A5003479669- Immune Cell Function and Interaction
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
Shanghai Medical College of Fudan University
2023
Huadong Hospital
2023
Ministry of Science and Technology
2023
Fudan University
2023
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function IRG1/ITA has been established in multiple pathogen models, but very little is known cancer. Here, we show IRG1 expressed tumor-associated macrophages (TAMs) both human and mouse tumors. Mechanistically, tumor cells induce Irg1 expression by activating NF-κB pathway, ITA produced ACOD1 inhibits TET DNA dioxygenases to dampen...