A5071879130- Biochemical Acid Research Studies
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Neurosurgical Procedures and Complications
- Diet, Metabolism, and Disease
- Microbial Fuel Cells and Bioremediation
- Cholesterol and Lipid Metabolism
- Electrochemical sensors and biosensors
- Intracerebral and Subarachnoid Hemorrhage Research
- Eicosanoids and Hypertension Pharmacology
- Lipoproteins and Cardiovascular Health
- Biotin and Related Studies
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Wastewater Treatment and Nitrogen Removal
- Muscle metabolism and nutrition
National Yunlin University of Science and Technology
2019
National Defense Medical Center
2017
University at Buffalo, State University of New York
2013-2015
Inflammatory responses significantly contribute to neuronal damage and poor functional outcomes following intracerebral hemorrhage (ICH). Soluble epoxide hydrolase (sEH) is known induce neuroinflammatory via degradation of anti-inflammatory epoxyeicosatrienoic acids (EET), sEH upregulated in response brain injury. The present study investigated the involvement ICH-induced neuroinflammation, damage, deficits using a mouse ICH model microglial cultures.ICH was induced by injecting collagenase...
We characterized the hypolipidemic effects of alpha-lipoic acid (LA, R-form) and examined associated molecular mechanisms in a high fat fed Zucker rat model. Rats (n = 8) were assigned to (HF) diet or HF with 0.25% LA (HF-LA) for 30 days pair remove confounding anorectic properties LA. Compared controls, HF-LA group was protected against diet-induced obesity (102.5±3.1 vs. 121.5±3.6,% change BW) hypercholesterolemia reduction total-C (−21%), non-HDL-C (−25%), LDL-C (−16%), total LDL particle...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a novel biomarker of LDL clearance and therapeutic target cardiovascular disease. We examined the effects aerobic exercise training in modulating PCSK9 abundance hepatic sterol regulation high-fat-fed C57BL/6 mice. Mice (<svg style="vertical-align:-0.1638pt;width:36.237499px;" id="M1" height="11.125" version="1.1" viewBox="0 0 36.237499 11.125" width="36.237499" xmlns:xlink="http://www.w3.org/1999/xlink"...
To investigate the cholesterol-lowering effectiveness of a phytosterol/α-lipoic acid (PS/αLA) therapy, thirty-two male Zucker rats were randomly assigned to 1 4 diets for 30 days: (i) high fat diet (HF, 40% energy from fat); (ii) HF supplemented with 3% phytosterols; (iii) 0.25% αLA; or (iv) PS (3%) and αLA (0.25%, PS/αLA). Compared diet, combination PS/αLA proved more effective in reducing non-HDL cholesterol (−55%) than either (−24%) (−25%) therapies alone. supplementation did not affect...
Alpha‐lipoic acid (LA) possesses hypocholesterolemic properties; however, the underlying molecular mechanisms have not been fully elucidated. We examined effects of LA supplementation on blood cholesterol, lipoprotein distribution, and hepatic cholesterol homeostasis in a high fat fed Zucker rat model driven by both genetic predisposition diet induction toward obesity dyslipidemia. Rats (n=8) were assigned to (HF) or HF with 0.25% (HF‐LA) for 30 days. LA‐supplementation protected against...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a novel biomarker of LDL clearance and potential therapeutic target cardiovascular disease risk. Our objective was to examine the effects aerobic exercise training in modulating PCSK9 metabolism hepatic sterol regulation high fat fed C57Bl/6 mouse. Mice (n=8) were randomly assigned diet (HF) or with (HFE) group for 8 weeks. The HFE progressively trained 5 days/week on motorized treadmill (up 5% grade, 45 min/day, 26 m/min). Endpoint...