A5101719893- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- Advanced Proteomics Techniques and Applications
- Immune cells in cancer
- Genomics and Phylogenetic Studies
- Immune Response and Inflammation
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- CAR-T cell therapy research
- Dermatologic Treatments and Research
- Coastal wetland ecosystem dynamics
- Environmental Impact and Sustainability
- Land Use and Ecosystem Services
- Marine animal studies overview
- Marine and coastal plant biology
- Coastal and Marine Dynamics
- Single-cell and spatial transcriptomics
- Historical, Literary, and Cultural Studies
- Facial Nerve Paralysis Treatment and Research
- Microgrid Control and Optimization
- Cell Image Analysis Techniques
- Glycosylation and Glycoproteins Research
- Congenital Diaphragmatic Hernia Studies
- Forest Management and Policy
- Atherosclerosis and Cardiovascular Diseases
The Francis Crick Institute
2025
Duke University
2024
University of Edinburgh
2020-2022
Wellcome Centre for Cell Biology
2020-2022
University of Wisconsin–Madison
2011
Harvard University
2009
Ipswich Hospital
2006
UCLA Medical Center
1994-2001
Harbor–UCLA Medical Center
1994-2001
Northgate Hospital
1935
Abstract Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, often neglected. In present study, we have shown that ARDS patients were hypoxemic monocytopenic within first 48 h ventilation. Monocytopenia was also observed in mouse models hypoxic lung injury, which hypoxemia drove suppression type I interferon signaling bone marrow....
There are more than 15,000 barrier islands in fetch-limited nearshore environments around the world. About half that number actively evolving (eroding, accreting, migrating) response to oceanographic processes and subject of this study. The remaining consists inactive protected by surrounding salt marsh or mangroves. Despite their global abundance these have not been previously systematically studied even recognized as a major landform type. More 70% found on trailing edge coasts because...
Signaling from the T cell antigen receptor (TCR) on CD4+ cells plays a critical role in adaptive immune responses by inducing activation, proliferation, and differentiation. Here we demonstrate that WNK1, kinase implicated osmoregulation kidney, is required to support T-dependent antibody responses. We show canonical WNK1-OXSR1-STK39 signaling pathway for TCR cells, their subsequent entry into cycle, suppression of ATR-mediated G2/M cycle checkpoint. WNK1 regulates ion influx leading water...
Rapid proliferation and expansion of cytotoxic CD8 T lymphocytes is crucial for adaptive immunity against viral infection. cell cycles complete division in <6 hours, representing a physiological extreme somatic mammalian cells. Embryonic stem cells also rapidly divide have been shown to utilize specialized cycle control mechanisms that differ from fibroblasts, including subdued periodicity cyclin proteins. remains poorly understood compared embryonic other types. Here, we tested whether...
Lewis, D.A., Cooper, J.A.G., Pilkey, O.H., and Short, A.D 2007. Fetch-limited barrier islands of Spencer Gulf, South Australia. Journal Coastal Research, SI 50 (Proceedings the 9th International Symposium), 912 – 916. Gold Coast, Australia, ISSN 0749-0208 Islands that form in fetch-limited coastal environments are widely distributed but poorly documented seldom recognised as a distinctive landform type. They occur variety sheltered worldwide. In upper Australia abundant (numbering around...
Comprehensive proteome analysis of rare cell phenotypes remains a significant challenge. We report method for low number MS-based proteomics using protease digestion mildly formaldehyde-fixed cells in cellulo, which we call the "in-cell digest." combined this with averaged MS1 precursor library matching to quantitatively characterize proteomes from numbers human lymphoblasts. About 4500 proteins were detected 2000 cells, and 2500 quantitated 200 The ease sample processing high sensitivity...
Abstract Signaling from the T cell antigen receptor (TCR) on CD4 + cells plays a critical role in adaptive immune responses by inducing activation, proliferation, and differentiation. We demonstrate that WNK1, kinase implicated osmoregulation kidney, is required to support T-dependent antibody responses. WNK1-deficient are severely impaired their ability proliferate generate antigen-specific follicular helper response immunization with antigen. show WNK1 its downstream OXSR1 STK39 kinases...
Lamellar body count (LBC) in amniotic fluid is a well-established method for assessing fetal lung maturity. However, the biogenesis and function of lamellar bodies (LBs) secreted into have not been formally assessed. We purified LBs from fluids obtained term gestation pregnancies that had determined to mature LBC. Using tandem mass spectrometry, we identified 122 unique proteins LB preparations fluids. There was minimal overlap between those reported human epidermis LB. In contrast, there...
In many countries the existence of a comprehensive approach to environmental control through auspices unified agency is accepted. United States, for instance, creation Environmental Protection Agency (EPA) has received substantial support. Allen Kneese remarked that “while anyone who observed Washington scene any period time just cause be skeptical efficiency reorganisation, one can still recognise convincing rationale this one”. Kingdom rather ageing and as yet unacted‐upon report Royal...
Severe, acute exacerbations of chronic obstructive pulmonary disease are a common presentation to emergency departments in the UK. In this group patients, clinical examination can be unreliable excluding pneumothorax. With increasing role non-invasive positive pressure ventilation these cases, we present case report that highlights need for an urgent chest X-ray prior commencement ventilation.