A5019387824- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Nanoplatforms for cancer theranostics
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Inflammatory mediators and NSAID effects
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Esophageal and GI Pathology
- Nanoparticle-Based Drug Delivery
- Eosinophilic Esophagitis
- Radiopharmaceutical Chemistry and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced Radiotherapy Techniques
- Gastrointestinal motility and disorders
- Pathogenesis and Treatment of Hiccups
- Gastrointestinal disorders and treatments
- Urinary and Genital Oncology Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Prostate Cancer Diagnosis and Treatment
- Trace Elements in Health
Kagawa University
2021-2025
Osaka University of Pharmaceutical Sciences
2025
National Hospital Organization
2022-2024
Osaka University
2024
Iwate Medical University
2014-2023
IRYO Sosei University
2022
St. Cloud State University
2022
Kishiwada City Hospital
2018-2021
Osaka Medical and Pharmaceutical University
2013-2021
St. Marianna University School of Medicine
2020-2021
Analysis of cellular components at multiple levels biological information can provide valuable functional insights. We performed high-throughput measurements to study the response Escherichia coli cells genetic and environmental perturbations. metabolic enzyme gene disruptants revealed unexpectedly small changes in messenger RNA proteins for most disruptants. Overall, metabolite were also stable, reflecting rerouting fluxes network. In contrast, E. actively regulated maintain a stable state...
A sulfonated diamine monomer, 4,4'-diaminodiphenyl ether-2,2'-disulfonic acid (ODADS), was successfully synthesized by direct sulfonation of a commercially available diamine, ether (ODA), using fuming sulfuric as the sulfonating reagent. series polyimides were prepared from 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTDA), ODADS, and common nonsulfonated diamines. The resulting displayed much better stability toward water than those derived widely used 2,2'-benzidinedisulfonic (BDSA)....
Objectives To examine prostate cancer staging in real‐world clinical practice. Methods We retrospectively analyzed 698 patients referred to the Department of Urology at Kagawa University Hospital from 25 facilities for treatment June 2014 December 2023. Patients treated with dutasteride ( n = 10) and who underwent our institution 197) were excluded. The outcomes interest proportion computed tomography bone scintigraphy, diagnostic rates metastasis stratified by D'Amico risk, incidental...
There is a lack of consensus regarding the risk postoperative hemorrhage in patients on antithrombotic therapy who undergo endoscopic submucosal dissection (ESD). We examined bleeding rates and factors for from post-ESD gastric ulcers therapy. The subjects this study were 833 underwent ESD tumors. Of these, 743 not 90 some form (46 low-dose aspirin (LDA) only, 23 LDA + thienopyridine, 21 warfarin). All commenced proton pump inhibitor (PPI) immediately postoperatively. Antiplatelet agents...
Summary Background Vonoprazan (V), a potassium‐competitive acid blocker, has more durable acid‐inhibitory effect as compared with standard‐dose proton pump inhibitors (PPIs) but not been 2‐4 times higher daily PPI doses administered in two divided doses. Aims To evaluate the of V 10/20 mg once‐daily (OD; V10/V20) vs rabeprazole (R) twice‐daily (BID; R20/R40) healthy Japanese volunteers. Methods This multicentre, randomised, open‐label, two‐period, crossover study V10 or V20 R20, R40 using...
Abstract Endoscopic injection sclerotherapy (EIS) is a useful prophylactic hemostatic procedure for esophageal varices. However, injecting sclerosing agents into blood vessels technically challenging and often ineffective. Gel‐immersion EIS (GI‐EIS) may facilitate easier intravascular agent by dilating the varices enhancing scope stability maintaining low intra‐gastrointestinal pressure. Therefore, we aimed to evaluate effectiveness safety of this procedure. This retrospective study included...
Background/Objectives: The objective of this study was to evaluate the oncological outcomes and safety nerve-sparing (NS) robot-assisted radical prostatectomy (RARP) when applied without Prostate Imaging-Reporting Data System (PI-RADS) ≥3 lesions or Gleason pattern ≥4 on biopsy in peripheral zone (PZ). Methods: We retrospectively analyzed 208 patients who underwent RARP between August 2017 December 2022, excluding those had received preoperative hormonal therapy. After NS status...
The Paris System (TPS) for reporting urinary cytology differs from conventional systems (CS) in that it focuses on the diagnosis of high-grade urothelial carcinoma (HGUC). This study investigated impact TPS implementation diagnostic accuracy HGUC by comparing with our institutional CS.
5-aminolevulinic acid is a protoporphyrin IX precursor used for photodynamic diagnosis. We aimed to clarify the therapeutic benefits of orally administered diagnosis in transurethral resection non-muscle-invasive bladder cancer real-world setting. From January 2009 December 2020, patients with who have undergone visually complete by initial surgery were included. Histopathologically confirmed residual and intravesical recurrent was retrospectively investigated compared using conventional...
