A5038793620- Lipid Membrane Structure and Behavior
- Advanced NMR Techniques and Applications
- Antimicrobial Peptides and Activities
- Supramolecular Self-Assembly in Materials
- Ion channel regulation and function
- Algal biology and biofuel production
- Silk-based biomaterials and applications
- Bacteriophages and microbial interactions
- Marine Bivalve and Aquaculture Studies
- Photosynthetic Processes and Mechanisms
- Cardiac electrophysiology and arrhythmias
- Bone Tissue Engineering Materials
- Electron Spin Resonance Studies
- DNA and Nucleic Acid Chemistry
- Paleontology and Stratigraphy of Fossils
- Protein Structure and Dynamics
- Aquatic Invertebrate Ecology and Behavior
- RNA and protein synthesis mechanisms
- Metabolomics and Mass Spectrometry Studies
- Probiotics and Fermented Foods
- Polymer Surface Interaction Studies
- Advancements in Transdermal Drug Delivery
- Photoreceptor and optogenetics research
- Calcium Carbonate Crystallization and Inhibition
- Magnetic and Electromagnetic Effects
Université du Québec à Montréal
2015-2024
PROTEO
2019-2023
Downtown Women's Health Care
2020
Université Laval
2003-2019
Centre québécois sur les matériaux fonctionnels
2014
ETH Zurich
2005-2007
Université de Montréal
1995-1996
Abstract Bicelles are an attractive membrane mimetic system because of their planar surface and lipid composition, which resemble biological membranes. In addition, orientation morphologic properties make them amenable to solid‐ solution‐state NMR. This article reviews the physical bicelles, such as magnetic alignment viscosity well different models proposed in literature explain bicelle morphology. The utility bicelles for studying interaction structure peptides proteins by NMR is also...
Bicelles are model membranes generally made of long-chain dimyristoylphosphatidylcholine (DMPC) and short-chain dihexanoyl-PC (DHPC). They extensively used in the study membrane interactions structure determination membrane-associated peptides, since their composition morphology mimic widespread PC-rich natural eukaryotic membranes. At low DMPC/DHPC (q) molar ratios, fast-tumbling bicelles formed which DMPC bilayer is stabilized by DHPC molecules high-curvature rim region. Experimental...
Microalgae are photosynthetic organisms widely distributed in nature and serve as a sustainable source of bioproducts. Their carbohydrate components also promising candidates for bioenergy production bioremediation, but the structural characterization these heterogeneous polymers cells remains formidable problem. Here we present applicable protocol identifying quantifying glycan content using magic-angle-spinning (MAS) solid-state NMR (ssNMR) spectroscopy, with validation from glycosyl...
Microalgae are a renewable and promising biomass for large-scale biofuel, food nutrient production. However, their efficient exploitation depends on our knowledge of the cell wall composition organization as it can limit access to high-value molecules. Here we provide an atomic-level model non-crystalline water-insoluble glycoprotein-rich Chlamydomonas reinhardtii. Using in situ solid-state sensitivity-enhanced nuclear magnetic resonance, reveal unprecedented details protein carbohydrate...
Original glycodendrimers emanating from propargylated hexaphenylbenzene cores and containing up to 54 peripheral sugar ligands have been synthesized by Cu(I)-catalyzed [1,3]-dipolar cycloadditions using both convergent divergent approaches.
The molecular structure of the blue mussel Mytilus edulis whole anchoring threads was studied by two-dimensional 13C solid-state NMR on fully labeled fibers. This unique material proves to be well ordered at a level despite its heterogeneous composition as evidenced narrow measured linewidths below 1.5 ppm. spectra are dominated residues in collagen environments, determined from chemical shift analysis, and complete assignment (including minor amino acids) possible. best agreement between...
Nature is rich with examples of highly specialized biological materials produced by organisms for functions, including defense, hunting, and protection. Along these lines, velvet worms (Onychophora) expel a protein-based slime used hunting defense that upon shearing dehydration forms fibers as stiff thermoplastics. These can dissolve back into their precursor proteins in water, after which they be drawn new fibers, providing inspiration to design recyclable materials. Elevated phosphorus...
We have studied the molecular disorder in (13C)Ala- and (13C)Gly-labeled dragline silk from Nephila edulis through distributions of isotropic chemical shifts one- two-dimensional 13C−13C NMR spectra obtained under MAS. The alanine residues were found to be present two distinct major structural environments, agreement with previous studies, where β-sheets 31-helices found. shift within each residue uncorrelated, even between spins same amino acid residue, similar widths for both crystalline...
The exceptional upconverting properties of lanthanide-doped nanoparticles make them attractive systems with applications ranging from photovoltaics to biological labeling, imaging, and therapeutics. While they draw considerable interest, structural data, which are necessary understand the upconversion process, remain scarce. In this work, we demonstrate use 23Na, 19F, 89Y solid-state NMR together DFT calculations characterize structure cubic NaYF4 without Er3+ doping. By measuring 23Na MAS...
Starch is the most abundant energy storage molecule in plants and an essential part of human diet. This glucose polymer composed amorphous crystalline domains different forms (A B types) with specific physicochemical properties that determine its bioavailability for organism, as well value food industry. Using two-dimensional (2D) high resolution solid-state nuclear magnetic resonance (SS-NMR) on 13C-labelled starches were obtained from Chlamydomonas reinhardtii microalgae, we established a...