A5033317569- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced biosensing and bioanalysis techniques
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Metal-Organic Frameworks: Synthesis and Applications
- Biomarkers in Disease Mechanisms
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Energy and Environment Impacts
- Galectins and Cancer Biology
- Air Quality and Health Impacts
- Genetic factors in colorectal cancer
- Endoplasmic Reticulum Stress and Disease
- Cancer Genomics and Diagnostics
- Seed Germination and Physiology
Center for Excellence in Molecular Cell Science
2024
Chinese Academy of Sciences
2024
Shandong Maternal and Child Health Hospital
2020
Jiangsu University
2019
Integrated Chinese Medicine (China)
2017
Northwest Women's and Children's Hospital
2013
Human lung adenosquamous cell carcinoma (LUAS), containing both adenomatous and squamous pathologies, exhibits strong cancer plasticity. We find that ALK rearrangement is detectable in 5.1–7.5% of human LUAS, transgenic expression EML4-ALK drives adenocarcinoma (LUAD) formation initially transition at late stage. identify club cells as the main cell-of-origin for transition. Through recapitulating lineage organoid system, we JAK-STAT signaling, activated by phase separation, significantly...
Phenotypic plasticity is a rising cancer hallmark, and lung adeno-to-squamous transition (AST) triggered by LKB1 inactivation significantly associated with drug resistance. Mechanistic insights into AST are urgently needed to identify therapeutic vulnerability in LKB1-deficient cancer. Here, we find that ten-eleven translocation (TET)–mediated DNA demethylation elevated during KrasLSL-G12D/+; Lkb1L/L (KL) mice, knockout of individual Tet genes reveals Tet2 required for squamous transition....
ABSTRACT Formaldehyde, a ubiquitous environmental pollutant, has long been suspected of causing adverse male reproductive effects. However, the molecular and cellular mechanisms underlying this phenomenon remain elusive. The overall aim study is to clarify role autophagy in injuries induced by formaldehyde exposure, which we can further understand mechanism spermatogenesis develop new targets for prevention treatment infertility. In study, electron microscopy, Western blot, RT‐PCR analysis...
Long non-coding RNAs (lncRNAs) exert critical effects in the process of malignant cancers and lncRNA LOXL1 Antisense RNA 1 (LOXL1-AS1) has been demonstrated to be a pro-oncogene multiple tumor types. In current study, we illuminated precise roles LOXL1-AS1 development ovarian cancer. is significantly overexpressed carcinoma tissue compared with adjacent non‐cancerous sample. The luciferase reporter gene assay reveals relationship between miR‐18b‐5p, miR‐18b‐5p its target gene, Vacuolar...
To explore the mechamisms of mitochondria-mediated pathway in apoptosis platelets resulted from immune induced bone marrow failure.Thirty C57BL/6 mice were randomly divided into 3 groups (10 each group): normal group, model cyclosporine A(CsA) group. Mouse failure established. After mouse was successfully established, group and given saline orally, CsA treated with orally. Blood routine examination performed by automatic blood cell analyzer; mitochondrial membrane potential(ΔΨm), cytochrome...