A5103086595- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Drug Transport and Resistance Mechanisms
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer, Hypoxia, and Metabolism
- Pharmacological Receptor Mechanisms and Effects
- Computational Drug Discovery Methods
- Cancer-related gene regulation
- Cancer therapeutics and mechanisms
- Microbial infections and disease research
- Synthesis and biological activity
- CRISPR and Genetic Engineering
- Gut microbiota and health
- Fluorine in Organic Chemistry
- Receptor Mechanisms and Signaling
- Antimicrobial Resistance in Staphylococcus
- Synthetic Organic Chemistry Methods
- Cholesterol and Lipid Metabolism
- Asymmetric Synthesis and Catalysis
- Biliary and Gastrointestinal Fistulas
- Plant Pathogenic Bacteria Studies
Suzhou Nonferrous Metals Research Institute
2025
First Affiliated Hospital of Gannan Medical University
2025
Pfizer (United States)
2010-2024
ENN (China)
2024
South China Agricultural University
2021-2023
Key Laboratory of Guangdong Province
2021-2022
Harbin Medical University
2022
Second Affiliated Hospital of Harbin Medical University
2022
University of California, Berkeley
2015-2021
Henan University
2021
Pasteurella multocida (P. multocida) is an important pathogenic bacterium that poses a serious threat to the development of livestock economy and human health. Currently, existing methods for P. detection are time-consuming require complex professional operations, limiting application field detection. In study, we presented single-pot naked-eye CRISPR-Cas12a platform (Cas12a-NEye) multocida. The round tube cover allowed more Cas12a solution be temporarily stored than flat cap, enabling...
The chicken gut microbiota, as a reservoir of antibiotic resistance genes (ARGs), poses high risk to humans and animals worldwide. Yet comprehensive exploration the resistomes remains incomplete. In this study, we established largest gene catalogue date through metagenomic analysis 629 samples. We found significantly higher abundance ARGs in Chinese than that Europe. tetX, mcr, blaNDM, resistant antibiotics last resort for human animal health, were detected gut. was linearly correlated with...
Abstract The intimate relationship between humans and companion animals causes a unique critical aspect of antimicrobial resistance in humans. However, comprehensive analysis their owners is lacking. Here, we chose 13 owned dogs 16 as well 22 kennel to analyze the effect an on gut microbiome, antibiotic genes (ARGs), mobile genetic elements (MGEs) study correlation families by metagenomics. Dog microbiota had higher abundance diversity ARGs while taxonomy. In dog microbial community, ARG MGE...
With the tremendous success of large language models such as ChatGPT, artificial intelligence has entered a new era models. Multimodal data, which can comprehensively perceive and recognize physical world, become an essential path towards general intelligence. However, multimodal trained on public datasets often underperform in specific industrial domains. In this paper, we tackle problem building vision-language intelligent for domains by leveraging federated learning. We compare challenges...
Zinc-ion batteries (ZIBs) are an ideal choice for large-scale energy storage due to their high safety, environmental friendliness, and low cost. However, performance is constrained by challenges related cathode materials, such as poor conductivity, dissolution of active structural instability during cycling. In this study, α-MnO2 material with a tunnel structure was synthesized via hydrothermal method, MnSO4 introduced into the ZnSO4 electrolyte optimize electrochemical ZIBs....
Long noncoding RNAs (lncRNAs) have emerged to irreplaceable roles in the epigenetic regulation of cancer progression, but their biological functions colorectal (CRC) remain unclear.LncRNA expression profiles CRC tissue and normal counterpart were explored. Through gain loss function approaches, role lncRNA PTTG3P was validated relevant cells subcutaneous tumor model. The correlations with clinical outcomes assessed.PTTG3P upregulated tissues closely correlated unsatisfactory prognosis....
Long noncoding RNAs (lncRNAs) play critical factors in tumor progression and are ectopically expressed malignant tumors. Until now, lncRNA pituitary tumor-transforming 3, pseudogene (PTTG3P) biological function colorectal cancer (CRC) further needs to be clarified. qRT-PCR was used measure the PTTG3P level CCK-8, glucose uptake, lactate assay, adenosine triphosphate (ATP) extracellular acidification rate (ECAR) xenograft mice model were adopted evaluate glycolysis proliferation, macrophage...
Herein we describe the design and synthesis of a series pyridopyrazine-1,6-dione γ-secretase modulators (GSMs) for Alzheimer's disease (AD) that achieve good alignment potency, metabolic stability, low MDR efflux ratios, while also maintaining favorable physicochemical properties. Specifically, incorporation fluorine enabled metabolically less liable lipophilic alkyl substituents to increase potency without compromising sp(3)-character. The lead compound 21 (PF-06442609) displayed rodent...
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is an important zoonotic microorganism that increasingly causing public health concern worldwide. The objective of this study was to determine the transmission and occurrence MRSA in a slaughterhouse environment evaluate its antimicrobial resistance genetic characterization. In study, we conducted comprehensive epidemiological survey S. by spa typing whole-genome sequencing (WGS) samples obtained from pork production...
A unique tetrahydrofuran ether class of highly potent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor potentiators has been identified using rational and structure-based drug design. An acyclic lead compound, containing an ether-linked isopropylsulfonamide biphenyl group, was pharmacologically augmented by converting it to a conformationally constrained improve key interactions with the human GluA2 ligand-binding domain. Subsequent replacement distal phenyl motif...
Herein we describe the design and synthesis of a novel series γ-secretase modulators (GSMs) that incorporates pyridopiperazine-1,6-dione ring system. To align improved potency with favorable ADME in vitro safety, applied prospective physicochemical property-driven coupled parallel medicinal chemistry techniques to arrive at containing conformationally restricted core. Lead compound 51 exhibited good ADME, which translated into vivo pharmacokinetic profile. Furthermore, robust reduction brain...
Abstract The synthesis of a new trifluoromethyl oxetane was developed using Corey–Chaykovsky epoxidation/ring‐expansion reaction ketones. shown to proceed under mild conditions and displays broad substrate scope. also evaluated as tert ‐butyl isostere in the context γ‐secretase modulator (GSM) program. We demonstrate that oxetane‐containing GSM has decreased lipophilicity, improved lipophilic efficiency (LipE) metabolic stability relative corresponding analogue, thus highlighting several...
Positive allosteric modulators ("potentiators") of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) enhance excitatory neurotransmission and may improve the cognitive deficits associated with various neurological disorders. The dihydroisoxazole (DHI) series AMPAR potentiators described herein originated from identification 7 by a high-throughput functional activity screen using mouse embryonic stem (mES) cell-derived neuronal precursors. Subsequent...
The association between gallstones or cholecystectomy and the incidence risk of liver cancer is controversial. This a meta-analysis observational studies on role in primary cancer. Relevant were identified after literature search via electronic databases until June 2014. A random-effects model was used to generate pooled multivariable adjusted odds ratios (ORs) 95% confidence intervals (CIs). Heterogeneity among evaluated using Cochran's Q I statistics. total 14 (four case-control, 10...
Herein we describe the discovery of a novel series cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators for treatment Alzheimer's disease (AD). Using ligand-based design tactics such as conformational analysis and molecular modeling, chromane unit was identified suitable heterocyclic replacement naphthyl moiety that present in preliminary lead
Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is an important zoonotic microorganism that increasingly causes public health concern worldwide. The objective of this study was to determine the prevalence and transmission in duck farms evaluate its antimicrobial resistance genetic characteristics.