A5090813152- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Congenital heart defects research
- Neurobiology and Insect Physiology Research
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Aquaculture Nutrition and Growth
- Parasites and Host Interactions
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Blood properties and coagulation
- Neonatal Respiratory Health Research
- Malaria Research and Control
- Single-cell and spatial transcriptomics
- Cellular transport and secretion
- Developmental Biology and Gene Regulation
- Erythrocyte Function and Pathophysiology
- Antimicrobial Peptides and Activities
- RNA Research and Splicing
- Cancer-related gene regulation
- Studies on Chitinases and Chitosanases
- Neurogenesis and neuroplasticity mechanisms
Université Libre de Bruxelles
2014-2022
Uppsala University
2006-2013
Fujian Institute of Oceanography
2001
ABSTRACT We report the first complete genome sequence of a marine invertebrate virus. White spot bacilliform virus (WSBV; or white syndrome virus) is major shrimp pathogen with high mortality rate and wide host range. Its double-stranded circular DNA 305,107 bp contains 181 open reading frames (ORFs). Nine homologous regions containing 47 repeated minifragments that include direct repeats, atypical inverted repeat sequences, imperfect palindromes were identified. This largest animal has been...
Committing the heart The is a complex organ composed of multiple cell types such as cardiomyocytes and endothelial cells. Cardiovascular cells arise from Mesp1 -expressing progenitor Lescroart et al. performed single-cell RNA-sequencing analysis mouse wild-type -deficient cardiovascular at early gastrulation (see Perspective by Kelly Sperling). When was eliminated, embryonic remained pluripotent could not differentiate into progenitors. During gastrulation, different progenitors rapidly...
Abstract Background Transglutaminases (TGases) form a group of enzymes that have many different substrates and among the most well known are fibrin for Factor XIIIa clotting protein in crustaceans. We also found TGase is an abundant hematopoietic tissue (Hpt) cells crayfish hence we studied possible function this enzyme hematopoiesis. Results one proteins Hpt its mRNA expression as activity very high cells, lesser semi-granular hemocytes low granular cells. In cultured tissues, was present...
A novel factor, named crustacean hematopoietic factor (CHF), was identified from a library of suppression subtractive hybridization with the aim to find downstream genes an invertebrate cytokine, astakine 1, in freshwater crayfish Pacifastacus leniusculus. CHF is small cysteine-rich protein (∼9 kDa) high similarity N-terminal region vertebrate CRIM1 containing insulin growth binding variant motif unknown function. found be induced primary cell cultures tissue (Hpt) cells (precursors blood...
Hematopoiesis is the process by which hemocytes mature and subsequently enter circulation. Vertebrate prokineticins (PKs) are known to take part in this process, as invertebrate prokineticin domain proteins, astakines. In Pacifastacus leniusculus, astakine 1 essential for release of new into open circulatory system these animals. addition 1, we have now cloned a homologue with an insert 13 amino acids, named 2. Both crustacean astakines lack N-terminal AVIT motif, present vertebrate PKs,...
During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here, we combine whole-genome transcriptional epigenetic analyses with in vivo functional studies demonstrate that Bcl6, a repressor previously reported promote cortical acts as driver neurogenic transition direct silencing selective repertoire genes belonging multiple pathways promoting self-renewal, most...
During embryonic development, Mesp1 marks the earliest cardiovascular progenitors (CPs) and promotes their specification, epithelial–mesenchymal transition (EMT), differentiation. However, deletion in mice does not impair initial CP specification early cardiac differentiation but induces malformations thought to arise from a defect of migration. Using inducible gain-of-function experiments during stem cell differentiation, we found that Mesp2, its closest homolog, was as efficient at...
During evolution, the innate and adaptive immune systems were developed to protect organisms from non-self substances. The system is phylogenetically more ancient present in most multicellular organisms, whereas responses are restricted vertebrates. Arthropods lack blood cells of lymphoid lineage oxygen-carrying erythrocytes, making them suitable model animals for studying regulation system. Many crustaceans have a long life span need continuously synthesize cells, contrast many insects....
Thymosin proteins are well known for their actin-binding activity. beta 4 (Tβ4) has been associated with biological activities in tissue repair and cell migration via interaction ATP-synthase vertebrates, while the information of similar thymosin functions invertebrates is limited. We have shown previously that present on surface crayfish hematopoietic (HPT) cells, astakine 1 (Ast1, an invertebrate cytokine) was found to interact this β-subunit ATP synthase. Here, we identified five...
Summary During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here we combine whole genome transcriptional epigenetic analyses with in vivo functional studies show that Bcl6, a repressor known promote acts as key driver neurogenic transition direct silencing selective repertoire genes belonging multiple pathways promoting self-renewal, most strikingly Wnt...