A5003585902- Ovarian function and disorders
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Assisted Reproductive Technology and Twin Pregnancy
- Estrogen and related hormone effects
- Endometriosis Research and Treatment
- Menopause: Health Impacts and Treatments
- Reproductive Health and Technologies
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Gynecological conditions and treatments
- Prenatal Screening and Diagnostics
- Sexual Differentiation and Disorders
- Hormonal and reproductive studies
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Neuroendocrine regulation and behavior
- Preterm Birth and Chorioamnionitis
- Infant Development and Preterm Care
- Reproductive Physiology in Livestock
- Effects and risks of endocrine disrupting chemicals
Ferring Pharmaceuticals (Denmark)
2010-2021
Asociación Colombiana de Facultades de Ingeniería
2020
Ferring Pharmaceuticals (United States)
2018-2019
Ferring Pharmaceuticals (Switzerland)
2003-2015
Joint Research Center
2012
Hôpital Saint Eloi
2011
Ghent University
2011
Ghent University Hospital
2011
Sahlgrenska University Hospital
2005-2011
Rigshospitalet
2005-2011
LH activity may influence treatment response and outcome in IVF cycles.A randomized, assessor-blind, multinational trial compared ongoing pregnancy rates (primary end-point) 731 women undergoing after stimulation with highly purified menotrophin (HP-hMG) (n = 363) or recombinant FSH (rFSH) 368) following a long GnRH agonist protocol. Patients received identical pre- post-randomization interventions. One two embryos were transferred on day 3.More oocytes retrieved (P < 0.001) rFSH (11.8)...
Highly purified menotrophin (HP-hMG) has been associated with fewer oocytes retrieved and a higher proportion of top-quality embryos compared recombinant FSH (rFSH).A randomized, assessor-blind, multinational trial in 731 women undergoing IVF after stimulation HP-hMG (MENOPUR) (n = 363) or rFSH (GONAL-F) 368) following long GnRH agonist protocol was conducted. Blood collected before, during stimulation. Fluid from follicles > =17 mm.Serum androstenedione, total testosterone free androgen...
ObjectiveTo evaluate the dose–response relationship of a novel recombinant human FSH (rhFSH; FE 999049) with respect to ovarian response in patients undergoing IVF/intracytoplasmic sperm injection treatment; and prospectively study influence initial antimüllerian hormone (AMH) concentrations.DesignRandomized, controlled, assessor-blinded, AMH-stratified (low: 5.0–14.9 pmol/L [0.7–<2.1 ng/mL]; high: 15.0–44.9 [2.1–6.3 ng/mL]) trial.SettingSeven infertility centers four countries.Patient(s)Two...
ObjectiveTo compare antimüllerian hormone (AMH) and antral follicle count (AFC) as predictors of ovarian response to controlled stimulation at individual fertility clinics.DesignRetrospective analysis study center data in two multicenter trials. Centers that provided >10 patients were included the analysis.SettingA total 19 (n = 519 patients) 18 centers 686 participating a long GnRH agonist trial (MERIT) antagonist (MEGASET), respectively.Patient(s)Infertile women good...
Eleven high mileage runners (HR) (108.0 +/- 4.5 km.wk-1), 9 moderate (MR) (54.2 3.7 km.wk-1) and 10 sedentary controls (SC) of similar age (28.3 1.5 yr) were studied to evaluate the effects volume endurance training on reproductive function in male runners. Levels reproductive, adrenal thyroid hormones measured during a 1-hr period serial blood sampling (q20 min) urinary excretion 24-hr luteinizing hormone (uLH) was determined two separate days. Semen exams sperm penetration standard...
BACKGROUNDThis study evaluated the predictive value of serum and follicular fluid (FF) concentrations anti-Müllerian hormone (AMH) with respect to treatment outcome variables in an IVF cycle.
Abstract Male factor infertility is increasing and recognized as playing a key role in reproductive health disease. The current primary diagnostic approach to assess sperm quality associated with reduced number motility, which has been historically of limited success separating fertile from infertile males. study was designed develop molecular analysis identify male idiopathic using genome wide alterations DNA methylation. A signature differential methylation regions (DMRs) identified be...
