A5080815780- Ovarian function and disorders
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Uterine Myomas and Treatments
- Sperm and Testicular Function
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Hypothalamic control of reproductive hormones
- Ovarian cancer diagnosis and treatment
- Bone health and osteoporosis research
- Mobile Health and mHealth Applications
- Estrogen and related hormone effects
- Phytoestrogen effects and research
- Stress Responses and Cortisol
- Menopause: Health Impacts and Treatments
- Technology Adoption and User Behaviour
- Cardiovascular Disease and Adiposity
- Hormonal and reproductive studies
- Gynecological conditions and treatments
- Adolescent Health and Behaviors
- Vitamin D Research Studies
- Pregnancy-related medical research
University of Indonesia
2016-2025
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2016-2025
HumanN (United States)
2024
Education and Research Institute
2019-2024
Indonesian Orthopaedic Association
2024
Institute of Biomedical Science
2024
Indonesian Pediatric Society
2023
Innovation Cluster (Canada)
2021
Indonesian Coral Reef Foundation
2020
Indonesian Agency for Agricultural Research and Development
2018
Oestrogens may modulate the activity of hypothalamic–pituitary–adrenal (HPA) axis. The present study was to investigate whether HPA axis in mood disorders might be directly modulated by oestrogens via oestrogen receptors (ORs) corticotropin-releasing hormone (CRH) neurons human hypothalamic paraventricular nucleus (PVN). Brains 13 subjects ranging age between 45 and 79 years suffering from major depression/major depressive disorder (eight cases) or bipolar (five controls, matched for sex,...
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20% of reproductive-age women. However, treatment PCOS mainly based on symptoms and not its pathophysiology. Neuroendocrine disturbance, as shown by an elevated LH/FSH ratio in patients, was thought to be central mechanism syndrome, especially lean PCOS. LH FSH secretion are influenced GnRH pulsatility neurons hypothalamus. Kisspeptin main regulator secretion, whereas neurokinin B (NKB) dynorphin...
To determine whether the measurement of serum AMH can be used to diagnose PCOS and as a tool predict prognosis PCOS.This is case-control study. Women reproductive age (18-35 years) were recruited consecutively at tertiary academic hospital during period March 2009-October 2011 divided into case (PCOS patients defined by Rotterdam criteria) control groups (non-PCOS patients). Menstrual history, clinical manifestations hyperandrogenism, ovarian ultrasound assessments, levels AMH, LH, FSH,...
Polycystic ovarian syndrome (PCOS) is known to be one of the most prevalent endocrine disorders affecting reproductive age women. One disorder hyperinsulinemia, which corresponds with severity PCOS. However, pathogenesis PCOS not fully understood, but theory anti-mullerian hormone (AMH) has been proposed as factor related degree there are no clear correlation between levels AMH incidence insulin resistance in patients especially Indonesia. This a cross-sectional study involving women aged...
This is the first guidelines for adenomyosis from Asian Society of Endometriosis and Adenomyosis.
To evaluate the correlation between chronological and biological age by comparing normograms of AFC, AMH, FSH.Retrospective studyData were taken from patients who visited Infertility Clinic at Dr. Cipto Mangunkusumo General Hospital Jakarta, Indonesia, January 2008 December 2010.Infertile women Clinic.None.Normogram AFC (n = 366), AMH 1616) FSH 415).The correlations among FSH, are statistically significant. Normograms with 3rd, 10th, 25th, 50th, 75th, 90th, 97th percentiles showed a decrease...
Abstract Several clinical trials in women with endometriosis demonstrated that dienogest reduces endometrial lesions and improves health-related quality of life (HRQoL). To assess HRQoL dienogest-treated patients real-world setting, we conducted a prospective, non-interventional study 6 Asian countries. Women aged ≥18 years or surgical diagnosis endometriosis, presence endometriosis-associated pelvic pain (EAPP) initiating therapy were enrolled. The primary objective was to evaluate using...
Chromosomal mosaicism, a phenomenon observed in minority of embryos, showcases its prevalence and inherent unpredictability, leading to variations embryo mosaic rates across different centers. This research endeavors assess the mosaicism characteristics within scope our preimplantation genetic testing-A (PGT-A) services Indonesia. Specifically focusing on center's experience since 2020, this study aims elucidate among embryos care. In retrospective approach, we collected secondary data...
