A5039609225- Characterization and Applications of Magnetic Nanoparticles
- Geomagnetism and Paleomagnetism Studies
- Microfluidic and Bio-sensing Technologies
- Magnetic properties of thin films
- Nanoparticle-Based Drug Delivery
- Ferroelectric and Piezoelectric Materials
- Iron oxide chemistry and applications
- Nanocluster Synthesis and Applications
- Nanomaterials for catalytic reactions
- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Dielectric materials and actuators
- Antimicrobial Peptides and Activities
- Conducting polymers and applications
- NMR spectroscopy and applications
- Escherichia coli research studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrical and Thermal Properties of Materials
- Semiconductor materials and devices
- Electrical and Bioimpedance Tomography
- Angiogenesis and VEGF in Cancer
- Power Transformer Diagnostics and Insulation
- Magnetic Properties and Synthesis of Ferrites
- Cystic Fibrosis Research Advances
- Coronary Interventions and Diagnostics
University of California, Berkeley
2019-2023
Hearst (United States)
2021
Huntington Hospital
2021
Clemson University
2015-2018
Sandia National Laboratories
2009-2015
Materials Science & Engineering
2015
Office of Scientific and Technical Information
2009
National Technical Information Service
2009
Energy Fuels (United States)
2008
Energy Transitions (United Kingdom)
2008
The synthesis of well-defined nanoparticle materials has been an area intense investigation, but size control in syntheses is largely empirical. Here, we introduce a general method for fine the nanoparticles by establishing steady state growth conditions through continuous, controlled addition precursor, leading to uniform rate particle growth. This approach, which term "extended LaMer mechanism" allows reproducibility from batch as well ability predict monitoring early stages We have...
The use of magnetic nanoparticles in biomedical applications provides are a wealth opportunities. Nonetheless, to truly understand the interactions these materials biological media, detailed characterization is necessary with complex systems. This Feature highlights some "best practices" analytical techniques and challenges measurement properties materials.
Abstract Magnetic nanoparticles have many advantages in medicine such as their use non‐invasive imaging a Particle Imaging (MPI) tracer or Resonance contrast agent, the ability to be externally shifted actuated and excited generate heat release drugs for therapy. Existing gentle sigmoidal magnetization response that limits resolution sensitivity. Here it is shown superferromagnetic iron oxide nanoparticle chains (SFMIOs) achieve an ideal step‐like improve both image & SNR by more than...
Magnetic particle imaging (MPI) is a sensitive, high-contrast tracer modality that images superparamagnetic iron oxide nanoparticles, enabling radiation-free theranostic imaging. MPI resolution currently limited by scanner and constraints. Recent tracers have experimentally shown 10× signal improvements with dramatically sharper M–H curves. Experiments show dependence on interparticle interactions, conforming to literature definitions of superferromagnetism. We thus call our...
White blood cells (WBCs) are a key component of the mammalian immune system and play an essential role in surveillance, defense, adaptation against foreign pathogens. Apart from their roles active combat infection development adaptive immunity, also involved tumor metastasis. Antibody-based therapeutics have been developed to regulate (i.e. selectively activate or inhibit function) harness fight malignancy. Alternatively, non-invasive tracking WBC distribution can diagnose inflammation,...
Magnetic particle imaging (MPI) is a new tracer-based modality that useful in diagnosing various pathophysiology related to the vascular system and for sensitive tracking of cytotherapies. MPI uses nonradioactive easily assimilated nanometer-sized iron oxide particles as tracers. images nonlinear Langevin behavior has allowed detection oxide-labeled therapeutic cells body. This review will provide an overview technology, tracer, its use cytotherapies using molecular targets.
New technologies that do not rely on antibiotics are urgently needed to treat bacterial infections caused by multidrug‐resistant bacteria. Herein, the feasibility of using alternating magnetic field (AMF) selectively kill enterotoxigenic Escherichia coli strain K99 ( EC K99) in presence multianchored glycoconjugate‐functionalized nanoparticles is explored. Poly(ethylene oxide)‐poly(acrylic acid)‐dopamine functionalized (PEO‐MNPs) synthesized and with bacteria‐specific glycoconjugate...
