A5085724243- Computational Drug Discovery Methods
- Studies on Chitinases and Chitosanases
- Click Chemistry and Applications
- Nematode management and characterization studies
- Insect Resistance and Genetics
- HIV/AIDS drug development and treatment
- Invertebrate Immune Response Mechanisms
- Synthesis and biological activity
- Fungal Plant Pathogen Control
- Entomopathogenic Microorganisms in Pest Control
- Pharmacogenetics and Drug Metabolism
- Insect and Pesticide Research
- thermodynamics and calorimetric analyses
- Pneumocystis jirovecii pneumonia detection and treatment
- Insect symbiosis and bacterial influences
- Legume Nitrogen Fixing Symbiosis
China Agricultural University
2020-2022
Chitinase is one of the most important glycoside hydrolyases, widely existing in bacteria, fungi, insects, and plants. It involved fungal cell wall remodeling insect molting. inhibitors are an effective means controlling pathogens pests. Natural product argifin a 17-membered pentapeptide that exhibits efficient chitinase inhibitory activity. However, complexity synthetic process results lot restrictions for wide range applications. In this work, we designed series azamacrolide based on...
Abstract To discover new nematicidal succinate dehydrogenase (SDH) inhibitors with novel structures, we conducted a virtual screening of the ChemBridge library 1.7 million compounds based on ligand‐pocket interactions. The homology model Caenorhabditis elegans SDH was established, along pharmacophore After pharmacophore‐based and docking‐based screening, 19 were selected for subsequent enzymatic assays. results showed that compound 1 (ID: 7607321) exhibited inhibitory activity against...
In an effort to develop novel molecules with suitable insecticidal activities, 23,24-alkene-avermectin B2a derivatives have been synthesized via a one-pot multistep reaction using avermectin B2a, byproduct of fermentation, as starting material. All products and intermediates were characterized by 1H NMR, 13C high-resolution mass spectrometry. Bioassay results showed that the LC50 values compounds 4 9 against Meloidogyne incognita 0.63 0.50 mg/L, respectively, similar (0.46 mg/L)....
摘要 基于活性亚结构拼接法, 将双酰胺结构引入氟吡菌酰胺的骨架中, 设计并合成了 22 个含双酰胺结构的氟吡菌酰 胺衍生物.结构经过 1 H NMR、 13 C NMR 和 HRMS 鉴定, 目标化合物对 4 种植物病原真菌离体的抑制活性以及对秀丽 隐杆线虫的离体杀虫活性也进行了研究.结果显示, 在 50 mg/
The inhibition of function-specific β-N-acetyl-D–hexosaminidases, such as Of Hex1 from the Asian corn borer (Ostrinia furnacalis), is a promising strategy for development green pesticides. Among reported inhibitors, glycosyl inhibitors show especially high inhibitory activity. In this study, series novel C-glycosidic oximino carbamate derivatives were designed using OfHex1 crystal structure and synthesized. C-Glycoside studied, compound 7k exhibited best activity against (79% at 100 μM)....