A5084034597- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Iron Metabolism and Disorders
- Palliative Care and End-of-Life Issues
- Epigenetics and DNA Methylation
- Pharmacological Effects and Toxicity Studies
- LGBTQ Health, Identity, and Policy
- Health, psychology, and well-being
- Religion, Spirituality, and Psychology
- Stress Responses and Cortisol
- Cancer Treatment and Pharmacology
- Cannabis and Cannabinoid Research
- HIV/AIDS Research and Interventions
- Health disparities and outcomes
- Mental Health Treatment and Access
- Acute Lymphoblastic Leukemia research
- Management of metastatic bone disease
- Patient-Provider Communication in Healthcare
- Frailty in Older Adults
- Sleep and Work-Related Fatigue
- Indigenous Cultures and Socio-Education
- Safe Handling of Antineoplastic Drugs
- Gallbladder and Bile Duct Disorders
- Cerebral Palsy and Movement Disorders
- Dental Health and Care Utilization
Emory University
2015-2024
Children's Healthcare of Atlanta
2019-2024
Aflac (United States)
2020-2024
Center for Cancer and Blood Disorders
2016-2022
University of Pittsburgh
2008-2020
National Institute of Mental Health and Neurosciences
2019-2020
Children's Hospital of Pittsburgh
2013-2018
Mittal hospital
2015
Robert Morris University
2011
Behavioral Pharma (United States)
2010
Experimental evidence links poor sleep with susceptibility to infectious illness; however, it remains be determined if naturally occurring is associated immune responses known play a role in protection against infection. The aim of this study was determine whether duration, efficiency, and quality, assessed the natural environment, predict magnitude antibody novel antigen among community volunteers midlife. Observational. Healthy midlife adults (n = 125; 70 female; age 40-60 yr) received...
<h3>Importance</h3> The hallmark of sickle cell disease (SCD) is vaso-occlusive pain that may be acute and episodic or progress to chronic, persistent with unpredictable disabling exacerbations. Patients SCD rely on opioids almost exclusively for chronic management. <h3>Objective</h3> To understand how the current opioid epidemic subsequent guidelines from Centers Disease Control Prevention are associated management patients SCD. <h3>Design, Setting, Participants</h3> Qualitative study using...
Sickle cell disease (SCD) is an inherited blood disorder that primarily affects African-American and other ethnic minority populations. There are three available disease-modifying therapies for sickle disease: hydroxyurea (HU), bone marrow transplantation (BMT), chronic transfusion (CBT). Since these treatments vary in their therapeutic intent, efficacy preventing progression of the disease, short long-term adverse effects, costs patient burden, decision-making process regarding complicated...
To explore oncology nurses' practice behaviors and knowledge of chemotherapy-induced peripheral neuropathy (CIPN) in the assessment patients with cancer.Cross-sectional, exploratory.Two hospital-based outpatient chemotherapy clinics Baltimore, MD.Self-selected convenience sample 39 nurses.Completion principal investigator-developed questionnaire consisting 16 practice-behavior items, 8 instruction perception a 9-item demographic survey.CIPN knowledge; tool reliability.The mean CIPN score...
Sickle cell disease (SCD) is one of the most commonly inherited hemoglobin disorders that has a significant impact on quality life, increased childhood morbidity, and premature mortality. Currently, hematopoietic stem transplant (HSCT) only treatment with curative intent. The objective this study was to determine patients' caregivers' knowledge HSCT, factors influencing decision pursue their experiences, successful HSCT daily living. At Children's Healthcare Atlanta, we conducted qualitative...
Abstract Caregivers who work in community living arrangements or intermediate care facilities are responsible for the oral hygiene of individuals with intellectual and developmental disabilities. Oral training programs do not exist many organizations, despite concerns about this population. The purpose study was to determine effectiveness a caregiver educational program. This used quasi-experimental one-group pretest/posttest design repeated measures describe outcomes an Program participants...
Abstract Background Improved outcomes and the availability of clinical trials hematopoietic cell transplantation (HCT) from alternate donors genetically modified autologous progenitor cells have expanded applicability HCT for sickle disease (SCD). To understand perspective primary caregivers exploring in current milieu, we asked research question “What motivates to decide consider seek, attend, an consultation?” Procedures We conducted qualitative interviews with within one week after a...