Thiolated poly(acrylic acid) (PAA-SH) functionalized gold nanoparticles were explored as a colloidal catalyst with potential application recoverable where the PAA provides pH-responsive dispersibility and phase transfer capability between aqueous organic media. This system demonstrates complete nanoparticle recovery redispersion over multiple reaction cycles without changes in morphology or reduction conversion. The catalytic activity (rate constant) was reduced subsequent reactions when by...
Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs Enterotoxigenic Escherichia coli (ETEC) strain K99 (EC K99) is investigated different microscopic techniques. Our results suggest that can effectively act as non-antibiotic anti-adhesion agents for treating ETEC infections.
Nonstoichiometric cobalt ferrite nanoparticles have drawn interest in magnetically mediated energy delivery due to their high magnetocrystalline anisotropy and peak loss frequency. The use of an extended LaMer synthesis allows for size control the doped particles up a threshold core diameter 18 nm. Above this diameter, become unstable drop out suspension, allowing further nucleation events occur. This leads cyclic nucleation, growth, destabilization regime seen during course reaction. Using...
Superferromagnetic iron oxide (SFMIOs) is a new paradigm for Magnetic Particle Imaging (MPI) as it approaches the ideal imaging agent characteristics of steep, step-like magnetization curve. Other than expected 10-fold SNR and spatial resolution improvements from square-like hysteresis curve, we demonstrate other unique qualities SFMIOs that enable robust "chemical-shift-like" color multiplexing to potentially range magnetic "dyes" work at-depth imaging. We also extremely high sensitivity...
Magnetic Particle Imaging (MPI) is a tracer-based imaging modality with immense promise as radiation-free alternative to nuclear medicine techniques. Nuclear requires "hot chemistry" wherein radioactive tracers must be synthesized on-site, requiring expensive infrastructure and labor costs. MPI's magnetic nanoparticles, superparamagnetic iron oxide nanoparticles (SPIOs), have no significant signal decay over time which removes cost barriers associated studies such FDG-PET. While SPIOs are...
Abstract Magnetic Particle Imaging (MPI) is a noninvasive imaging modality that exploits the saturation properties of superparamagnetic iron oxide particles (SPIOs). A major thrust MPI research aims to sharpen magnetic resolution biocompatible SPIOs, which will be crucial for affordable and safe clinical translation. We recently reported on new class tracers —called superferromagnetic nanoparticles (SFMIOs) — offer much sharper curves. SFMIOs experimentally demonstrate 10-fold improvement in...
Abstract Introduction Clinical adoption of NK cell immunotherapy is underway for medulloblastoma and osteosarcoma, however there currently little feedback on fate after administration. We propose magnetic particle imaging (MPI) the detection, localization, quantification VivoTrax-labeled cells. Methods Human-derived NK-92 cells were labeled by co-incubation with VivoTrax 24 hours then excess nanoparticles washed centrifugation. Cytolytic activity vs. unlabeled was assessed 4 co- incubation...
Superparamagnetic iron oxide nanoparticles (SPIOs) are used as tracers in Magnetic Particle Imaging (MPI). It is crucial to understand the magnetic properties of SPIOs for optimizing MPI imaging contrast, resolution, and sensitivity. Brownian Néel relaxation theory developed early 1950s posits that times can vary with particle size, shell thickness, medium viscosity, applied field strength. soon provide a unique capability, ability distinguish bound from unbound vivo. Yet experimental...
Molecular imaging tools can noninvasively track cells in vivo. However, no techniques today rapidly monitor cell therapies to allow for nimble treatment optimization each patient, the epitome of Personalized Medicine. Magnetic Particle Imaging (MPI) is a new tracer technology that could soon provide MDs unequivocal therapy feedback just three days. MPI with Brownian SPIOs shows promise towards noninvasive sensing viability via viscosity changes apoptotic cells. This unique ability greatly...
Abstract Background Sentinel lymph node biopsy (SLNB) is an important cancer diagnostic staging procedure. Conventional SLNB procedures with 99mTc radiotracers and scintigraphy are constrained by tracer half-life and, in some cases, insufficient image resolution. Here, we explore alternative magnetic (nonradioactive) image-guided Purpose To demonstrate that particle imaging (MPI) lymphography can sensitively, specifically, quantitatively identify map sentinel modes (SLNs) murine models...