A5087661912- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Childhood Cancer Survivors' Quality of Life
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Lymphatic System and Diseases
- Neonatal Respiratory Health Research
- Spinal Dysraphism and Malformations
- Neuroscience of respiration and sleep
Monash University
2022-2024
Background: Fluids, solutes and immune cells have been demonstrated to drain from the brain surrounding structures cervical lymph vessels nodes in neck via meningeal lymphatics, nasal lymphatics and/or lymphatic associated with cranial nerves. A method cannulate efferent duct for continuous fluid collection rodents has not described previously would assist evaluating transport of molecules head as well changes composition different physiological challenges or diseases. Aim: To develop a...
In recent years, the drainage of fluids, immune cells, antigens, fluorescent tracers, and other solutes from brain has been demonstrated to occur along lymphatic outflow pathways deep cervical lymph nodes in neck. To best our knowledge, no studies have evaluated transport therapeutics brain. The objective this study was determine model different molecular weights lipophilicity using cannulation ligation models rats. do this, anesthetized Sprague–Dawley rats were cannulated at carotid artery...
The drainage of fluid and solutes along lymphatic pathways from the brain has been found to be impaired in mouse models multiple sclerosis, Alzheimer's disease, Parkinson's disease where neuroinflammation is present. We recently demonstrated that 3H-albumin, a model therapeutic protein (∼65 kDa), undergoes preferential transport using cervical lymph cannulation healthy rats. thus hypothesized would impede 3H-albumin brain. Our aim was quantify impact acute on (3H-albumin) rat into blood deep...