This study aimed to establish the efficacy and safety of ovarian stimulation with a follitropin delta individualized fixed-dose regimen based on serum anti-Müllerian hormone (AMH) concentration body weight versus conventional beta dosing in Japanese women.This randomized, controlled, assessor-blind, multicentre, non-inferiority trial was conducted 347 IVF/intracytoplasmic sperm injection patients. They were randomized (AMH <15 pmol/l: 12 µg/day; AMH ≥15 0.10-0.19 µg/kg/day; minimum 6 maximum...
Is ovarian stimulation with follitropin delta in its individualised fixed-dose regimen at least as efficacious alfa a conventional dosing Asian population?Ovarian resulted non-inferior ongoing pregnancy rate, significantly higher live birth rate and lower incidence of early hyperstimulation syndrome (OHSS) and/or preventive interventions compared to dosing.Previous randomised controlled trials conducted Japan well Europe, North- South America have demonstrated that the based on serum...
BACKGROUND: The contribution of the LH activity in menotrophin preparations for ovulation induction has been investigated small trials conducted versus FSH preparations. objective this study was to demonstrate non-inferiority highly purified urinary (HP-HMG) recombinant (rFSH) with respect primary outcome measure, rate. METHODS: This a randomized, open-label, assessor-blind, multinational study. Women anovulatory infertility WHO Group II and resistant clomiphene citrate were randomized...
BACKGROUND: The objective of this investigation was to determine the inter- and intraobserver agreement when assessing embryo quality. METHODS: This included 4002 cleaved embryos from 7535 oocytes retrieved in 688 patients undergoing IVF cycles a multicentre trial. Embryos were evaluated locally at inverted microscope 28, 44 68 h (±1 h) post-insemination. Digital images assessed centrally by three blinded embryologists. To assess reproducibility, 215 randomly selected 33 re-evaluated central...
Ovarian hyperstimulation syndrome (OHSS) seems to be induced by the ovarian release of vascular endothelial growth factor (VEGF), which increases permeability. Dopamine agonists inhibit VEGF receptor phosphorylation and thereby decrease permeability.A randomized, double-blind, placebo-controlled, multicentre study assessing three oral doses (50, 100, 200 microg/day) non-ergot derived dopamine agonist quinagolide started on day human chorionic gonadotrophin (hCG) continued for 17-21 days...
Is individualization of dosing with follitropin delta in sequential ovarian stimulation cycles an effective preventive strategy for hyperstimulation syndrome risk? If so, which patients does individualized provide the greatest OHSS risk reduction and/or need additional interventions?A secondary analysis three IVF/intracytoplasmic sperm injection included one randomized, assessor-blinded trial comparing two recombinant FSH preparations (ESTHER-1, NCT01956110), and a second women undergoing up...
To evaluate the immunogenicity of follitropin delta in repeated ovarian stimulation.Controlled, assessor-blind trial IVF/intracytoplasmic sperm injection patients undergoing cycles stimulation (cycles 2 and 3), following initial with or alfa (cycle 1) a preceding randomized trial. In 3, 513 188 women, respectively, were treated as cycle 1, dosing based on response previous cycle.The incidence treatment-induced anti-FSH antibodies was 0.8% 1.1% which similar to 1 (1.1%). No neutralizing...
Research questionThe objective of this investigation was to determine the daily follitropin delta dose (µg) providing a similar ovarian response 150 IU/day alfa.DesignThe study post-hoc analysis in 1591 IVF/intracytoplasmic sperm injection (ICSI) patients undergoing stimulation gonadotrophin-releasing hormone antagonist protocol two recent randomized, assessor-blind, controlled trials development programme for delta: phase II dose–response trial with reference arm fixed IU alfa throughout...
The objective of this study was to demonstrate non-inferiority a highly purified urinary follicle stimulating hormone (HP-FSH) preparation compared with recombinant (rFSH) respect ovulation rate (primary end-point).This randomized, open-label, assessor-blind, multinational study. Women anovulatory infertility WHO Group II and resistant clomiphene citrate were randomized (computer-generated list) stimulation HP-FSH (n=73) or rFSH (n=78) using low-dose step-up protocol. limit prespecified at...
Summary Objective To study the association between serum anti‐Müllerian hormone ( AMH ) levels and follicular development endocrine responses induced by increasing doses (5·2–12·1μg/day) of a novel recombinant human FSH (rh , FE 999049) in patients undergoing vitro fertilization IVF )/intracytoplasmic sperm injection ICSI Gn RH antagonist protocol. Design Secondary analysis randomized controlled trial with stratified randomization according to (lower stratum: 5·0–14·9 pmol/l; higher...