A5040159239- Characterization and Applications of Magnetic Nanoparticles
- Geomagnetism and Paleomagnetism Studies
- Microfluidic and Bio-sensing Technologies
- Magnetic properties of thin films
- Electrical and Bioimpedance Tomography
- Nanoparticle-Based Drug Delivery
- Economic and Financial Impacts of Cancer
- Minerals Flotation and Separation Techniques
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Liver Disease Diagnosis and Treatment
- Electromagnetic Compatibility and Noise Suppression
- Gene expression and cancer classification
- Infrared Thermography in Medicine
- Cancer Cells and Metastasis
- Organ Transplantation Techniques and Outcomes
- Advanced Battery Technologies Research
- AI in cancer detection
- Gastroesophageal reflux and treatments
- Effects of Radiation Exposure
- Phytoplasmas and Hemiptera pathogens
- Aerospace Engineering and Control Systems
- Systemic Sclerosis and Related Diseases
- Nanomaterials for catalytic reactions
- Colorectal Cancer Treatments and Studies
University of California, Berkeley
2013-2024
National University of Singapore
2021
Hearst (United States)
2016-2021
Huntington Hospital
2021
Harvard University Press
2019
Graduate Theological Union
2018
Ford Motor Company (United States)
2018
Rutgers, The State University of New Jersey
2011-2012
Image-guided treatment of cancer enables physicians to localize and treat tumors with great precision. Here, we present in vivo results showing that an emerging imaging modality, magnetic particle (MPI), can be combined hyperthermia into image-guided theranostic platform. MPI is a noninvasive 3D tomographic method high sensitivity contrast, zero ionizing radiation, linearly quantitative at any depth no view limitations. The same superparamagnetic iron oxide nanoparticle (SPIONs) tracers...
Cancer remains one of the leading causes death worldwide. Biomedical imaging plays a crucial role in all phases cancer management. Physicians often need to choose ideal diagnostic modality for each clinical presentation based on complex trade-offs among spatial resolution, sensitivity, contrast, access, cost, and safety. Magnetic particle (MPI) is an emerging tracer that detects superparamagnetic iron oxide (SPIO) nanoparticle with high image contrast (zero tissue background signal),...
Stem cell therapies have enormous potential for treating many debilitating diseases, including heart failure, stroke and traumatic brain injury. For maximal efficacy, these require targeted delivery to specific tissues followed by successful engraftment. However, remains an open challenge. As one example, it is common intravenous deliveries of mesenchymal stem cells (MSCs) become entrapped in lung microvasculature instead the target tissue. Hence, a robust, quantitative imaging method would...
Gastrointestinal (GI) bleeding causes more than 300 000 hospitalizations per year in the United States. Imaging plays a crucial role accurately locating source of bleed for timely intervention. Magnetic particle imaging (MPI) is an emerging clinically translatable modality that images superparamagnetic iron-oxide (SPIO) tracers with extraordinary contrast and sensitivity. This linearly quantitative has zero background tissue signal depth attenuation. MPI also safe: there ionizing radiation...
Pulmonary embolism (PE), along with the closely related condition of deep vein thrombosis, affect an estimated 600 000 patients in US per year. Untreated, PE carries a mortality rate 30%. Because many experience mild or non-specific symptoms, imaging studies are necessary for definitive diagnosis PE. Iodinated CT pulmonary angiography is recommended most patients, while nuclear medicine-based ventilation/perfusion (V/Q) scans reserved whom use iodine contraindicated. Magnetic particle (MPI)...
Pulmonary delivery of therapeutics is attractive due to rapid absorption and non-invasiveness but it challenging monitor quantify the delivered aerosol or powder. Currently, single-photon emission computed tomography (SPECT) used requires inhalation radioactive labels that typically have be synthesized attached by hot chemistry techniques just prior every scan. Methods: In this work, we demonstrate superparamagnetic iron oxide nanoparticles (SPIONs) can label track aerosols in vivo with high...
