Summary This guideline advises on the management of patients with cow's milk allergy. Cow's allergy presents in first year life estimated population prevalence between 2% and 3%. The clinical manifestations are very variable type severity making it most difficult food to diagnose. A careful age‐ disease‐specific history relevant tests including detection milk‐specific I g E (by skin prick test or serum assay), diagnostic elimination diet, oral challenge will aid diagnosis cases. Treatment is...

Summary Peanut nut and tree allergy are characterised by IgE mediated reactions to proteins. Nut is a global disease. Limited epidemiological data suggest varying prevalence in different geographical areas. Primary affects over 2% of children 0.5% adults the UK. Infants with severe eczema and/or egg have higher risk peanut allergy. presents most commonly first five years life, often after known ingestion typical rapid onset IgE‐mediated symptoms. The clinical diagnosis primary can be made...

Pollen food syndrome (PFS) is a highly prevalent allergy affecting pollen-sensitized children and adults. Sufferers experience allergic symptoms when consuming raw plant foods, due to the homology between pollen allergens unstable proteins in these foods. The triggers involved can vary depending on sensitization, which turn affected by geographical location. British Society of Allergy Clinical Immunology (BSACI) Standards Care Committee (SOCC) identified need develop guideline for diagnosis...

OBJECTIVE--To determine the cumulative prevalences of wheeze and doctor diagnosed asthma point recurrent cough in children aged 5 years under. DESIGN--Questionnaire survey population based random sample registered on regional authority9s child health index for immunisation; questionnaire completed by parents. SETTING--Leicestershire. SUBJECTS--1650 white born 1985-9 who were surveyed 1990. MAIN OUTCOME MEASURES--Cumulative age sex. RESULTS--There 1422 replies (86.2%; 726 boys, 696 girls)....

We studied the natural history of preschool respiratory symptoms in a population-based sample children followed during early school years. Current symptoms, ventilatory function, bronchial responsiveness to methacholine (BR), atopic status, and peak expiratory flow variability (PEFV) were assessed. Among those initially asymptomatic (210 subjects), 83.3% remained symptom-free, 6.7% started wheeze, 10% developed recurrent cough. Nearly half (46.9%) initial wheezing group (145 subjects) became...

Summary This guidance for the prescription of an adrenaline auto‐injector has been prepared by Standards Care Committee ( SOCC ) British Society Allergy and Clinical Immunology BSACI ). There is insufficient quality evidence‐based data in some areas, including question how often a second dose required, optimal absorption after subcutaneous vs. intramuscular injection. Thus, indications (which are partly opinion based) guidelines from different countries vary slightly. The guideline based on...

Objectives: The aim of this study was to explore, using qualitative methods, the experiences children and their parents living with nut allergy. Methods: Children a confirmed diagnosis peanut allergy were identified from database patients maintained at an clinic large teaching hospital. Interviews 26 families conducted involving 11 children, 25 mothers 12 fathers. Results: signalled critical transition—or biographical disruption—in life family. Parents took on role ‘alert assistant’ sought...

The development of tolerance to cow's milk in allergic children is best determined by supervised baked exposure. Widely recommended hospital-based challenges can potentially delay contact because resource limitations.We sought determine the efficacy and safety our low-dose home-based reintroduction programme.In allergy service, with IgE-mediated who met set criteria (presenting skin and/or gastrointestinal symptoms only prick test < 8 mm) are considered for (HMR). Early ingestion a...

We aimed to assess the pharmacokinetics of vancomycin in critically ill infants, and evaluate standard recommended dose 10 mg/kg 6 hourly. All infants admitted Baragwanath Hospital ICU who had arterial lines situ, for whom hourly was prescribed an infective insult parental consent, were included study. Vancomycin infused over 60 minutes. Serum samples taken immediately before at 30, 60, 120 300 minutes after end infusion, on days 2 8 therapy. Extrapolated peak concentration (Cmax), trough...

Objective The use of the Pediatric Risk Mortality (PRISM) score or other scoring systems in intensive care unit (ICU) is great importance for evaluating efficacy and efficiency a particular ICU. However, PRISM was developed validated United States subsequently Europe, but has not been evaluated less affluent society. In general, should be used only populations similar to reference population which prediction model developed. We set out determine applicability at Baragwanath Hospital, South...

To cite this article : Ball H, Luyt D, Bravin K, Kirk K. Single nut or total avoidance in allergic children: outcome of challenges to guide exclusion diets. Pediatr Allergy Immunol 2011: 22 808–812. Abstract Background: Children with diagnosed allergy are typically advised by health professionals exclude all nuts from their diets, irrespective the testing, avoid inadvertent contact through contamination possible development new allergies. Methods: In our service, as we feel greater...

We investigated the outcome for a sample of children in whom recurrent cough was reported preschool years to determine 1) whether they shared characteristics attributed variant asthma, and 2) proportion who developed classical wheezy asthma at follow-up during early school years. A cohort identified as having period reassessed Previously asymptomatic remained symptom-free provided comparison group with respect current respiratory symptoms, lung function, bronchial reactivity inhaled...

OBJECTIVE--To describe the characteristics of wheeze and its relation with doctor diagnosed asthma in children aged 5 years under. DESIGN--Questionnaire survey population based random sample registered on Leicestershire Health Authority9s child health index for immunisation; questionnaire completed by parents. SUBJECTS--1650 white born 1985 to 1989 who were surveyed 1990. MAIN OUTCOME MEASURES--Age distribution, severity, precipitants, seasonal characteristics, diurnal variation wheeze,...

Nocturnal cough in asthma is a common but poorly understood phenomenon. The aims of this study were to determine the relationship between recorded night cough, reported and current wheeze population-based sample children previously identified as wheezy, examine nocturnal symptoms, markers severity environmental exposure. Children reassessed early school years by measuring ventilatory function, bronchial reactivity, peak flow variability, respiratory symptom diaries home monitoring overnight...

Although the natural history of cow's milk allergy is to resolve during childhood or adolescence, a small but significant proportion children will remain allergic. Specific oral tolerance induction (CM-SOTI) provides treatment option in these with continuing high success rates. However current sentiment limits widespread availability as existing reports advise that it too soon translate CM-SOTI into routine clinical practice.In January 2007 we implemented slow up-dosing program. Eligible...

Summary Background Specific immunotherapy (SIT) is an effective treatment for grass and/or tree pollen‐induced severe allergic rhinoconjunctivitis. However, there are limited detailed data on the use of in children United Kingdom. Objectives We audited NHS paediatric practice against current national guidelines to evaluate patient selection, SIT modalities and adverse events (AEs). Methods Paediatricians offering pollen were identified through British Society Allergy Clinical Immunology...

Pulmonary function tests were performed in 15 thalassemic patients (age 5 years 8 months to 18 6 months), receiving both regular transfusions and desferrioxamine, determine the presence nature of any abnormalities lung function. Reactive oxidant production from neutrophils was measured simultaneously ascertain if a causal relationship existed between free radical tissue damage lungs. Mean total capacity, mean residual volume, forced vital capacity significantly reduced, indicating...

The management of cow's milk allergy (CMA) includes initial dairy exclusion with suitable dietary substitution, diagnostic challenges where indicated, and supervised re-introduction as the condition resolves. Information on clinician practice is limited. We audited current clinicians in UK to evaluate adherence international guidelines.An online questionnaire was sent all whose included children identified national society website. One hundred sixty questionnaires were 116 (73%)...