A5003328506- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Pharmacovigilance and Adverse Drug Reactions
- Blood groups and transfusion
- Ethics and Legal Issues in Pediatric Healthcare
- Hepatitis B Virus Studies
- Central Venous Catheters and Hemodialysis
- Renal Transplantation Outcomes and Treatments
- Prenatal Screening and Diagnostics
- Poisoning and overdose treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Child and Adolescent Health
- Sex work and related issues
- COVID-19 and Mental Health
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Long-Term Effects of COVID-19
- Metabolism and Genetic Disorders
- Infant Development and Preterm Care
- Kawasaki Disease and Coronary Complications
- Immunodeficiency and Autoimmune Disorders
- Preterm Birth and Chorioamnionitis
- Erythrocyte Function and Pathophysiology
Mahatma Gandhi University
2022-2023
Gandhi Medical College & Hospital
2023
Mahatma Gandhi Institute of Medical Sciences
2022
University of Medical Sciences and Technology
2021
Borlaug Institute for South Asia
2013-2020
East Asia Institute
2014
Jagriti Innovations developed a collaboration tool in partnership with the Cure2Children Foundation that has been used by health professionals Italy, Pakistan, and India for collaborative management of patients undergoing bone marrow transplantation (BMT) thalassemia major since August 2008. This online open-access database covers data recording, analyzing, reporting besides enabling knowledge exchange, telemedicine, capacity building, quality assurance. As February 2014, over 2400 have...
Matched-related bone marrow transplantation (BMT) may cure >80% of low-risk children with severe thalassemia (ST). Very long-term follow-up studies have shown how the standard busulfan-cyclophosphamide (BuCy) regimen be associated normalization health-related quality life, no second malignancies in absence chronic graft-versus-host disease, and fertility preservation many patients. However, because BuCy high rejection rates, some centers incorporate thiotepa (Tt) busulfan- or...
Thalassemias are the most common inherited genetic disorder in India and a major public health burden with bone marrow transplant (BMT) considered only established curative therapy. We describe outcomes for patients (n = 71) standard-risk thalassemia (liver size < 2 cm age <15 years), receiving BMT 6 low-cost start up centers Indian sub-continent from August-2013 to July-2016. Patients received HLA-matched sibling donor unmanipulated BMT. Conditioning was busulfan (14 mg/kg oral total over...
Rejection of paternal vs maternal fully matched bone marrow grafts in children with thalassemia
Severe thalassemia syndromes (ST) are highly curable by bone marrow transplant (BMT), but rejection may still occur. We retrospectively analyzed our fully matched related donor transplants to establish if isolated splenomegaly is an independent risk factor for and this can be reduced modifying the conditioning protocol. In study, we compared rates between patients with without in 189 consecutive low-risk ST across 2 sequential regimens: regimen A (August 2013 December 2016): busulfan (14...
Even though severe thalassemia is a preventable disease, over 100,000 new cases are born yearly, particularly in the Middle East and South-East Asia. Most of these children may not reach adulthood because long-term appropriate supportive care either inaccessible or unaffordable. Bone marrow transplantation (BMT) remains only available definitive cure success rates can be very high appropriately selected patients, i.e. low-risk younger with matched family donor. In circumstances BMT justified...
Abstract Background Patients with tunneled central venous lines (CVL) may develop bloodstream infections which at times are difficult to control without line removal. Concomitant severe thrombocytopenia platelet transfusion refractoriness is often considered a major contraindication any procedure involving blood vessel. There very little literature on the clinical risks of removal in febrile pancytopenia patients. Procedure We analyzed complications and outcomes all our patients, total 52,...
The present study has been carried out to determine the risk factors associated with recurrent febrile seizures. Thestudy was a hospital based prospective observational study. Risk of evaluated on basis cumulative analysis clinical profile all cases. Every child followed up for one year. In our recurrence seen in 34 (55.7%) subjects. Factors like age less than 1 year at first episode seizure, fever duration &#60;24 hours and temperature time seizure &#60; 102.2F had higher...
Objective: Coronavirus disease-19 (COVID-19) infection has quickly developed into a global pandemic. According to the available evidence, children appear be less likely afflicted and condition may severe, but things could change. Rapid deterioration enhancements in physiologic state are hallmark of pediatric community. Therefore, this study was conducted with aim demographic clinical parameters COVID patients. Methods: This hospital-based prospective retrospective during April 1st, 2020–July...
Purpose: Auto immune hemolyticanemia (AIHA) post allogeneic hematopoetic stem cell transplantation (HSCT) is a rare and still poorly understood complication.Detailed work on this complication are needed due to lack of prospective trials.Methods: This retrospective cohort study 7 patients with AIHA after HSCT in tertiary care Medical College Hospital from 2012 -2023.Results: The overall incidence was 3.93%.All transplants were performed for non -malignant condition.57.1 % the who developed...
BackgroundSevere thalassemia syndromes (ST) are highly curable by BMT but rejection may occur in 5 to 30% of cases. Splenomegaly was shown increase the risk even low transplant setting our earlier review (https://ash.confex.com/ash/2017/webprogram/Paper104001.html).ObjectiveTo assess impact splenomegaly on and study effectiveness increased immunosuppression preparative regimen.MethodsWe compared outcomes patients with between two conditioning regimens: Our protocol (Regimen A) a more recent...