Objectives: Although drug treatment is the usual first-line therapy for gastroesophageal reflux disease (GERD), not all patients receive satisfactory relief from therapy, alone. We developed an endoscopic fundoplication technique using submucosal dissection (ESD); referred to as ESD GERD (ESD-G). This study investigated safety and efficacy of this novel in with drug-refractory GERD. Patients methods: ESD-G narrows hiatal opening through esophagogastric junction (EGJ) mucosa. For reasons,...
Background/Aims: Phase III study demonstrated that vonoprazan-based Helicobacter pylori eradication therapy achieved higher rate compared with lansoprazole. However, there is no evaluated the efficacy of vonoprazan in a large sample real world. We investigated and safety our randomized control trial using second-generation proton pump inhibitor (PPIs). Methods: (First study) A total 147 patients who have H. infection were randomly assigned to receive either, esomeprazole (EPZ) group...
In nano-imprint lithography, durability of the mold is one most important factors for industrial application. We demonstrate replicated fabrication integrated fine patterns based on a Si/SiO2 master mold. The replication performed by Ni electroless plating and electroforming process 1 in.2 field. Fine as small 250 nm in width 270 height have been successfully without fatal defects such cracks or voids. Using mold, obtained imprint lithography. surface roughness relatively poor compared with...
Fabrication of patterns with curved cross-sectional profiles for diffractive optical elements are demonstrated by imprint lithography using replicated Ni mold. The master mold pattern is fabricated an electron beam lithography, where dosage distribution automatically optimized a computer aided design (CAD) system taking the proximity effects and resist development process into account. Utilizing CAD system, modulated pitched polynomial shaped successfully obtained poly (methylmethacrylate)...
Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause epithelial cell damage in the stomach, intestine, and colon. NSAIDs are reported to induce autophagy apoptosis intestinal cells; however, their role is poorly understood. To examine of damage, we used autophagy-related gene <i>Atg5</i>-conditional knockout mice, which <i>Atg5</i> only knocked out cells. In an indomethacin (IM)–induced gastrointestinal ulcer mouse model, epithelium was reduced mice compared with wild-type mice....
Background Well Parent Japan (WPJ) is a new hybrid group parent training programme combining sessions to improve mothers' psychological well‐being with culturally adapted version of the New Forest Parenting Programme (NFPP). This study investigates effectiveness and cost‐effectiveness WPJ against treatment as usual (TAU) within Japanese child mental health services. Methods TRANSFORM was pragmatic multi‐site randomised controlled trial (RCT) two parallel arms. Altogether 124 mothers...
Type III IP3 receptor (IP3R3) is one of the common critical calcium-signaling molecules for sweet, umami, and bitter signal transduction in taste cells, total IP3R3-expressing cell population represents all cells mediating these modalities buds. Although gustducin, a cell–specific G-protein, also involved transduction, expression gustducin restricted to different subsets by location tongue. Based on patterns receptors tongue, function has been implicated primarily circumvallate (CV) papillae...
Abstract Background and Aim Gastroesophageal reflux disease (GERD) functional dyspepsia (FD) often coexist or overlap. In this study, the efficacy of acotiamide in combination with a standard dose rabeprazole for GERD FD was compared that double rabeprazole. Methods Patients overlap between experiencing heartburn epigastric fullness symptoms after standard‐dose proton pump inhibitor (PPI) ≥ 8 weeks were randomized into two groups received either 300 mg/day + 10 20 4 weeks. Efficacy assessed...
Small intestinal mucosal injury caused by low-dose aspirin is a common cause of obscure gastrointestinal bleeding. We aimed to investigate the protective effects and optimal dose rebamipide for aspirin-induced injury. In this prospective randomized trial, 45 healthy volunteers (aged 20-65 years) were included divided into three groups. The groups received enteric-coated 100 mg (low-dose aspirin) plus omeprazole 10 (Group A: proton pump inhibitor group), 300 B: standard-dose or 900 C:...
Abstract The opportunistic fungal pathogens Candida inconspicua and C. norvegensis are very rarely isolated from patients resistant to fluconazole. We collected 38 strains of the two microorganisms Europe Japan, compared polymorphism rRNA intergenic spacer (IGS) internal transcribed (ITS) regions, antifungal drug susceptibility, extracellular enzyme production as a potential virulence factor. While IGS sequences were not divergent (more than 96.7% sequence similarity among strains), those...
Abstract Background and Aim Proton‐pump inhibitors are known to be effective in the treatment prevention of ulcers related low‐dose aspirin ( LDA ), but few reports address H 2 ‐receptor antagonists H2RA s) gastroprotective agents GP s). This study was intended compare therapeutic effects an a against gastroduodenal mucosal injuries patients taking . Methods The subjects consisted requiring continuous treatment, whom no peptic ulcer found on endoscopy at enrollment. were randomized either...
We aimed to investigate how high-dose ecabet sodium affects low-dose aspirin-induced small intestinal mucosal injury in healthy volunteers. Healthy volunteers were enrolled randomly into one of two groups with the following drug regimens for 2 weeks: group A, aspirin once per day and B, 4.0 g sodium. Small bowel capsule endoscopy was performed before weeks after administration. A significant difference found median number [range] lesions between baseline administration (baseline: 1 [0–5],...