A5058189188- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
Shanghai Medical College of Fudan University
2023-2024
Huadong Hospital
2023
Ministry of Science and Technology
2023
Fudan University
2023
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function IRG1/ITA has been established in multiple pathogen models, but very little is known cancer. Here, we show IRG1 expressed tumor-associated macrophages (TAMs) both human and mouse tumors. Mechanistically, tumor cells induce Irg1 expression by activating NF-κB pathway, ITA produced ACOD1 inhibits TET DNA dioxygenases to dampen...
Phenotypic plasticity is a rising cancer hallmark, and lung adeno-to-squamous transition (AST) triggered by LKB1 inactivation significantly associated with drug resistance. Mechanistic insights into AST are urgently needed to identify therapeutic vulnerability in LKB1-deficient cancer. Here, we find that ten-eleven translocation (TET)–mediated DNA demethylation elevated during KrasLSL-G12D/+; Lkb1L/L (KL) mice, knockout of individual Tet genes reveals Tet2 required for squamous transition....