A5010688253- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- Neural Networks and Applications
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Ion channel regulation and function
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
New York University
2023-2024
École Polytechnique Fédérale de Lausanne
2015-2021
NYU Langone Health
2021
Columbia University
2013
Howard Hughes Medical Institute
2010
Calcium imaging for observing spiking activity from large populations of neurons are quickly gaining popularity. While the raw data fluorescence movies, underlying spike trains interest. This work presents a fast non-negative deconvolution filter to infer approximately most likely train each neuron, given observations. algorithm outperforms optimal linear (Wiener filtering) on both simulated and biological data. The performance gains come restricting inferred be positive (using an...
Goal-directed sensorimotor transformation drives important aspects of mammalian behavior. The striatum is thought to play a key role in reward-based learning and action selection, receiving glutamatergic signals dopaminergic reward signals. Here, we obtain whole-cell membrane potential recordings from the dorsolateral mice trained lick spout after whisker deflection. Striatal projection neurons showed strong task-related modulation, with more depolarization firing on hit trials compared...
Inhibitory GABAergic interneurons have been extensively studied but their contribution to circuit dynamics remain poorly understood. Although it has suggested that interneurons, especially those belonging the same subclass, synchronize activity and impart this synchrony onto local network, recent theoretical experimental work challenged view. To better understand of during cortical activity, we combined molecular identification, two-photon imaging, electrophysiological recordings in...
The posterior "tail" region of the striatum receives dense innervation from sensory brain regions and has been demonstrated to play a role in behaviors that require sensorimotor integration including discrimination
Abstract The striatum integrates sensorimotor and motivational signals, likely playing a key role in reward-based learning of goal-directed behavior. However, cell type-specific mechanisms underlying reinforcement remain to be precisely determined. Here, we investigated changes membrane potential dynamics dorsolateral striatal neurons comparing naïve mice expert trained lick reward spout response whisker deflection. We recorded from three distinct types: (i) direct pathway striatonigral...