A5029575999- Conducting polymers and applications
- Cellular Mechanics and Interactions
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Smart Grid and Power Systems
- Synthesis and characterization of novel inorganic/organometallic compounds
- Power Systems and Technologies
- Electrochemical Analysis and Applications
- Wound Healing and Treatments
- Silicone and Siloxane Chemistry
- Metabolism, Diabetes, and Cancer
- Electrochemical sensors and biosensors
- Organoboron and organosilicon chemistry
- Zebrafish Biomedical Research Applications
- Pancreatic function and diabetes
- Biochemical Acid Research Studies
- Muscle metabolism and nutrition
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Clostridium difficile and Clostridium perfringens research
- Advanced biosensing and bioanalysis techniques
- Advanced Data and IoT Technologies
- DNA and Biological Computing
- Advancements in Transdermal Drug Delivery
- Child and Adolescent Psychosocial and Emotional Development
China Southern Power Grid (China)
2022-2024
Waseda University
2022-2024
Shanghai Jiao Tong University
2023
Nanyang Technological University
2015-2020
Novartis (United States)
2019
Minzu University of China
2019
Zhejiang University
2008-2016
University at Buffalo, State University of New York
2014-2015
Xihua University
2015
Massachusetts General Hospital
2015
Abstract Bacterial infections remain a leading threat to global health because of the misuse antibiotics and rise in drug‐resistant pathogens. Although several strategies such as photothermal therapy magneto‐thermal can suppress bacterial infections, excessive heat often damages host cells lengthens healing time. Here, localized thermal managing strategy, thermal‐disrupting interface induced mitigation (TRIM), is reported, minimize intercellular cohesion loss for accurate antibacterial...
Astragalus membranaceus is an important medicinal plant widely cultivated in East Asia. MicroRNAs (miRNAs) are endogenous regulatory molecules that play essential roles growth, development, and the response to environmental stresses. Cold one of key factors affecting yield quality A. membranaceus, miRNAs may mediate gene regulation network under cold stress membranaceus. To identify reveal their functions small RNA sequencing was conducted followed by bioinformatics analysis, quantitative...
We characterized the hypolipidemic effects of alpha-lipoic acid (LA, R-form) and examined associated molecular mechanisms in a high fat fed Zucker rat model. Rats (n = 8) were assigned to (HF) diet or HF with 0.25% LA (HF-LA) for 30 days pair remove confounding anorectic properties LA. Compared controls, HF-LA group was protected against diet-induced obesity (102.5±3.1 vs. 121.5±3.6,% change BW) hypercholesterolemia reduction total-C (−21%), non-HDL-C (−25%), LDL-C (−16%), total LDL particle...
Although aberrant mTORC1 signaling has been well established in models of obesity, little is known about its repressor, REDD1. Therefore, the initial goal this study was to determine role REDD1 on obese skeletal muscle. expression (protein and message) (S6K1, 4E-BP1, raptor-mTOR association, Rheb GTP) were examined lean vs. ob/ob wild-type (WT) knockout (KO) mice, under conditions altered nutrient intake [fasted fed or diet-induced obesity (10% 60% fat diet)]. Despite higher (P < 0.05) S6K1...
The role of biophysical induction methods such as cell micropatterning in stem differentiation has been well documented previously. However, the underlying mechanistic linkage engineered shape to directed lineage commitment remains poorly understood. Here, it is reported that plays an important regulating optimal cytoskeletal tension development human mesenchymal (hMSC) via mechanotransduction pathways induce cardiomyogenic differentiation. Cells are grown on fibronectin strip patterns...
Re-epithelialization by collective migration of epithelial cells over a heterogeneous environment to restore tissue integrity and functions is critical for development regeneration. Here, it reported that the spatial organization adjacent adherent paths within sparsely distributed extracellular matrix (ECM) has significant impact on orientational coupling between cell polarization migration. This effect determines pattern human keratinocytes regain their cohesion, which impacts occupancy...
Abstract Nervous system (NS) development relies on coherent upregulation of extensive sets genes in a precise spatiotemporal manner. How such transcriptome-wide effects are orchestrated at the molecular level remains an open question. Here we show that 3′-untranslated regions (3′ UTRs) multiple neural transcripts contain AU-rich cis -elements (AREs) recognized by tristetraprolin (TTP/Zfp36), RNA-binding protein previously implicated regulation mRNA stability. We further demonstrate...
