A5038329314- Transportation Planning and Optimization
- Transportation and Mobility Innovations
- Reproductive Biology and Fertility
- Railway Systems and Energy Efficiency
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer-related molecular mechanisms research
- Traffic control and management
- Reproductive Health and Technologies
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Urban Transport and Accessibility
- COVID-19 Clinical Research Studies
- Ear Surgery and Otitis Media
- Sperm and Testicular Function
- Asymmetric Hydrogenation and Catalysis
- Advanced Manufacturing and Logistics Optimization
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Electric Vehicles and Infrastructure
- Urban and Freight Transport Logistics
- CAR-T cell therapy research
- Scheduling and Optimization Algorithms
- Quinazolinone synthesis and applications
- Hormonal and reproductive studies
Nantong University
2019-2025
Guangzhou Medical University
2022-2025
State Key Laboratory of Respiratory Disease
2022-2025
Tsinghua University
2020-2024
Ministry of Agriculture and Rural Affairs
2024
Southern Medical University Shenzhen Hospital
2017-2023
Renmin Hospital of Wuhan University
2006-2022
Wuhan University
2006-2022
University of Auckland
2019-2022
University of International Business and Economics
2022
Abstract Immune checkpoint blockade therapies have shown clinical promise in a variety of cancers, but how tumor-infiltrating T cells are activated remains unclear. In this study, we explore the functions PD-L1 on dendritic (DCs), which highly express PD-L1. We observe that DC plays critical role limiting cell responses. Type 1 conventional DCs essential for and they upregulate upon antigen uptake. Upregulation is mediated by type II interferon. While major presenting cross-presenting tumor...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global crisis, urgently necessitating the development of safe, efficacious, convenient-to-store, and low-cost vaccine options. A major challenge is that receptor-binding domain (RBD)-only fails to trigger long-lasting protective immunity if used alone for vaccination. To enhance antigen processing cross-presentation in draining lymph nodes (DLNs), we developed an interferon (IFN)-armed RBD dimerized by...
The development of practical and selective strategies for deuterium incorporation to construct deuterated molecules, particularly deuterium-labeled amino acids, has become as a growing focus basic research, yet it remains formidable challenge. Herein, we present bioinspired calcium-HFIP-mediated site-selective reductive deutero-amination α-oxo-carbonyl compounds with amines. Utilizing d2-Hantzsch ester the source, this reaction attains remarkable deuteration efficiency (> 99% deuteration)....
The ginsenoside compound K (20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol; CK) is an intestinal bacterial metabolite of ginseng protopanaxadiol saponin that has been reported to induce apoptosis in many cancer cells; however, the precise mechanisms its activity human hepatocellular carcinoma (HCC) cells remain unclear. Herein, we demonstrated CK inhibited growth and colony formation HepG2 SMMC-7721 cells, phenotypes were mediated by inducing apoptosis. Meanwhile, showed lower toxicity normal...
This paper proposes an integrated optimization model for vessel scheduling and routing. The objective is to maximize shipping company profits while considering profit volatility using the Conditional Value-at-Risk metric master risks from demand fluctuations. Simultaneously, balances spot contract container allocation by optimally adjusting speeds so as minimize carbon emissions. We account deployment, chartering costs, delay penalties, fuel expenses, weather conditions ensure model’s...
Abstract Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age. It characterized by hyperandrogenism, ovulatory dysfunction, and the presence polycystic ovarian morphology (PCOM) on ultrasound, often accompanied metabolic disturbances such as insulin resistance obesity. Current treatments, including oral contraceptives anti-androgen medications, yield limited efficacy undesirable side effects. This study investigates role UGT2B15, an...
This study provides a novel solution for the synchronized and coordinated railway scheduling optimization (SCSO) problem by determination of departure times public transit network. Railway timetable is dealt with maximizing number meetings to allow smooth transfers at interchanges. The developed model uses binary variables record considering importance transfer stations rail lines without need apply modeling passenger assignments. allows permissible flexible waiting time making connection...
