A5065808213- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Diabetes Treatment and Management
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Inflammatory mediators and NSAID effects
- Cytomegalovirus and herpesvirus research
- Inflammatory Bowel Disease
- Chronic Myeloid Leukemia Treatments
- Mycobacterium research and diagnosis
- Hematopoietic Stem Cell Transplantation
- Herpesvirus Infections and Treatments
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Cardiac electrophysiology and arrhythmias
- Chronic Kidney Disease and Diabetes
- Gastrointestinal motility and disorders
- Blood disorders and treatments
- Potassium and Related Disorders
- Liver Diseases and Immunity
- Ear Surgery and Otitis Media
- Autoimmune and Inflammatory Disorders
- Animal Virus Infections Studies
Okayama University Hospital
2018-2025
Osaka Women's and Children's Hospital
2024
Okayama University
2023
Kindai University Hospital
2022
Toho University
2012-2021
Pharmac
2021
Pediatrics and Genetics
2020
Osaka Medical and Pharmaceutical University
2013-2018
National Hospital Organization
2012-2016
Osaka Medical Center for Cancer and Cardiovascular Diseases
2016
The family Coronaviridae comprises a monogeneric group of 11 viruses which infect vertebrates. main characteristics the member are: (i) Morphological: Enveloped pleomorphic particles typically 100 nm in diameter (range 60-220 nm), bearing about 20 long club-shaped surface projections. (ii) Structural: A single-stranded infectious molecule genomic RNA (5-7) X 10(6) molecular weight. phosphorylated nucleocapsid protein [mol. wt. (50-60) 10(3)] complexed with genome as helical...
British Journal of HaematologyEarly View IMAGES IN HAEMATOLOGY Paediatric anaplastic large-cell lymphoma with cardiac tamponade Takahiro Shiwaku, Corresponding Author Shiwaku [email protected] orcid.org/0009-0001-0900-1953 Department Pediatrics, Okayama University Hospital, Okayama, Japan Email: protected]Search for more papers by this authorKosuke Tamefusa, Kosuke Tamefusa orcid.org/0000-0002-1675-7038 JapanSearch authorHisashi Ishida, Hisashi Ishida orcid.org/0000-0002-3391-8403...
Cerebrospinal fluids (CSFs) from 9 Pug dogs with necrotizing meningoencephalitis (NME: dog encephalitis) were examined to identify the antigens for anti-astrocyte autoantibodies. Each CSF exhibited a positive reaction cytoplasm of cultured canine astrocytes by an indirect fluorescent antibody test. In immunoblotting analysis on normal brain proteins, eight CSFs showed common band 52 kDa, corresponding glial fibrillary acidic protein (GFAP), and all reacted purified bovine GFAP. From these...
Luminal nutrients stimulate enteroendocrine L cells to release gut hormones, including intestinotrophic glucagon-like peptide-2 (GLP-2). Because express the bile acid receptor TGR5 and dipeptidyl peptidase-IV (DPPIV) rapidly degrades GLPs, we hypothesized that luminal activation may attenuate intestinal injury via GLP-2 release, which is enhanced by DPPIV inhibition.Intestinal was induced in mice administration of dextran sulfate sodium (DSS) drinking water (free access containing 5% DSS for...
To examine the prevalence of autoantibody in canine cerebrospinal fluids (CSFs), CSFs were collected from 14 healthy controls and 88 clinical cases with various diseases central nervous system (CNS), analyzed by an indirect fluorescence antibody test on frozen sections cerebrum normal Beagle dogs. An anti-astrocyte was detected 31 titers ranging 1:1 to ≥1:100. All tested necrotizing meningoencephalitis (NME: n=22) granulomatous (GME: n=3) possessed autoantibody, while negative most other...
Cytomegalovirus (CMV) infection is a major complication of hematopoietic stem cell transplantation (HSCT). Previous studies in adults demonstrated that letermovir prophylaxis for 100 d after HSCT reduces the occurrence CMV infection; however, children are limited. In this study, we aimed to examine incidence who underwent allogeneic with prophylactic therapy. A single-center retrospective study was conducted among patients aged ≤17 HSCT. We compared cumulative infection, mainly monitored by...
The gut incretin glucagon-like peptide-1 (GLP-1) and the intestinotropic hormone GLP-2 are released from enteroendocrine L cells in response to ingested nutrients. Treatment with an exogenous analogue increases intestinal villous mass prevents injury. Since is rapidly degraded by dipeptidyl peptidase 4 (DPP4), DPP4 inhibition may be effective treatment for ulcers. We measured mRNA expression DPP enzymatic activity segments. Mucosal GLP concentrations were after administration of inhibitor...
The relationship between type 2 diabetes mellitus and intestinal neoplasia has been shown epidemiologically. A high-fat diet (HFD) is also known to promote insulin resistance, which a risk factor for neoplasia. Dipeptidyl peptidase-4 (DPP-4) inhibitors are used in the clinic treatment of prolong effects glucagon-like peptide-1 (GLP-1). However, since intestinotrophic hormone GLP-2 chemokines, such as CXCL5 stromal cell-derived factor-1 (SDF-1), substrates DPP-4, DPP-4 may increase...
Abstract Objective This study primarily focused on the diagnostic interval (DI), defined as duration from onset of leukemic symptoms to diagnosis. We investigated whether a prolonged DI is associated with outcomes pediatric leukemia. Methods retrospectively collected data children newly diagnosed leukemia at Okayama University Hospital January 2007 December 2022. Survival analyses were conducted using Kaplan–Meier methods, and an unadjusted analysis compare differences in survival was...
A strain of Fusarium solani was isolated from a dog showing many cutaneous and submucosal nodules pyogranulomatous kidney lesions. Clinical isolates this systemic infection were identified using microscopic examination confirmed by molecular analysis.
Toxic megacolon is an infrequent but life-threatening complication that occurs most commonly in patients with severe ulcerative colitis. Intravenous steroids are often recommended for toxic secondary to However, steroid dependency may mask the presence of intra-abdominal sepsis and associated refractoriness, during which cytomegalovirus reactivation occur. In this report, we present two rare cases accompanying pancolonic colitis were successfully treated oral tacrolimus, including one...
Neonatal Bartter syndrome (NBS) is an inherited renal tubular disorder associated with hypokalemic alkalosis. Here we report a case of genetically diagnosed NBS. Polyhydramnios was noted at 26 weeks. A boy born 31 weeks and 1 day, weighed 1344 g, had Apgar score 8/8. We initiated indomethacin (IND) dose 0.2 mg/kg/d on day 31, increased it to approximately 3 mg/kg/d. However, his urinary calcium (Ca) levels remained unchanged. At 4 months age, nephrocalcinosis detected by ultrasound. The...
Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing permeability mucosa. However, therapeutic strategies for patients with low-dose aspirin-induced small intestinal injury have not been determined. We evaluated preventative effect egualen sodium hydrate, a gastro-protective agent that suppresses indomethacin-induced small-intestinal damage in rats, against mucosal induced aspirin healthy adult male...
Crohn's disease (CD) is characterized by transmural inflammation of the gastrointestinal tract, which predisposes patients to formation a fistula. The efficacy adalimumab (ADA) for an enterocutaneous fistula remains unclear. In this report, we present case series 3 with fistulizing CD treated ADA. ADA treatment achieved sustained complete closure in one patient. other two cases, failed achieve closure, had intestinal stenosis and were not receiving concomitant azathioprine. Combination...