A5071367022- Pharmacological Effects of Natural Compounds
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Heart Rate Variability and Autonomic Control
- Synthesis and biological activity
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Bioactive Compounds and Antitumor Agents
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Neurotransmitter Receptor Influence on Behavior
- Ginkgo biloba and Cashew Applications
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Pharmacogenetics and Drug Metabolism
- Phytochemicals and Antioxidant Activities
- Medicinal Plant Extracts Effects
- Medicinal Plants and Neuroprotection
- Natural product bioactivities and synthesis
- Alkaloids: synthesis and pharmacology
- Biochemical Analysis and Sensing Techniques
- Sports Performance and Training
- Synthesis and Biological Evaluation
- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
Universidade Federal de Goiás
2016-2025
Universidade Evangelica de Goiás
2018-2025
Universidade Estadual de Goiás
2023-2024
University of Mississippi
2018
Department of Physiological Sciences
2014
Spiranthera odoratissima A. St. Hil. (manacá) is used in folk medicine to treat renal and hepatic diseases, stomachache, headaches rheumatism. A central nervous system (CNS) depressant effect of the hexane fraction from ethanolic extract this plant has been described. β-caryophyllene, main component essential oil, a sesquiterpene compound with anti-inflammatory properties that found oils derived several medicinal plants. This work aimed evaluate pharmacological activity oil obtained S....
Objective: To evaluate the affective responses to running with imposed velocity or self-selected time trials in runners, as well effects on volume load (VL) and training impulse (TRIMP). Anxiety was also determined. We established level of association between dependent variables. Methods: Three visits were carried out. The 1st visit consisted a maximum effort test (VO2Max). In 2nd 3rd visits, participants divided limit (TLim) trial 1000 m at intensity (T1000). Participants responded felt...
Our study sought to evaluate the anxiolytic and antidepressant activities of oleanolic acid as well neural mechanisms involved. Animal models such barbiturate sleep-induction, light–dark box, elevated plus maze, forced swimming test, tail suspension test open field were conducted. Male Albino Swiss mice treated orally with vehicle 10 mL/kg, fluoxetine 20 mg/kg, imipramine 15 diazepam 1 mg/kg or 5–40 mg/kg. Pretreatment (intraperitoneal) animals pentylenetetrazole (PTZ)...
To establish the capacity of absolute maximum strength and relative to body mass (BM) in deadlift (DL) squat (SQ) exercises estimate anaerobic running performance (MART) aerobic power (VPeak), among individuals stratified into high (HS) vs. low score (LS). The sum workloads (DL+SQ) was also analyzed cross-validation tested. Thirty-four students performed five visits first phase. In three following were performed: sample characterization consistency analysis repetition (RM) for DL SQ....
Climate change and environmental security are ongoing challenges in Nigeria. This literature review explores the dynamics of climate alongside proposed solutions. The study employs qualitative research, primarily drawing on reports from international NGOs that address ecological It also utilizes content analysis based literature, additional bibliographies, published academic works. results indicate issue Nigeria still requires further exploration, as no provide in-depth investigations....
The cardiorespiratory optimal point (COP) is an emerging submaximal parameter from cardiopulmonary exercise testing (CPET) that reflects the balance between cardiac workload and pulmonary ventilation. Recent studies have explored clinical utility prognostic value of COP in various populations, particularly patients with heart failure (HF). This comprehensive literature review evaluated current evidence on its potential as independent risk factor for cardiovascular disease mortality. has been...
Caffeine (CAF) and transcranial direct current stimulation (tDCS) are ergogenic strategies with potential benefits for performance, yet their combined effects remain underexplored, particularly in high-intensity functional training contexts such as CrossFit®. This randomized, double-blind, placebo-controlled crossover study aimed to investigate the impact of tDCS, without CAF, on performance time Clean & Jerk (C&J) during benchmark WOD GRACE among competitive CrossFit® athletes. Secondarily,...
ABSTRACT A simple and selective high‐performance liquid chromatography bioanalytical method was developed validated to determine the pharmacokinetic parameters of 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole (LQFM020) with promising vasorelaxant, anti‐inflammatory, antinociceptive properties while verifying its potential hepatic enzyme induction or inhibition. Chromatographic separation achieved using a reversed‐phase C18 column (ACE, 150 × 4.6 mm, 5 μm) isocratic elution solvent...
This work provides insight into carbamazepine polymorphs (Forms I, II, III, IV, and V), with reports on the cytoprotective, exploratory, motor, CNS-depressant, anticonvulsant properties of (CBZ), formulation (CBZ-F), topiramate (TOP), oxcarbazepine (OXC), diazepam (DZP) in mice. Structural analysis highlighted significant difference molecular conformations, which directly influence physicochemical properties; density functional theory description provided indications about CBZ reactivity...