Nanoparticles: synthesis and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer Risks and Factors
- Inflammation biomarkers and pathways
- Diet and metabolism studies
- Redox biology and oxidative stress
- Chemotherapy-induced cardiotoxicity and mitigation
- bioluminescence and chemiluminescence research
- Photodynamic Therapy Research Studies
- Diet, Metabolism, and Disease
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
Flinders University
2016-2019
Flinders Medical Centre
2016-2018
Molina Center for Energy and the Environment
2016
Universidade São Judas Tadeu
2008
Injection of lymphotactin (Lptn) into the peritoneum caused an influx lymphocytes at 24 h. Phenotypic analysis cellular showed that a large proportion these cells were T lymphocytes; however, number NK was also present. This effect murine Lptn (mLptn) specific since blocked with mLptn-specific mAb. Similar results observed when injected s.c. and tissue analyzed by immunohistochemistry using anti-CD3epsilon Microchemotaxis assays confirmed respond to mLptn, human clones be similarly...
The objective of the present study was to identify metabolic, cardiovascular and autonomic changes induced by fructose overload administered in drinking water rats for 8 weeks. Female Wistar (200-220 g) were divided into 2 groups: control (N = 8) fructose-fed 5; 100 mg/L weeks). heart rate evaluated pharmacological blockade using atropine (3 mg/kg) propranolol (4 mg/kg). animals submitted an intravenous insulin tolerance test (ITT) blood glucose measurement. a significant increase body...
The combination of doxorubicin and cyclophosphamide commonly used to treat breast cancer can cause premature ovarian failure infertility. α -Tocopherol is a potent antioxidant whereas γ -tocopherol causes apoptosis in variety models vitro including cancer. We hypothesised that the (Dox) 4-hydroperoxycyclophosphamide (4-Cyc) would be more cytotoxic than each agent alone, reduce augment cytotoxicity combined chemotherapeutics. Human MCF-7 KGN cells were exposed Dox, 4-Cyc, Dox -tocopherol, or...
The current study evaluated the potential of gold nanoparticles (AuNPs) for delivery Taxol to breast cancer cells (T47D) using an in vitro cell culture model. For this study, new loading approaches and novel chemical attachments were investigated. Five different nanoparticle-based complexes used determine their cytotoxicity towards T47D 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) viability assay. There was no significant decrease (P > 0.05) when treated with AuNPs...
Background and Objective: Gold nanoparticles (AuNP) conjugated with either EpCAM or TARP antibodies an anticancer agent, paclitaxel (PTX), for tumour targeting therapy were synthesised using a simple chemistry. Methods: The AuNP surface was functionalised two-step modification approach. conjugates characterised Transmission Electron Microscopy (TEM) infrared spectroscopy. Results: cytotoxicity assay of T47D cells treated only to the gold did not show any cells, which indicates these...