This study aimed to demonstrate that ginsenoside compound K (20 (S)-ginsenoside CK; CK) downregulates Bcl-2-associated transcription factor 1 (Bclaf1), which inhibits the hypoxia-inducible factor-1α (HIF-1α)-mediated glycolysis pathway inhibit proliferation of liver cancer cells. Treatment hepatoma cells (Bel-7404 and Huh7) under hypoxic conditions with different concentrations CK showed inhibited in a time- concentration-dependent manner; furthermore, ability form colonies was reduced, cell...
Urban rail transit (URT) demand often exhibits tidal or centripetal shapes during peak/off-peak hours. Inefficiency occurs when the supply of service is not adjusted to fluctuating demand. This optimization can be realized by redesigning URT timetables and/or through operational strategies. Certainly, implementation optimal/best-adjusted must feasible in order accommodate efficient operations planning. work develops a new methodology derive an optimal timetabling design procedure for...
Abstract An ideal DNA‐encoded library (DEL) selection requires the to consist of diverse core skeletons and cover chemical space as much possible. However, lack efficient on‐DNA synthetic approaches toward has greatly restricted diversity DEL. To mitigate this issue, work disclosed a “Mask & Release” strategy streamline challenging skeleton synthesis. N ‐phenoxyacetamide is used masked phenol versatile directing group mediate diversified DNA‐compatible C‐H functionalization, introducing...
Abstract Endometriosis is considered a benign gynaecological disease with cancer‐like characterizations, which has high incidence among women of reproductive age. However, this so far lacked timely diagnosis and effective treatment owing to its unclear aetiology. In study, we identified aberrant expression circ_0007331 in ectopic endometrial cells by comparing the samples from patients without endometriosis. Further functional experiments revealed that knock‐down effectively suppressed...
Stop-skipping is a key method for alleviating congestion in rail transit, where schedules are sometimes difficult to implement. Several mechanisms have been proposed and analyzed the literature, but very few performance comparisons available. This study formulated train choice behavior estimation into model considering passengers' perception. If passenger's path can be identified, this information would useful improving stop-skipping schedule service. Multi-performance characteristic of our...
During in vitro fertilization, rapid growth of vitrification and liquid nitrogen storage embryos have been well characterized. However, the effect time on vitrified cleavage-stage an open system is poorly understood.To investigate influence survival pregnancy outcomes human froze stored system.A retrospective study 786 vitrified-warmed cycles 735 patients was performed from January 2013 to October 2013. The were divided into five groups according time: 1-3 months, 4-6 7-12 13-24 25-60...
Abstract To evaluate the relationship between positions of cytoplasmic granulation and oocytes developmental potential in human, we detected potentials with centrally located (CLCG). The patients’ age, body mass index (BMI), Infertility duration, follicle stimulation hormone (FSH) levels, average stimulate ovulation days, gonadotropin (GN) total dose, fertilization rate, cleavage high quality embryo utilization rate pregnancy were analyzed. results showed that there no significant difference...
To discuss the relationship between triploidy incidence and clinical outcomes of embryos derived from normally fertilized oocytes same cohort for in vitro fertilization-embryo transfer (IVF-ET) cycles different ovarian stimulation protocol.This study included 2070 fertilization (IVF) with long-term protocol, 802 IVF ultra short-term protocol 508 IVF-D (in by donor semen) January 2013 to September 2014. According 3PN rate, patients were divided into three groups as follows: Group 1 0%...
Even-headway and even-load timetables have been in practice for the past 50 years. The former stipulates constant departures to cultivate users' habits accordingly, whereas latter is oriented from demand regulations aiming further reduce waiting times. However, striking balance between operation reliability (derived even-headway timetabling) an on-demand response passenger fluctuation (referring requires addressing major challenges presented by peak or alternatively off-peak demands. Our...
Urban public transport line formulation has its appeal in promoting convenience and developing environmentally friendly cities. During the bus planning stage, frequency stop location determination is a key issue for decision makers. Our study focuses on integrated problem between featuring multi-type vehicles. The vehicles are able to accommodate various passenger demands at either peak hours or off-peak hours. priori magnitudes of user investigated by drone-based technique methods...