Abstract The mammalian target of rapamycin (mTOR) signaling pathway is hyperactive in liver, adipose and skeletal muscle tissues obese rodents. Alpha‐lipoic acid (αLA) has been well accepted as a weight‐loss treatment, though there are limited studies on its effect mTOR high‐fat fed, Therefore, the goal this study was to determine oxidative protein alterations rats after αLA supplementation. Phosphorylation substrate, eukaryotic initiation factor (eIF) 4E‐binding 1 (4E‐BP1) eIF4B were...
Abstract Local mechanical cues can affect crucial fate decisions of living cells. Transepithelial stress has been discussed in the context epithelial monolayers, but lack appropriate experimental systems leads current studies to approximate it simply as an in‐plane stress. To evaluate possible contribution force vectors acting other directions, double epithelium a 3D‐printed “GeminiChip” containing sessile and pendant channel is reconstituted. Intriguingly, epithelia prone apoptotic cell...
Appropriate activation of growth signaling pathways, specifically mammalian target rapamycin complex 1 (mTORC1), is central to muscle mass and metabolism. The goal these studies was examine the effects metformin on mTORC1 in aged skeletal an attempt normalize signaling.Aged (23m) young (3m) male mice were fed a low fat diet without or with 0.5% for up 8 weeks, then mTORC1-related examined plantar flexor complex.Metformin had no significant effect lowering body weight animals, nor altered p70...
Abstract Collective behaviors of groups animals, such as schooling and shoaling fish, are central to species survival, but genes that regulate these activities not known. Here we parsed collective behavior adult zebrafish using computer vision unsupervised machine learning into a set highly reproducible, unitary, several hundred millisecond states transitions, which together can account for the entirety relative positions postures fish. Using CRISPR-Cas9 then targeted knockout 35 associated...
In response to increasing power supply needs, maintaining stable substations is vital for reliable electricity. Traditional manual equipment inspections in these are inefficient and risky, often leading hazards delayed detection of faults. Therefore, there's a growing shift towards using intelligent image recognition technology video surveillance systems safer more efficient inspections. This paper focuses on enhancing the level inspection artificial intelligence‐based visual technology. It...
This study explored whether infants understand information transmission in a third‐party communication context involving multiple agents. Infants aged 12 and 15 months were habituated to two agents pursuing different objects then tested with one agent (the communicator) interacting new recipient), whereas the other noncommunicator) did not interact anyone. Results showed that 15‐month‐olds looked for longer when recipient reached toward preferred object of noncommunicator contrast...
Behavioural inhibition influences the development of behavioural regulation in early childhood. Previous studies have mainly focused on relationship between and Don't context (e.g., inhibitory control), while few investigated this Do task persistence). This longitudinal study examined effect temperamental during both contexts 112 Chinese preschoolers. At 3.5 years age, children's was assessed by observation parental report, then at 4.5 their regulatory behaviours were measured following two...
Abstract A synthetic route to polysilaethers containing moiety SiH bonds in the side chain (PSEMH) is reported that allows access hitherto inaccessible oxygen‐interrupt polysilanes. By a Wurtz reductive coupling reaction, an equimolar ratio of dichloromethylsilane alkali metal yields dichlorodisilane. The alcoholysis resultants situ performed, and polycondensation hydrolysis occurs simultaneously presence small amount N,N ‐(dimethylamino)pyridine. linear polymer monomodal PSEMH with...
To provide a stronger guarantee for the power system's stable operation, improving accuracy of short-term load peak prediction is necessary. This paper proposes model TPA-LSTNet that combines TPA (Temporal Pattern Attention) and LSTNet K-Shape time series clustering method. Firstly, collect external information on corresponding date data, such as daily temperature, humidity, wind direction, whether it holiday, Etc. Secondly, using characteristics high precision efficiency algorithm, cluster...
The rapid development of plug-in hybrid electric vehicles and renewable generation brings new challenges to the secure economic operation power systems. A reactive optimization model based minimizing network loss is established, considering vehicle stochastic charging /discharging uncertain outputs wind turbines. To improve accuracy global searching capability, modified membrane computing (MMC) communication rule, cross transposition rule mutation rewrite proposed. Finally, IEEE-33 nodes...