Magnetic particle imaging (MPI) is an emerging tracer-based medical modality that images non-radioactive, kidney-safe superparamagnetic iron oxide (SPIO) tracers. MPI offers quantitative, high-contrast and high-SNR images, so has exceptional promise for applications such as cell tracking, angiography, brain perfusion, cancer detection, traumatic injury pulmonary imaging. In assessing MPI's utility mentioned above, it important to be able assess tracer short-term biodistribution well...
Islet transplantation (Tx) represents the most promising therapy to restore normoglycemia in type 1 diabetes (T1D) patients date. As significant islet loss has been observed after procedure, there is an urgent need for developing strategies monitoring transplanted grafts. In this report we describe first time application of magnetic particle imaging (MPI) islets liver and under kidney capsule experimental animals.Pancreatic isolated from Papio hamadryas were labeled with superparamagnetic...
An important criterion for identifying complicated objects with multiple attributes is the use of domain knowledge which reflects precise spatial linking constituent attributes. Hence, simply detecting presence low-level that constitute object, even in cases where these might be detected proximity to each other usually not a robust strategy. The O'Callaghan neighborhood an ideal vehicle characterizing comprised spatially connected fashion because it allows modeling and imposing distance...
White blood cells (WBCs) are a key component of the mammalian immune system and play an essential role in surveillance, defense, adaptation against foreign pathogens. Apart from their roles active combat infection development adaptive immunity, also involved tumor metastasis. Antibody-based therapeutics have been developed to regulate (i.e. selectively activate or inhibit function) harness fight malignancy. Alternatively, non-invasive tracking WBC distribution can diagnose inflammation,...
This paper investigates thermal ablation of cancer tissue as a controls problem. The objective is to deliver lethal dose energy the without damaging critical nearby healthy tissue. proposes model predictive controller (MPC) regulate dose. guarantees safety surrounding tumor. cost function rewards killing cells. Simulations comparing proposed with bang-bang used in practice demonstrate that MPC kills more and requires less time than controller, while
Covers advancements in spacecraft and tactical strategic missile systems, including subsystem design application, mission analysis, materials structures, developments space sciences, processing manufacturing, operations, applications of technologies to other fields.
Magnetic particle imaging (MPI) is a noninvasive method that detects superparamagnetic iron oxide (SPIO) nanoparticles within the body by their nonlinear behavior in presence of external magnetic selection field. This study characterized small-scale MPI magnet. The researchers have been able to shift Field Free Line (FFL)through field view altering currents two coils as predicted simulations. Preliminary measurements indicate iron-returned FFL magnet promising design approach for future...
417 Background: Trial results from ML18147 and VELOUR have recently reported outcomes for BV+CT AFLI+CT in mCRC patients previously treated with BEV. This study evaluates cost of vs as 2L treatment who progressed after receiving a standard BEV containing regimen the 1L setting. Methods: In absence head-to-head trials comparing & AFLI+CT, an adjusted indirect comparison was conducted using Bucher-method. Hazard ratios (HRs) CT BV were utilized. An illness-death Markov model enhanced...
MPI shows great promise for safe angiography, blood pool, and perfusion imaging. images have unprecedented contrast that enables unambiguous measurements of tracer quantity location [1-4]. At present, pre-clinical resolution does not compare with MRI CT, which routinely achieve better than 100-micron resolution. MPI's low is primarily due to limitations in hardware magnetic nanoparticles. To begin close this gap, we are developing higher-field gradients [3] specialized nanoparticles [4]....
As shown in Fig. 1b, the mean magneto stimulation thresholds for transverse field was approximately 3 times lower than axial (ΔB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">min</sub> = 26 mT-pp vs. 78 mT-pp) same set of subjects, with comparable τc values (265 μs 243 μs). In addition, percentage deviation across subjects significantly smaller (13%) (28%). For both and fields, data trends were well modeled by hyperbolic amplitude frequency...