A5056951761- Malaria Research and Control
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Complement system in diseases
- vaccines and immunoinformatics approaches
- Invertebrate Immune Response Mechanisms
- Vaccine Coverage and Hesitancy
- Vector-borne infectious diseases
- SARS-CoV-2 and COVID-19 Research
- Reproductive Biology and Fertility
- Parasites and Host Interactions
- Vector-Borne Animal Diseases
- Computational Drug Discovery Methods
- Nitric Oxide and Endothelin Effects
- Dengue and Mosquito Control Research
- Sperm and Testicular Function
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Electrospun Nanofibers in Biomedical Applications
- T-cell and B-cell Immunology
- Global Maternal and Child Health
- Immune Cell Function and Interaction
University of Pennsylvania
2022-2025
VinUniversity
2021-2025
Center for Global Health
2022-2025
The University of Texas at Austin
2021-2025
Charles Darwin University
2021-2024
Busitema University
2024
Pioneer (United States)
2024
Imperial College London
2024
Husson University
2023
Daemen College
2023
Abstract The balance between T helper type 1 (Th1) and 2 (Th2) cells determines the outcome of many important diseases. Using cloned murine cell lines, evidence is provided that Th 1, but not 2, can be activated by specific antigens or a mitogen, concanavalin A, to produce large amounts nitric oxide (NO). Furthermore, NO inhibit secretion interleukin (IL)‐2 interferon‐γ has no effect on IL‐4 production cells. can, thus, distinguished their differential susceptibility NO. exerts...
CD4 + T cells play a major role in protective immunity against the blood stage of malaria, but mechanism protection is unclear. By adoptive transfer cloned cell lines, direct evidence provided that both H 1 and 2 subsets can protect mice Plasmodium chabaudi infection. by nitric oxide-dependent mechanism, whereas enhancement accelerated production specific immunoglobulin G1 antibody.
Schistosomiasis is one of the leading neglected tropical diseases in sub-Saharan Africa. Recorded case numbers this chronic and debilitating helminth disease indicate Nigeria to be most endemic country within region. National control efforts have focused intensively on restricting human contact with freshwater sources intermediate host snails. However, limited attention has been paid role livestock as reservoir hosts prevalence transmission schistosomes humans via farmed animals. The West...
Zika virus, an Aedes mosquito-borne flavivirus, is fast becoming a worldwide public health concern following its suspected association with over 4000 recent cases of microcephaly among newborn infants in Brazil.Prior to emergence Latin America 2015-2016, was known exist at relatively low prevalence parts Africa, Asia and the Pacific islands. An extension apparent global dispersion may be enabled by climate conditions suitable support population growth A. aegypti albopictus mosquitoes...
The effects of weather variables on the transmission vector-borne diseases are complex. Relationships can be non-linear, specific to particular geographic locations, and involve long lag times between predictors outbreaks disease. This study expands geographical temporal range previous studies in Bangladesh mosquito-transmitted viral infection dengue, a major threat human public health tropical subtropical regions worldwide. analysis incorporates new compound such as anomalous events,...
The induction of T-helper cell subsets during the course blood stage Plasmodium chabaudi infection was compared in immunologically intact NIH mice and that were depleted B cells from birth by treatment with anti-mu antibodies. For mice, which acute primary parasitemia peaked 10 days following infection, purified splenic CD4+ T recovered ascending produced high levels vitro interleukin 2 (IL-2) (peak on day 10) gamma interferon (IFN-gamma) 7). Sera collected these at around this time...
Dengue is the most important mosquito-borne viral infection of humans. Although outbreaks disease which are now recognized as clinically consistent with dengue have been reported for centuries, it was not until half a century ago that laboratory identification viruses etiological agent febrile illness achieved. This debilitating and sometimes fatal widely distributed in >125 countries tropical subtropical zones world. Asia, South America Pacific Islands hyper-epidemic regions while currently...
Abstract Aim COVID‐19 rapidly transformed how Australians access health care services. This paper considers the inability for urban patients to in‐person expediated introduction of virtual solutions in service delivery thus creating a new paradigm rural and remote Australians. Context ‘Physical distancing’ is phrase synonymous with public responses Australia, but distance decades‐long problem access. Counterintuitively, pandemic associated restrictions on mobility have reduced real terms...
Abstract Background A global surplus of coronavirus disease 2019 (COVID-19) vaccines exists as a result difficulties in aligning the demand and supply for vaccine manufacturing delivery. World leaders have accelerated development, approval, production distribution pragmatic approach to addressing immediate public health challenges first two half years pandemic. Main body The currently predominant, highly transmissible Omicron variant severe acute respiratory syndrome 2 has brought us closer...
<sec> <title>BACKGROUND</title> Artificial Intelligence (AI) is increasingly being integrated into healthcare, offering a wide array of benefits. Current AI applications encompass patients’ diagnosis, treatment, data mining, and more, to enhance patient care quality life. It also democratizing access expert support by providing timely accurate disease diagnoses, better clinical management, quicker drug discovery, improved prevention, big health protection. </sec> <title>OBJECTIVE</title>...
Small diameter vascular grafts require a complex balance of biomechanical properties to achieve target burst pressure, arterial compliance-matching, and kink resistance prevent failure. Iterative design our multilayer was previously used high compliance while retaining the requisite pressure suture retention strength for clinical use. To impart resistance, custom 3D solution printer add polymeric coil electrospun polyurethane graft support during bending. The addition this reinforcing...
<i>Objective:</i> To use our knowledge of the three-dimensional structure and self-assembly mechanism RNA bacteriophage capsids to develop novel virus-like particles (VLPs) for drug delivery epitope presentation. <i>Methods:</i> Site-directed mutagenesis a recombinant MS2 coat protein expression construct has been used generate translational fusions encompassing short sequences. These chimeric proteins still self-assemble in vivo into <i>T</i> = 3 shells...
OPINION article Front. Public Health, 30 April 2020Sec. Infectious Diseases – Surveillance, Prevention and Treatment Volume 8 - 2020 | https://doi.org/10.3389/fpubh.2020.00174