A5000539923- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Viral Infections and Immunology Research
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Issues in Pregnancy
- Advanced MRI Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Radiation Dose and Imaging
- Peripheral Artery Disease Management
- Eosinophilic Disorders and Syndromes
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2024
IRCCS Ospedale San Raffaele
2024
Ospedale San Filippo Neri
2019-2023
University of Ferrara
2019-2022
Maria Cecilia Hospital
2019-2022
Azienda Sanitaria Universitaria Integrata di Trieste
2015-2022
University of Trieste
2013-2022
University of Leeds
2022
University of Padua
2022
British Heart Foundation
2022
Background An important number of patients with idiopathic dilated cardiomyopathy have dramatically improved left ventricular function optimal treatment; however, little is known about the evolution and long‐term outcome this subgroup, which shows apparent healing. This study assesses whether real healing actually exists in . Methods Results Persistent was evaluated among 408 receiving tailored medical treatment followed over very long‐term. defined as ejection fraction ≥50% indexed...
<h3>Objective</h3> To explore the genetic landscape of a well selected dilated cardiomyopathy (DCM) cohort, assessing possible relation between different genotypes and left ventricular reverse remodelling (LVRR). <h3>Methods</h3> A cohort 152 patients with DCM from Heart Muscle Disease Registry Trieste has been studied by next-generation sequencing (NGS). Patients were grouped into ‘gene-clusters’ functionally homogeneous backgrounds. LVRR was defined ejection fraction normalisation or...
The long-term progression of idiopathic dilated cardiomyopathy (DCM) in pediatric patients compared with adult has not been previously characterized. In this study, we outcome and DCM populations.Between 1988 2014, 927 were consecutively enrolled. population (aged <18 years at enrollment) included 47 participants (5.1%). At presentation, the had a significantly increased occurrence familial forms (P=0.03), shorter duration heart failure (P=0.04), lower systolic blood pressure (P=0.01),...
Abstract Background In dilated cardiomyopathy (DCM), the clinical and prognostic implications of rare variants in sarcomeric genes remain poorly understood. To address this question, we analyzed outcome gene patients enrolled our Familial Cardiomyopathy Registry. Methods DCM families harboring MYH6, MYH7, MYBPC3 , TNNT2 TTN were identified. Genotype–phenotype association analysis was performed, long‐term survival‐free from death or heart transplant compared between carriers noncarriers....
An important number of patients with idiopathic dilated cardiomyopathy have dramatically improved left ventricular function optimal treatment; however, little is known about the evolution and long-term outcome this subgroup, which shows apparent healing. This study assesses whether real healing actually exists in cardiomyopathy.Persistent was evaluated among 408 receiving tailored medical treatment followed over very long-term. Persistent defined as ejection fraction ≥50% indexed...
Women affected by Dilated Cardiomyopathy (DCM) experience better outcomes compared to men. Whether a more pronounced Left Ventricular Reverse Remodelling (LVRR) might explain this is still unknown.We investigated the relationship between LVRR and sex its long-term outcomes.A cohort of 605 DCM patients with available follow-up data was consecutively enrolled. defined, at 24-month evaluation, as an increase in left ventricular ejection fraction (LVEF) ≥ 10% or LVEF > 50% decrease indexed...
Functional mitral regurgitation (FMR) is associated with reduced survival in dilated cardiomyopathy (DCM). Cardiac resynchronization therapy (CRT) can improve FMR. We sought to identify the predictors of FMR improvement after CRT DCM.From January 2003 December 2013, 430 DCM patients consecutively enrolled were retrospectively analyzed. Inclusion criteria successful implantation presence conventional indications (i.e., left bundle branch block, ventricular ejection fraction ≤35%, New York...
Abstract Aims We evaluated the 1-year clinical events, pharmacological management, and quality of life in a contemporary cohort stable coronary artery disease (CAD) patients managed by cardiologists. Methods results START (STable Coronary Artery Diseases RegisTry) was prospective, observational, nationwide study that enrolled 5070 CAD over 3 months 183 cardiology centres Italy. At 1 year, 4790 (94.5%) had data on vital status. Death occurred 107 (2.2%) cause death cardiovascular 41 (38.3%)...
Arrhythmic risk stratification is a challenging issue in patients with dilated cardiomyopathy (DCM), particularly when left ventricular ejection fraction (LVEF) more than 35%. We studied the prevalence and predictors of sudden cardiac death or malignant arrhythmias (SCD/MVAs) DCM categorized at low arrhythmic because intermediate dysfunction under optimal medical treatment (OMT).DCM considered (LVEF >35% New York Heart Association class I-III after 6 ± 3 months OMT) were analysed. An...
Background Limited data are available on mid-range ejection fraction (mrEF) patients with dilated cardiomyopathy. We sought to define the characteristics, evolution, and long-term prognosis of cardiomyopathy mrEF at diagnosis. Methods Results analyzed all consecutively evaluated in Trieste Heart Muscle Disease Registry from 1988 2013. reduced (rEF) were defined as baseline left ventricular (LV) values between 40% 49% <40%, respectively. All-cause mortality or heart transplantation, sudden...
Abstract Aims Recently, the cardiovascular outcomes for people using anticoagulation strategies (COMPASS) trial demonstrated that dual therapy reduced compared with aspirin alone in patients stable atherosclerotic disease. Methods and results We sought to assess proportion of eligible COMPASS compare epidemiology outcome these those without inclusion or any exclusion criteria a contemporary, nationwide cohort coronary artery Among 4068 detailed information allowing evaluation eligibility,...