Preeclampsia is a severe disorder of human pregnancy characterized by generalized activation maternal endothelial cells. Oxidative stress the placenta considered key intermediary step, precipitating deportation apoptotic fragments into circulation, but cause remains unknown. We hypothesize that intermittent placental perfusion, secondary to deficient trophoblast invasion endometrial arteries, leads an ischemia-reperfusion–type insult. therefore tested whether hypoxia-reoxygenation (H/R) in...

Oxidative stress is a prominent feature of the placenta in many complications pregnancy, such as preeclampsia. The cause primarily unknown, although ischemia-reperfusion injury one possible mechanism. Our aim was to test this hypothesis by examining oxidative status human placental tissues during periods hypoxia and reoxygenation vitro. Rapid generation reactive oxygen species detected using fluorogenic probe, 2′,7′-dichlorofluorescein diacetate, when hypoxic were reoxygenated. principal...

Background Unexplained intrauterine growth restriction (IUGR) may be a consequence of placental insufficiency; however, its etiology is not fully understood. We surmised that defective placentation in IUGR dysregulates cellular bioenergic homeostasis, leading to increased autophagy the villous trophoblast. The aims this work were (1) compare differences autophagy, p53 expression, and apoptosis between placentas women with normal or pregnancies; (2) study effects hypoxia role regulating...

To investigate the associations between maternal pregestational body mass index (BMI), gestational weight gain (GWG), and adverse pregnancy outcomes among Taiwanese women.A retrospective cohort study was conducted all singletons without fetal anomalies delivered to women at Taipei Chang Gung Memorial Hospital 2009 2015. Two cohorts were selected for analysis: deliveries after 24 0/7 weeks of gestation (Cohort 1, n=12,064) live births 37 excluding overt diabetes mellitus chronic hypertension...

BackgroundAutophagy has been reported to be essential for pre-implantation development and embryo survival. However, its role in placental regulation of autophagy during pregnancy remain unclear. The aims this study were (1) by characterizing changes levels beclin-1, DRAM, LC3B human placenta throughout gestation; (2) determine whether is involved trophoblast invasion JEG-3 cells (a choriocarcinoma cell line); (3) examine the effects reduced oxygen glucose on autophagic changes; (4)...

Tropomyosin-related kinase B (TrkB) signaling is critical for promoting neuronal survival following brain damage. The present study investigated the effects and underlying mechanisms of TrkB activation by agonist 7,8-dihydroxyflavone (7,8-DHF) on traumatic injury (TBI). Mice subjected to controlled cortical impact received intraperitoneal 7,8-DHF or vehicle injection 10 min post-injury subsequently daily 3 days. Behavioral studies, histology analysis water content assessment were performed....

Abstract Objective This study investigated the effects of mobile health application designed based on mindfulness and social support theory parenting self-efficacy postpartum depression symptoms puerperae. Methods We recruited 130 puerperae from a hospital in China randomized them to an App use group (n = 65) waiting control 65). The underwent 8-week app intervention while no intervention. measured four main variables (mindfulness, perceived support, maternal parental depressive symptoms)...

To identify risk factors associated with placenta accreta in a large cohort study.Data for this study came from the Taiwan Down Syndrome Screening Group, an ongoing project on feasibility of serum screening Asian population. Women who had syndrome at 14-22 weeks' gestation using alpha-fetoprotein (AFP) and free beta-hCG between January 1994 June 1997, delivered same institution, were included (n = 10,672). Those multiple gestations 200), overt diabetes 11), or fetal malformations 101)...

Traumatic brain injury (TBI) triggers a series of neuroinflammatory processes that contribute to evolution neuronal injury. The present study investigated the neuroprotective effects and anti-inflammatory actions berberine, an isoquinoline alkaloid, in both vitro vivo TBI models. Mice subjected controlled cortical impact were injected with berberine (10 mg·kg−1) or vehicle 10 min after In addition behavioral studies histology analysis, blood-brain barrier (BBB) permeability water content...

Background Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to neuronal damage and behavioral impairment. This study was undertaken investigate the effects of wogonin, flavonoid with potent anti-inflammatory properties, on functional histological outcomes, edema, toll-like receptor 4 (TLR4)- nuclear factor kappa B (NF-κB)-related signaling pathways in mice following TBI. Methodology/Principal Findings Mice subjected controlled cortical impact were injected...

Background Traumatic brain injury (TBI) induces a complex sequence of apopototic cascades that contribute to secondary tissue damage. The aim this study was investigate the effects salidroside, phenolic glycoside with potent anti-apoptotic properties, on behavioral and histological outcomes, edema, apoptosis following experimental TBI possible involvement phosphoinositide 3-kinase/protein kinase B (PI3K)/Akt signaling pathway. Methodology/Principal Findings Mice subjected controlled cortical...

Inflammatory responses significantly contribute to neuronal damage and poor functional outcomes following intracerebral hemorrhage (ICH). Soluble epoxide hydrolase (sEH) is known induce neuroinflammatory via degradation of anti-inflammatory epoxyeicosatrienoic acids (EET), sEH upregulated in response brain injury. The present study investigated the involvement ICH-induced neuroinflammation, damage, deficits using a mouse ICH model microglial cultures.ICH was induced by injecting collagenase...

The frequent occurrence of multidrug resistance (MDR) conferred by the overexpression ATP-binding cassette (ABC) transporters ABCB1 and ABCG2 in cancer cells remains a therapeutic obstacle for scientists clinicians. Consequently, developing or identifying modulators that are suitable clinical practice is great importance. Therefore, we have explored drug repositioning approach to identify candidate from tyrosine kinase inhibitors with known pharmacological properties anticancer activities....

Intracerebral hemorrhage (ICH) induces a series of inflammatory processes that contribute to neuronal damage and neurological deterioration. Liver X receptors (LXRs) are nuclear negatively regulate transcriptional involved in responses, but their role the pathology following ICH remains unclear. The present study investigated neuroprotective effects anti-inflammatory actions TO901317, synthetic LXR agonist, model collagenase-induced microglial cultures. Mice subjected injury were injected...

Background In 2010, the International Association of Diabetes and Pregnancy Study Groups (IADPSG) recommended a new strategy for screening diagnosis gestational diabetes mellitus (GDM). However, no study has indicated that adopting IADPSG recommendations improves perinatal outcomes. The objective this was to evaluate effects implementing criteria diagnosing GDM on maternal neonatal Methodology/Principal Findings Previously, we used two-step approach (a 1-h, 50-g glucose challenge test...

Intracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades that contribute to secondary neuronal damage. Tropomyosin-related kinase receptor B (TrkB) signaling plays crucial role in promoting survival following brain The present study investigated the protective effects and underlying mechanisms TrkB activation by specific agonist, 7,8-dihydroxyflavone (7,8-DHF), model collagenase-induced ICH cultures. Mice subjected were intraperitoneally injected with either 7,8-DHF or...