Free radical polymerization with reversible addition–fragmentation chain transfer (RAFT polymerization) is discussed a view to answering the following questions: (a) How living RAFT polymerization? (b) What controls activity of thiocarbonylthio compounds in (c) do rates differ from those conventional (d) Can agents be used emulsion Retardation, observed when high concentrations certain are and early stages polymerization, how overcome it by appropriate choice reaction conditions, considered...

Radical polymerization with reversible addition−fragmentation chain transfer (RAFT polymerization) can be used to synthesize a wide range of polymers controlled architecture and narrow molecular weight distribution. The polymerizations use agents agents) that possess high coefficients in free radical confer living character on the polymerization. This paper explores effect substituents R dithiobenzoate RAFT [SC(Ph)S−R] outcome styrene, methyl methacrylate (MMA) butyl (BA) or acrylate (MA)....

Free-radical polymerization in the presence of suitable addition−fragmentation chain transfer agents [SC(Z)S−R] (RAFT agents) possess characteristics a living (i.e., polymer products can be reactivated for extension and/or block synthesis, molecular weights are predetermined by RAFT agent concentration and conversion, narrow polydispersities possible). Styrene polymerizations (110 °C, thermal initiation) were performed two series [SC(Z)S−CH2Ph SC(Z)S−C(Me)2CN]. The coefficients decrease...

Stable polydopamine capsules are prepared by the single-step deposition and self-polymerization of dopamine onto a range colloidal silica template particles with different sizes porosities. MTT assays reveal negligible cytotoxicity toward cells.

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTLiving Polymers by Use of Trithiocarbonates as Reversible Addition−Fragmentation Chain Transfer (RAFT) Agents: ABA Triblock Copolymers Radical Polymerization in Two StepsRoshan T. A. Mayadunne, Ezio Rizzardo, John Chiefari, Julia Krstina, Graeme Moad, Almar Postma, and San H. ThangView Author Information CSIRO Molecular Science, Bag 10, Clayton South, Victoria 3169, Australia Cite this: Macromolecules 2000,...

We report a facile approach to immobilize pH-cleavable polymer-drug conjugates in mussel-inspired polydopamine (PDA) capsules for intracellular drug delivery. Our design takes advantage of the PDA coating form capsules, chemical reactivity films, and acid-labile groups polymer side chains sustained pH-induced release. The anticancer doxorubicin (Dox) was conjugated thiolated poly(methacrylic acid) (PMASH) with hydrazone bond, then immobilized via robust thiol-catechol reactions between...

Abstract The preparation of monodisperse polymer (polydopamine, PDA) capsules by a one‐step interfacial polymerization dopamine onto dimethyldiethoxysilane (DMDES) emulsion droplets and removal the DMDES templates with ethanol is reported. diameters PDA can be tailored from 400 nm to 2.4 µm varying either condensation time or concentration used for templating. Further, defined nanometer‐scale shell thicknesses (ranging ∼10 30 nm) prepared adjusting concentration. This thickness increased...

Fully loaded: Noncovalent anchoring of liposomes into polymer multilayered films with cholesterol-modified polymers allows the preparation capsosomes-liposome-compartmentalized capsules (see picture). A quantitative enzymatic reaction confirmed presence active cargo within capsosomes and was used to determine number subcompartments this novel biomedical carrier system.

Phthalimidomethyl trithiocarbonate reversible addition−fragmentation chain transfer (RAFT) agents are effective in imparting living characteristics to radical polymerizations of butyl acrylate (BA) and N-isopropylacrylamide (NIPAM) provide a route end-functional polymers with predictable molecular weight narrow distributions (e.g., number-average for PBA (M̄n) = 21 300 polydispersity (M̄w/M̄n) 1.1 at 96% conversion). End group determination suggests that bimodal long branches arise by...

We report a general click chemistry approach for the layer-by-layer assembly of ultrathin, polymer films on particles and subsequent formation capsules (CCs). Poly(acrylic acid) copolymers, synthesized with minor component either alkyne (PAA-Alk) or azide (PAA-Az) functionality, were alternately assembled silica particles. The (PAA-Az/PAA-Alk)-coated subsequently functionalized by exploiting free moieties present in film upon exposure to an azide-modified rhodamine dye. Further, PAA CCs,...

