A5031389448- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Bone and Joint Diseases
- Dental materials and restorations
- Advanced Sensor and Energy Harvesting Materials
- Orthopaedic implants and arthroplasty
- Planarian Biology and Electrostimulation
- Alkaline Phosphatase Research Studies
- Endodontics and Root Canal Treatments
- Polymer composites and self-healing
- RNA Interference and Gene Delivery
- Conducting polymers and applications
- Nanoplatforms for cancer theranostics
- Retinal Diseases and Treatments
- Mitochondrial Function and Pathology
- Adsorption and biosorption for pollutant removal
- Layered Double Hydroxides Synthesis and Applications
- Sirtuins and Resveratrol in Medicine
- Family Dynamics and Relationships
- Bone health and treatments
- Graphene and Nanomaterials Applications
- Phosphorus and nutrient management
- Intergenerational Family Dynamics and Caregiving
- Orthopedic Infections and Treatments
Xi'an Jiaotong University
2025
Sichuan University
2021-2024
Chengdu University
2021
As a major late complication of diabetes, diabetic peripheral neuropathy (DPN) is the primary reason for amputation. Nevertheless, there are no wonder drugs available. Regulating dysfunctional mitochondria key therapeutic target DPN. Resveratrol (RSV) widely proven to guard mitochondria, yet unsatisfactory bioavailability restricts its clinical application. Tetrahedral framework nucleic acids (tFNAs) promising carriers due their excellent cell entrance efficiency, biological safety, and...
Abstract Background As fertility rates decline and population ageing intensifies, the conflict between career childbearing continues to impact clinicians, especially women. Exploring gender differences in intentions of male female clinicians could help with identifying barriers childbearing, developing effective policies support work-life balance, addressing gap research on disparities this field. Methods We conducted a cross-sectional survey among health care personnel Chinese public...
The deformation shrinkage of electrospun PLGA was affected by Tg, environment temperature and incubated solvent. A heat stretching process could maintain the dimensional structure polyester-based membrane in liquid medium.
Abstract Enzymes play a key role in natural mineralization, but their function is disabling bone metabolism when patients suffer severe degenerations like hypophosphatasia. To regulate homeostasis, self‐activating phosphorus‐rich system proposed on calcium glycerophosphate (CaGP) modified polyurethane (PU) fibrous substrate, wherein ample enzyme catalytic domains are imported with intestinal alkaline phosphatase (IALP) chelating and activating by situ that testified chemical potential...
Abstract Biomaterial-associated infection (BAI) is a kind of serious post-operative complication in orthopaedic surgery. Antibiotic-loaded bone cement shines light on BAI prevention for convenient manipulation and complex filling. To this aim, we designed an antibacterial based Nano-hydroxyapatite/Polyurethane (PUHA) loading with antibiotic Enoxacin (EN). The distinct shear-thinning behavior the prepolymers was observed, indicating good injectability. PUHA possessed suitable curing speed,...
Processibility and biodegradability of conductive polymers are major concerns when they applied to tissue regeneration. This study synthesizes dissolvable aniline trimer-based polyurethane copolymers (DCPU) processes them into scaffolds by using electrospinning with different patterns (random, oriented, latticed). The effects topographic cue changes on electrical signal transmission further regulation cell behaviors concerning bone researched. Results show that DCPU fibrous possessed good...
Doxorubicin (Dox)-loaded or selenium-substituted hydroxyapatite (HA) has been developed to achieve anti-osteosarcoma bone regeneration in a number of studies. However, currently, there is lack studies on the combination Dox and selenium loading in/on HA comparative research which form size are more suitable for drug release treatment osteogenesis after osteosarcoma resection. Herein, selenium-doped rod-shaped nano-HA (n-HA) spherical mesoporous (m-HA) were successfully prepared. The doping...
Inspired by the crucial role of matrix vesicles (MVs), a series biomimetic (BVs) fabricated calcium glycerophosphate (CaGP) modified polyurethane were designed to mediate mineralization through in situ enzyme activation for bone therapy. In this study, alkaline phosphatase (ALP) was harbored porous BVs adsorption (Ad-BVs) or entrapment (En-BVs). High encapsulation ALP on En-BVs effectively self-activating ions CaGP-modified PU that specifically hydrolyzed organophosphorus inorganic...
Combined with a series of antibacterial tests and the genetic assessment apoptotic pathway, an evaluation system has been rationalized to govern fate different compositions PU-based sealers.
Abstract In order to improve the processability of conductive polyurethane (CPU) containing aniline oligomers, a new CPU trimer (AT) and l ‐lysine (PUAT) are designed synthesized. Further, 3D porous PUAT membranes have been prepared by simple gel cooperated with freeze‐drying method. Chemical testings properties testify self‐ doping model based on rich electronic electroaffinity AT moities. The self‐doping behavior further endows copolymers specific characteristics such as high electrical...
There is an urgent need to assess material degradation in situ and real time for their promising application regeneration therapy. However, traditional monitoring methods vitro cannot always profile the complicated behavior vivo. This study designed synthesized a new biodegradable polyurethane (PU-P) scaffold with polycaprolactone glycol, isophorone diisocyanate, l-lysine ethyl ester dihydrochloride. To monitor process of PU-P, calcein was introduced into backbone (PU-5) as chromophore...