A5017570333- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Lymphatic System and Diseases
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Advanced Drug Delivery Systems
- Anesthesia and Neurotoxicity Research
- Streptococcal Infections and Treatments
- Advancements in Transdermal Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Nursing Diagnosis and Documentation
- Toxin Mechanisms and Immunotoxins
- Sphingolipid Metabolism and Signaling
- RNA Interference and Gene Delivery
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Pleural and Pulmonary Diseases
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Cystic Fibrosis Research Advances
Monash University
2020-2024
Cairo University
2023
The University of Texas Medical Branch at Galveston
2021
King Saud Medical City
2015-2020
Mid Essex Hospital Services NHS Trust
2019
Many sedation scales and tools have been developed compared for validity in critically ill patients. However, selection use of vary among intensive care units.The aim this study is to compare the reliability 2 scales-Ramsay Sedation Scale Richmond Agitation-Sedation (RASS)-in adult unit.Four hundred twenty-five patients were recruited study. Informed consent had obtained from each patient guardian/relative. only 290 (68.24%) completed independently assessed effect by investigator bedside...
Rates of carbapenem-resistant Pseudomonas aeruginosa are increasing. Aggressive prevention strategies, including instituting antimicrobial stewardship programmes, essential for combating resistance.We conducted this study to compare the susceptibility pattern P. before and after carbapenem restriction.We a two-phase retrospective in an adult ICU. The first phase was from May until July 2016 (before restriction), whereas second September November (while implementing restriction). reviewed...
Delivery to peripheral lymphatics can be achieved following interstitial administration of nano-sized delivery systems (nanoparticles, liposomes, dendrimers etc) or molecules that hitchhike on endogenous carriers (such as albumin). The published work concerning the hitchhiking approach has mostly focussed lymphatic uptake vaccines conjugated directly albumin binding moieties (ABMs such lipids, Evans blue dye derivatives peptides) and their subsequent trafficking into draining lymph nodes....
Peptides, despite their therapeutic potential, face challenges with undesirable pharmacokinetic (PK) properties and biodistribution, including poor oral absorption cellular uptake, short plasma elimination half-lives. Lipidation of peptides is a common strategy to improve physicochemical PK properties, making them viable drug candidates. For example, the half-life has been extended via conjugation lipids that are proposed promote binding serum albumin thus protect against rapid clearance....
Polymeric prodrugs have been applied to control the delivery of various types therapeutics. Similarly, conjugation peptide therapeutics lipids has used prolong systemic exposure. Here, we extend on these two approaches by conjugating brush polyethylene glycol (PEG) polymers with different lipid components including short-chain (1C2) or medium-chain (1C12) monoalkyl hydrocarbon tails, cholesterol (Cho), and diacylglycerols composed (2C12) long-chain (2C18) fatty acids. We uniquely evaluate...
We present the case of 31-year-old man who developed hospital-acquired pneumonia in intensive care unit. Pathogens were identified to be carbapenem-resistant isolates Providencia stuartii and Klebsiella pneumoniae. The patient was treated with an extended infusion double-dose meropenem (targeting P. stuartii) colistin K. pneumoniae) for 2 weeks. patient's disease responded well prescribed regimen; his chest X-ray became normal, all other signs infection subsided. To our knowledge, this is...
Background: Delirium in intensive care units (ICUs) is associated with long ICU stay, hospital stay and increased costs of treatment. Unfortunately, delirium significantly underestimated overlooked by healthcare providers. Aims: The aim this tudy to determine the incidence risk factors among critically ill patients Saudi Arabia. Methods: This a prospective study. Patients were assessed for using confusion assessment method ICU. was independent variable Results: Fifty-nine (17.3%) showed...
Background: Many sedation scales and tools have been developed compared for validity in critically ill patients. Objective: The aim of this study is to compare the reliability two scales; RAMSAY scale Richmond Agitation Sedation Scale (RASS) adult intensive care unit. Methods: 290 patients unit were recruited independently assessed effect by investigator bedside nurses simultaneously using RASS scale. Results: Agreement between nurse researcher scores on (weighted κ=0.449, p<0.001)...
Background: One of the most common medications, that their ordering is associated with many medication errors, PRN medications. In order to explore types errors are and test correlation between these factors, we conducted this study. Methods: A comparative cross-sectional study design was used, all medical records for critically ill patients were screened medications orders. All occurred in stage process documented. The March 2015. Results: 114 found on order. Among those patients, 130...
We conducted a two-phase retrospective study to investigate the impact of short-term carbapenem restriction on incidence non-pseudomonal multidrug-resistant (MDR) Gram-negative bacilli in our intensive care unit (ICU). The first phase (before restriction) was between May and July 2016, second (implementation September November 2016. all MDR (extended-spectrum β-lactamase-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae Acinetobacter baumannii) decreased significantly...
Changes to the number, type, and function of immune cells within joint-draining lymphatics is a major contributor progression inflammatory arthritis. In particular, there significant expansion in pathogenic B lymph node (jdLN). These appear clog lymphatic sinuses node, inhibit flow, therefore, reduce clearance fluid from joint. Taken together, potential treat arthritis more effectively, as well off-target side effects, with localized delivery B-cell depleting therapies jdLNs. We recently...
Abstract Objectives To evaluate echocardiographic parameters, especially the Tei index as a predictor of outcome in critically ill children on continuous renal replacement therapy (CRRT). Methods This cohort study included all patients admitted at Pediatric intensive care unit (PICU) and underwent CRRT. Functional echocardiography Risk Mortality Index (PRISM) III were used to participants. Both Vasoactive inotropic score (VIS) estimated. Results The 35 with an age range 6 mo 14 y. indexes,...
Corticosteroids are one of the most common medications that used in intensive care units (ICUs); corticosteroids for a variety indications, including septic shock, acute respiratory distress syndrome (ARDS), bacterial meningitis, tuberculous lupus nephritis, severe chronic obstructive pulmonary disease (COPD) exacerbations and many others.Corticosteroids associated with side effects affect morbidity mortality patients like increased risk infections, glucose intolerance, hypokalemia, sodium...
Background: Infective endocarditis remains a major cause of morbidity and mortality worldwide. There are concerns related to the increased number infections associatedwith virulent agents medical procedures. Objective: The aim this study was reveiw surgical experience in cardiothoracic department, National Heart Institute (NHI) regarding patients with native or prosthetic valve determining predictors mortality. Patients Methods: A prospective fifty consecutive diagnosed definite infective...