Phthalimidomethyl trithiocarbonates are used as reversible addition fragmentation chain transfer (RAFT) agents to provide low polydispersity α-(phthalimidomethyl)polystyrene with number-average molecular weight in the range 1000−100000 g mol-1. The activity of phthalimidomethyl RAFT polymerization styrene, which appears be similar that analogous benzyl trithiocarbonates, is attributed electrophilic character group. trithiocarbonate functionality products was quantitatively transformed inert...

This review focuses on the approaches to synthesis of functional polymers for optoelectronic applications that make use radical polymerization with reversible addition–fragmentation chain transfer (RAFT) polymerization. Optoelectronic include hole/electron transport in photovoltaics (OPVs), light emitting diodes (OLEDs and PLEDs), thin-film transistors (TFTs), sensors, light-harvesting related applications. In this context we consider metallopolymers (polymers incorporate a metal or possess...

PGA-dopamine conjugates (PGAPDA) were synthesized and assembled onto silica particles to yield biodegradable capsules with tunable degradation properties. Increasing the dopamine content results in thicker films a concomitant reduction kinetics. These tailored are expected find application diverse areas, including drug gene delivery.

This study describes a facile and high yielding route to two series of polymethacrylates inspired by the naturally occurring, tryptophan-rich cationic antimicrobial polymers. Appropriate optimization indole content within each gave rise polymers with potency against Staphylococcus epidermidis (e.g., PGI-3 minimum inhibitory concentration (MIC) = 12 μg/mL) methicillin-resistant strain aureus MIC 47 minimal toxicity toward human red blood cells. Future work will be directed understanding...

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTThermolysis of RAFT-Synthesized Polymers. A Convenient Method for Trithiocarbonate Group EliminationAlmar Postma, Thomas P. Davis, Graeme Moad, and Michael S. O'SheaView Author Information CSIRO Molecular Science, Bayview Ave, Clayton, 3168, Vic, Australia, Centre Advanced Macromolecular Design, School Chemical Engineering Industrial Chemistry, The University New South Wales, Sydney, 2052, NSW, Australia Cite...

Exploiting microfluidic principles, the potential for chip-based multilayer assembly synthesis of polymer microcapsules was investigated. We demonstrate that continuous flow is a fast, efficient, automated alternative to conventional batch synthesis. In this work, we dispersed liquid crystal (LC) molecules (organic phase) as monodisperse droplets in an aqueous phase containing primary and suitable surfactant. The coadsorbed with surfactant at organic/aqueous interface, stabilizing LC against...

We report the synthesis and characterization of DNA-grafted poly(N-isopropylacrylamide) (PNIPAM) micelles, their assembly into multilayered thin films, subsequent generation poly(ethylene glycol) (PEG) functionalization DNA−PNIPAM microcapsules. Multilayer films were assembled by sequentially depositing PNIPAM micelles containing cDNA sequences polyA30 or polyT30 (i.e., PNIPAM-A30 PNIPAM-T30). DNA−polymer microcapsules obtained alternate deposition PNIPAM-T30 onto silica particles, followed...

The photolithographical patterning of hydrogels based solely on the surface immobilization and cross-linking alkyne-functionalized poly(ethylene glycol) (PEG-tetraalkyne) is described. Photogenerated radicals as well UV absorption by a copper chelating ligand result in photochemical redox reduction Cu(II) to Cu(I). This catalyzes alkyne–azide click reaction graft onto an azide-functionalized plasma polymer (N3PP) film. photogenerated were also able abstract hydrogen atoms from...

Capsosomes, that is, polymer capsules containing liposomal subcompartments, represent a promising new concept towards the design of artificial cells. Herein, capsosomes with control over position subunits, "free-floating" in capsule interior and/or associated membrane, are reported. The functionality these is demonstrated via temperature-triggered encapsulated catalysis using subtilisin. Detailed facts importance to specialist readers published as "Supporting Information". Such documents...

We present a generic and versatile method for functionalization of disulfide-stabilized PMA hydrogel capsules (HCs) with macromolecules, including number specific antibodies to cancer cells. Functionalization was achieved by reversible addition–fragmentation chain transfer (RAFT) polymerization poly(N-vinyl pyrrolidone) (PVPON), which introduced biorelevant heterotelechelic end groups (thiol amine) the polymer chain. The PVPON conjugated outermost layer HCs through thiol reacted biotin via...