A5018106262- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Osteoarthritis Treatment and Mechanisms
- Obesity, Physical Activity, Diet
- Acute Myocardial Infarction Research
- Electrolyte and hormonal disorders
- Thermoregulation and physiological responses
- Cardiac Imaging and Diagnostics
- Occupational Health and Performance
- Knee injuries and reconstruction techniques
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sports injuries and prevention
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Physical Activity and Health
- Nutrition and Health in Aging
- Congenital Heart Disease Studies
- Magnetic confinement fusion research
- Children's Physical and Motor Development
- Dietary Effects on Health
- Musculoskeletal pain and rehabilitation
Lund University
2014-2025
Skåne University Hospital
2019-2025
Malmö University
2024
Linköping University Hospital
2023
Harvard University
2017-2018
Lemuel Shattuck Hospital
2018
Brigham and Women's Hospital
2016-2018
To evaluate whether history of pregnancy complications [pre-eclampsia, gestational hypertension, preterm delivery, or small for age (SGA)] improves risk prediction cardiovascular disease (CVD). This population-based, prospective cohort study linked data from the HUNT Study, Medical Birth Registry Norway, validated hospital records, and Norwegian Cause Death Registry. Using an established CVD model (NORRISK 2), we predicted 10-year (non-fatal myocardial infarction, fatal coronary heart...
Ischemic heart disease and stroke are two severe types of cardiovascular (CVD), a major contributor to the global burden disease. The preventive framework currently includes promotion both adequate cardiorespiratory muscular fitness. Although muscle fitness is established as an indicator health, it unknown whether strength associated with later CVD independently fitness.We studied 38,588 Swedish men who in 1969 1970 (typically aged 18 years) completed compulsory conscription. Using mean...
Objectives To study the association between lifestyle risk factors and chronic hypertension by history of hypertensive disorders pregnancy (HDP: gestational pre-eclampsia) investigate extent to which these modify HDP hypertension.Design Prospective cohort study.Setting Nurses' Health Study II (1991-2013).Participants 54 588 parous women aged 32 59 years with data on reproductive without previous hypertension, stroke, or myocardial infarction.Main outcome measure Chronic diagnosed a physician...
Background Fetal exposure to preeclampsia is associated with higher blood pressure and later risk of stroke. We aimed investigate the associations maternal preeclampsia, gestational hypertension, change in pregnancy offspring cardiac structure function adolescence. Methods Results Using data from a prospective birth cohort study, we included who underwent echocardiography (mean age, 17.7 years; SD , 0.3; N=1592). examined whether hypertensive disorders were systolic/diastolic using linear...
Importance Adverse pregnancy outcomes are recognized risk enhancers for cardiovascular disease, but the prevalence of subclinical coronary atherosclerosis after these conditions is unknown. Objective To assess associations between history adverse and artery disease assessed by computed tomography angiography screening. Design, Setting, Participants Cross-sectional study a population-based cohort women in Sweden (n = 10 528) with 1 or more deliveries 1973 later, ascertained via Swedish...
Women with a history of hypertensive disorders pregnancy (HDP; preeclampsia and gestational hypertension) or delivering low birth weight offspring (LBW; < 2500 g) have twice the risk cardiovascular disease (CVD). We aimed to study extent which these complications improves CVD prediction above beyond conventional predictors. Parous women attended standardized clinical visits in Sweden. Data were linked registries deliveries CVD. Participants followed for first event within 10 years from age...
Background Cardiovascular, respiratory, and musculoskeletal disease are among the leading causes of disability in middle-aged older people. Health lifestyle factors youth have known associations with cardiovascular or respiratory adulthood, but largely unknown disease. Methods findings We included approximately 40,000 18-year-old Swedish males, who completed their conscription examination 1969 to 1970, followed up until age 60 years. Exposures interest were physical health: body mass height,...
Heart failure (HF) is a common disease with increasing prevalence and poor prognosis. The vasopressin (VP) marker copeptin predicts development of diabetes mellitus, diabetic heart disease, coronary artery premature mortality. Copeptin elevated in HF patients worse outcome. This study aims to investigate whether can predict development.Copeptin was analysed 5297 individuals (69.6% men) without prevalent from the Malmö Preventive Project, population-based prospective cohort. Cox proportional...
Women with history of hypertensive disorders pregnancy (HDP) are at increased risk early onset cardiovascular disease and type 2 diabetes (T2D). We aimed to investigate the extent which HDP is also associated midlife development T2D hypertension above beyond established factors.We included parous women who attended population-based structured clinical visits age 50 60 years in Sweden 1991-2013 (N = 6587). prior mellitus, stroke, or ischemic heart were excluded. Data on reproductive collected...
Abstract Vasopressin is a pleiotropic hormone that controls body fluid homeostasis. has also been proposed to be involved in erythropoiesis, thrombocyte activity and inflammation. However, whether increasing vasopressin associated with changes hematopoietic markers not known. To evaluate this gap of knowledge we measured the marker copeptin erythropoiesis (erythrocyte count, hemoglobin (Hb), red blood cell distribution width (RDW), mean corpuscular volume (MCV), erythrocyte fraction (EVF)),...