Dienogest has been shown to substantially improve endometriosis-associated symptoms such as debilitating chronic pelvic pain, and in turn, health-related quality of life (HRQoL). To date, there is no data on patient-reported outcomes reflecting the real-world practice Asia where endometriosis a relevant health, social economic burden. This non-interventional, multi-center, prospective study aims investigate influence dienogest HRQoL. Asian women received (2 mg/daily) were followed for 24...
Sexual violence, including sexual intercourse, can occur in women experiencing vaginal discharge, particularly cases of candidiasis. In candidiasis, the microbiome undergoes changes that could serve as a diagnostic indicator or evidence activity. The aim this study was to assess effects semen insemination on profile candidiasis rats and determine its forensic investigations violence. An experimental carried out using Wistar strain (Rattus norvegicus), consisting four male (for spermatozoa...
HIGHLIGHTS Potential benefits of vitamin D3 supplementation >20 ng/ml, along with myo-inositol, folic acid, and melatonin, on implantation rates. Subsequent studies revealed no substantial enhancement in pregnancy rates when specific supplements were used. Further research is needed to provide more definitive conclusions. ABSTRACT Objective: In vitro fertilization the most common form assisted reproductive fertility technology. However, it important note success IVF generally decrease as...
The expression of estrogen receptor (ER)α and -β in the infundibular nucleus hypothalamus was studied immunocytochemically 28 control subjects 14 patients with Alzheimer's disease (AD). A shift found from more nuclear staining ERα young female controls to cytoplasmic elderly controls, whereas no such change observed male controls. cytoplasm accompanied by a relative absence AD neuropathology, i.e. hyperphosphorylated tau stained protein (AT8). In contrast, showed much stronger...
Endometriosis is a condition associated with pelvic pain, infertility, and possibly decreased quality of life as well psychiatric disorder. The purpose our study was to evaluate the association between pain characteristic, disorder, in women endometriosis.A cross-sectional done involving 160 medical diagnosis endometriosis. Pain intensity evaluated using Visual Analog Scale (VAS), Quality Life Health Profile (EHP-30), psychologic Mini International Neuropsychiatric Interview Classification...
Abstract Background The purpose of this research was to investigate whether high AMH levels in PCOS patients resulted different IVF outcomes compared those non-PCOS patients. Methods A retrospective cohort study conducted involving 238 women undergoing who had > 4 ng/ml. Participants were divided into two groups: and non-PCOS. Results median level significantly higher the group (7.59 ± 4.61 ng/ml vs. 5.91 2.22 ng/ml, p < 0.001). required less gonadotropin but yielded more oocytes after...
Endometriosis is identified as presence of the endometrium outside uterine cavity. Retrograde menstruation contributes to endometrial tissue implantation and establishment endometriotic lesions at ectopic sites. It has been suggested that are rich in angiogenic growth factors, while they have an essential role survival invasion these cells. We investigated regulation microRNA-93 (miR-93) its involvement with vascular endothelial factor A (VEGFA) matrix metalloproteinase (MMP) 3 expression...
This study aimed to evaluate sperm chromatin maturity and integrity of that injected into good-quality oocytes in an vitro fertilization-intra cytoplasmic injection (IVF-ICSI) program. A cut-off value was developed as a function their correlation the zygote development, i.e., embryo formation cleavage rate. The assessed using aniline blue (AB) staining, whereas toluidine (TB) staining used assess integrity. Ejaculates from 59 patients undergoing ICSI 46 fertile normozoospermic donors for...
To determine the role of anthropometric measurement, menopausal symptoms and biochemical marker changes as screening methods for mild cognitive impairment (MCI) in postmenopausal women Methods: A cross-sectional study included 282 Jakarta, further classified into two groups, with without MCI. Some related variables such age, body mass index (BMI), duration menopause, vasomotor symptoms, hormone levels follicle stimulating (FSH), luteinizing hormone, leptin, estradiol, status, were assessed...
Polycystic ovary syndrome (PCOS) is an endocrinopathic disorder most commonly experienced by women of reproductive age, and it characterized a low-grade chronic inflammatory condition. Excessive fat deposit has been long considered as etiological factor in the pathogenesis this Currently, body mass index (BMI) or percentage used marker to assess composition person.To determine whether BMI (BFP) can be better for measuring inflammation related accumulation polycystic patients.This study took...
Background: Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% worldwide. Hyperandrogenism, as primary characteristic PCOS, not always present every patient. The hyperandrogenic phenotype PCOS patients influenced by both hormonal and metabolic dysfunctions. Therefore, this study aims to determine correlation between hormone profile, lipid clinical profile with free testosterone index subjects PCOS. Methods: This prospective...