<h3>Importance</h3> Bone marrow transplant (BMT) is a potentially curative treatment for sickle cell disease (SCD). Patient and caregiver attitudes toward BMT SCD the willingness to accept risks of vary, but these are not well understood. <h3>Objective</h3> To understand patient perceptions decision-making about BMT. <h3>Design, Setting, Participants</h3> Qualitative study interview transcripts from convenience sample. Transcripts were adults with caregivers patients recruited national...
Available modalities for the longitudinal capture and analysis of pain intensity in patients with sickle cell disease (SCD) limit our ability to study intraindividual interindividual variation factors influencing transition from acute chronic SCD.The objectives this were determine feasibility electronic outpatient data test applicability novel metrics SCD.Twenty SCD aged 13 21 submitted 2045 diary days over 229 using a web-based or through text message.Participants reported (11-point...
While acute episodic pain is the hallmark of sickle cell disease (SCD), transition to chronic a major cause morbidity and impaired quality life. One core diagnostic criteria used by Analgesic, Anesthetic, Addiction Clinical Trial Translations Innovations Opportunities Networks-American Pain Society Taxonomy (AAPT) define SCD presence on "majority days" in past 6 months one or more locations. The frequency characteristic adapted from 15 days per month, migraine, but there are inadequate data...
Hydroxyurea, chronic blood transfusions, and bone marrow transplantation are efficacious, disease-modifying therapies for sickle cell disease but involve complex risk-benefit trade-offs decisional dilemma compounded by the lack of comparative studies. A patient decision aid can inform patients about their treatment options, associated risks benefits, help them clarify values, allow to participate in medical making.The objective this study was develop a literacy-sensitive Web-based based on...
Hydroxyurea (HU) is underutilized in children with sickle cell disease (SCD) because caregivers frequently decline HU when it offered. This study explores what impacts this decision. Caregivers of clinically severe SCD whose were offered previously interviewed. We used a qualitative analytical approach to analyze their telephone interview transcripts. who chose (n = 9) reported had SCD, sought detailed information about HU, and accepted as preventative therapy. In contrast, did not choose...
Abstract Background Allogeneic hematopoietic stem cell transplantation (HCT) performed in children from human leukocyte antigen (HLA)‐identical related donors is associated with very high survival rates and disease‐free survival. Patients are exposed to gonadotoxic alkylating agents or irradiation the HCT conditioning regimen. Consequently, infertility a major long‐term complication of for sickle disease (SCD). We sought understand how caregivers perceive risk HCT, they options fertility...
Despite its efficacy, the uptake of HU in adults with sickle cell disease (SCD) is poor likely due to a combination system, provider, and patient-related factors. We investigated attitudes adult patients towards by conducting qualitative interviews 95 SCD (age 18 67 years old, 71 were female). While 53% all participants reported that they currently taking HU, ranging age 18–30 (Group 1) more report current use as compared those 2) 31–67 (65% vs. 41% P = 0.01). Most Group 1 who indicated...
Abstract Background There is a limited understanding of the patient and family experience Chronic Transfusion Therapy (CTT) for prevention complications Sickle Cell Disease (SCD). We sought to understand with CTT using qualitative methods. Methods Fifteen parents children < 18 years old nine 12–18 SCD who were receiving > 1 year interviewed semi-structured interview format, interviews analyzed open coding Results Four themes created narrative CTT: 1) Burden CTT, 2) Coping 3) Perceived...
The purpose of this qualitative descriptive study was to examine reasons for participation in clinical research among older adults with mobility limitation. A purposive sample 20 men and women aged 70 years or recruited. Data were collected by audiotaped telephone interviews using a semistructured interview guide transcribed verbatim. Participants expect privacy, professionalism staff, respectful treatment. Benefits protocol adherence include personal education, comparison their health...
To determine the acceptability, feasibility and safety of yoga for chronic pain in sickle cell disease. In Part A this two-part study, adolescents with SCD (Group 1) their parent 2) completed a survey designed to capture characteristics, attitudes practices related yoga, potential acceptability program. B, study assessed an instructor-led group The was registered on clinicaltrials.gov (NCT03694548). Eight sessions. Feasibility outcomes were chosen priori, as follows: Proportion adolescent...