<h3>Objectives</h3> To assess the extent to which knee extensor strength and weight in adolescence are associated with osteoarthritis (OA) by middle age. <h3>Methods</h3> We studied a cohort of 40 121 men who at age 18 years 1969/1970 underwent mandatory conscription Sweden. retrieved data on isometric strength, weight, height, smoking, alcohol consumption, parental education adult occupation from Swedish registries. identified participants diagnosed OA or injury 1987 2010 through National...
Women with a history of hypertensive disorders pregnancy (HDP) are at increased risk hypertension, cardiovascular disease, and type 2 diabetes. Offspring from pregnancies complicated by HDP also have worse cardiometabolic status in childhood young adulthood, but the offspring clinical hypertension adulthood is largely unknown. We studied 13,893 first-born adult (49.4% female) who attended structured population-based primary care visit (The Västerbotten Health Survey) age 40 years Sweden...
We aimed to determine the relationship between handgrip strength, smoking, and alcohol consumption in young men fracture risk at middle age. Thus, we carried out a cohort study including undergoing conscription examination Sweden from September 1969 May 1970 typical age of 18 years. Data on muscle height, weight, lifestyle factors were linked National Patient Register 1987-2010. Handgrip strength was considered main exposure smoking as secondary exposures. Outcomes all fractures (except...
Musculoskeletal pain is highly prevalent throughout adulthood with a major impact on health, function and participation in the society. Still, association between muscle strength development of musculoskeletal unclear. We aimed to study whether overall adolescent men inversely associated self-reported adulthood.Cohort baseline data from Swedish Conscription Register outcome information random population-based Living Conditions Surveys.Sweden, 1970-2005.5489 who at age 17-19 years tested...
Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake. also a causal candidate for cardiometabolic disease, which shows seasonal variation.
Women with a history of adverse pregnancy outcomes have higher risk coronary heart disease. Emerging evidence suggests that women preeclampsia different pattern overall atherosclerosis and they at the time myocardial infarction (MI) more frequently present ST-segment elevation MI (STEMI) compared to no such history.
ABSTRACT Objective Maternal hemodynamics in pregnancy is associated with fetal growth and birth weight, which turn are offspring cardiovascular disease later life. The aim of this study was to quantify the extent weight cardiac structure function adolescence. Methods A subset ( n = 1964; 55% female) Avon Longitudinal Study Parents Children were examined echocardiography at a mean age 17.7 (SD, 0.3) years. associations birth‐weight Z ‐score for sex gestational (assessed by relative wall...
Objective To simplify the previously published Nottingham 12‐year risk prediction model for knee osteoarthritis ( OA ) and examine whether it can be used to predict 40‐year of in young men. Methods Our cohort included 40,118 men who were 18 years age had undergone military conscription Sweden from 1969 1970. Diagnostic codes obtained Swedish National Patient Register persons registered 1987 2010. The original as predictors age, sex, body mass index BMI ), injury, occupational risk, family...
We hypothesized that a low grade in physical education (PE) is associated with an increased risk of future musculoskeletal conditions, especially chronic pain. Using historical cohort study design, we identified all students (mean age 16.0 years), who 1974-1976 graduated from compulsory school Swedish municipality and retrieved their PE grades. ensured persons were still alive resident the county 2003-2007 linked data to Skåne Health Care Register covering in- outpatient care county....
OBJECTIVE To study the extent to which BMI after pregnancy adds elevated risk of postpregnancy type 2 diabetes in women with a history hypertensive disorders (HDP) (preeclampsia or gestational hypertension). RESEARCH DESIGN AND METHODS We used data from Nurses’ Health Study II, prospective cohort study. In aged 45–54 years without prior mellitus, we investigated interaction between and HDP on diabetes. For clinical public health relevance, focused additive interaction. The main outcome...
Studies suggest preeclampsia as a risk factor for long term cardiovascular diseases (CVD), while evidence is limited regarding the of high blood pressures (BP) in early pregnancy. A register-based follow-up 2434 mothers Helsingborg Birth Cohort. Associations BP pregnancy (>95th percentile systolic [SBP], diastolic [BDP], or mean arterial [MAP]) during first antenatal visit and/or with an incident CVD event (ischemic heart disease stroke) were assessed. To model risks and adjust co-variables,...
Women are at a greater risk of major adverse cardiovascular event (MACE) after percutaneous coronary intervention than men. A history preterm delivery is female-specific factor for artery disease, but its relevance in the treatment disease unknown. The purpose this study was to analyze association between and MACE first stenting. We included nationwide sample 5,766 Swedish women aged ≤65 years receiving their stent during 2006 2017. To adjust periprocedural characteristics estimate >30 days...
(Abstracted from BMJ 2017;358:j3024) Hypertensive disorders of pregnancy (HDPs: preeclampsia and gestational hypertension) are associated with earlier onset chronic hypertension a higher risk ischemic heart disease stroke affect between 5% 10% parous women. There is little guidance for the prevention among women history HDPs, role lifestyle in progression HDPs to unclear, including whether established interventions as effective general population.