A5103266120- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Gamma-ray bursts and supernovae
- Ferroptosis and cancer prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
Chinese Academy of Sciences
2023-2024
Center for Excellence in Molecular Cell Science
2024
Shanghai Institute of Technical Physics
2023
Institute of High Energy Physics
2023
Phenotypic plasticity is a rising cancer hallmark, and lung adeno-to-squamous transition (AST) triggered by LKB1 inactivation significantly associated with drug resistance. Mechanistic insights into AST are urgently needed to identify therapeutic vulnerability in LKB1-deficient cancer. Here, we find that ten-eleven translocation (TET)–mediated DNA demethylation elevated during KrasLSL-G12D/+; Lkb1L/L (KL) mice, knockout of individual Tet genes reveals Tet2 required for squamous transition....
Abstract The central engine that powers gamma-ray bursts (GRBs), the most powerful explosions in universe, is still not identified. Besides hyper-accreting black holes, rapidly spinning and highly magnetized neutron stars, known as millisecond magnetars, have been suggested to power both long short GRBs 1–7 . presence of a magnetar following compact star mergers particular interest it would provide essential constraints on poorly understood equation state for stars 8, 9 Indirect indications...