A5038554702- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Cyclopropane Reaction Mechanisms
- Advanced Sensor and Energy Harvesting Materials
- Asymmetric Hydrogenation and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Electrospun Nanofibers in Biomedical Applications
- Synthesis and Biological Evaluation
- Organoboron and organosilicon chemistry
- Polymer Nanocomposites and Properties
- Conducting polymers and applications
- Hydrogels: synthesis, properties, applications
- Polymer crystallization and properties
- Synthetic Organic Chemistry Methods
- Fluorine in Organic Chemistry
- Catalytic Alkyne Reactions
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Organoselenium and organotellurium chemistry
- Organic Light-Emitting Diodes Research
Zhengzhou University
2016-2025
East China University of Science and Technology
2022
Athinoula A. Martinos Center for Biomedical Imaging
2019
Massachusetts General Hospital
2019
Henan University
2011
This work provides a new method to prepare poly(vinyl alcohol) (PVA) hydrogel. Compared with the traditional repeated freeze–thaw method, physical cross-linking was adopted high-strength hydrogel in one step. The morphology, melting, and crystallization behavior mechanical properties of were investigated. has high water content reswelling rate, as well melting temperature strength. It also stable cross-linked structure range 25–65 °C. fracture surface shows ductile brittle morphology....
ABSTRACT The curing energy consumption of traditional phenolic resin (PF) is high, and rapid modification required. mechanism also requires further investigation. In this work, the reaction process functional application curing‐accelerated modified resins are studied. Phenol‐resorcinol‐formaldehyde (PRF) resin, sodium bicarbonate‐accelerated PRF (PRF‐SB) zinc oxide‐catalyzed high‐ortho‐phenol‐resorcinol‐formaldehyde (HOPRF) synthesized via in situ polymerization. addition resorcinol oxide...
Efficient and facile catalytic protocols for chlorination ligand-directed ortho-acetoxylation of 2-arylbenzoxazoles have been developed. The is not a ortho-functionalization, but an electrophilic substitution process in the benzo ring benzoxazole moiety. Meanwhile, acetoxylation exhibited high regioselectivity substrates containing meta-substituent occurred at less sterically hindered ortho-C–H bond directing group.
A highly efficient method for synthesis of difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic acid as reaction substrates has been developed through radical cascade cyclization. The advantage this strategy lies in excellent functional group tolerance to generate the corresponding products good yields under base- and metal-free conditions.
Microparticles (MPs) and amorphous solid dispersions (SDs) are effective methods to improve the dissolution of insoluble drugs. However, stability is a concern for these two high-energy systems, resulting from high surface area polymorph, respectively. As an amphiphilic polymer, Soluplus (SOL) usually used as carrier in SDs. In this study, erlotinib microparticles (ERL MPs) SDs) were prepared with SOL by bottom-up technology solvent evaporation. The solid-state properties ERL MPs SDs...
Abstract Polyvinyl alcohol (PVA) and polyacrylamide (PAM) hydrogels as well silver particles (Ag) composites are prepared by compound gelation. The structure properties of the composites, which controlled reaction acrylamide in hydrogel, analyzed feasibility their application strain sensors explored. effects different PVA concentration, content, particle size Ag on mechanical properties, rheological studied. PVA/PAM/Ag selected substrate sensor, when concentration is 0.08 g/ml, 60 nm...
ABSTRACT A composite of poly(ethylene oxide) (PEO) and lignin (Lg) was prepared characterized for its utility as an ultraviolet (UV) absorbing material. Due to the extensive UV absorption excellent oxidation‐resistance Lg, formation hydrogen bonds between Lg particles PEO molecular segments renders well‐dispersed in matrix. PEO/Lg composites with different contents show that high levels could cause defects at interface. The viscosities all were higher than pure PEO. Composite foams further...
Abstract An effective strategy for construction of 1,5‐dihydro‐2H‐pyrrol‐2‐one scaffolds by a cascade 1,5‐dienes with cyclobutanone oxime esters was developed. The reaction proceeded through radical addition, 5‐endo cyclization, and subsequent deprotonation, in which two new C−C bonds were formed. This protocol features excellent regioselectivity low‐cost catalyst, as well broad substrate scope, are expected to promote its potential applications pharmacy synthetic chemistry.
A visible‐light‐mediated synthesis of 3‐alkyl‐ substituted chroman‐4‐one derivatives via deaminative alkylation amino acid derived Katritzky salts and tandem cyclization with o‐(allyloxy)arylaldehydes has been developed. This approach exhibits a certain functional‐group compatibility 31 examples affords desired products in yields 16% to 88%. Mechanistic research results suggests that the formation EDA complexes between base is main reason for initiating reaction.
Abstract A new environmentally friendly and efficient strategy for preparing trifluoromethylated pyrrolidones has been developed. The process involves using visible light to induce radical cyclization of 1,5‐dienes with CF 3 SO 2 Na, resulting in excellent regioselectivity. This method uses less expensive easy‐to‐store trifluoromethylation reagents, making it an attractive option. Additionally, the can be easily modified preliminary mechanistic studies have presented.
Abstract An efficient palladacycle‐catalyzed aromatic carbonylation reaction of aryl formates with iodides or bromides has been developed. Commercially available and easily prepared were employed as carbonyl sources without the use external carbon monoxide. The present catalytic system shows broad functional group tolerance affords benzoate derivatives in good to excellent yields.
A visible-light-induced radical cyclization of α-brominated amides has been developed to construct benzimidazole[2,1-
A copper-catalyzed reaction protocol for the dehydrogenation of ethylbenzenes into styrene derivatives has been developed. This procedure proceeded well under mild conditions, providing a practical and efficient strategy rapid assembly biologically pharmaceutically significant molecules, such as vinyl sulfone. Simple alkyl arenes were functionalized via consecutive β-elimination in presence N-sulfonylbenzo[d]imidazole with broad substrate scope good functional group tolerance.
Abstract A novel, efficient and transition‐metal‐free alkylation of enol acetates by radical decarboxylation N‐hydroxyphthalimide esters to synthesize α‐alkylated ketones in existence Na 2 ‐eosin Y at room temperature has been developed. This methodology features operational simplicity, mild reaction conditions, widely functional group tolerance, affording a diverse array moderate good yields.
A metal‐free mediated oxidative acylation of α,α‐diarylallylic alcohols with simple aromatic aldehydes for the synthesis 1,2,4‐triphenylbutane‐1,4‐diones is presented. In presence TBPB ( tert ‐butyl peroxybenzoate), desired products were obtained in good to excellent yields 28 examples. This protocol features high regioselectivity, wide functional group tolerance and atom economy.
Firstly, the polyvinyl alcohol/polyacrylic acid double network hydrogels were prepared by physical and chemical cross-linking, then polyethylene glycol, chitosan, hydroxypropyl methyl cellulose added to construct multiple hydrogels. The intermolecular chains entangled with each other force was gathered at cross-linking point, which greatly improved mechanical strength of hydrogel. Intensity can be regulated adjusting variables. method used in this paper is simple hydrogel has better...
A medical microneedle candidate material is prepared bases on polylactic acid (PLA), poly(ethylene glycol) (PEG), and low content of multi-walled carbon nanotubes (MWCNT) composites. successive self-nucleation annealing analysis was applied the presence PEG MWCNT ratio had a significant influence processability PLA. The composites show much better tensile strength elongation at break than pure Based good balance high superior toughness, polymer can be potential for microneedle.