A5043835842- Global Cancer Incidence and Screening
- Virus-based gene therapy research
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Cancer Risks and Factors
- Metabolomics and Mass Spectrometry Studies
- Physical Activity and Health
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Viral gastroenteritis research and epidemiology
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- BRCA gene mutations in cancer
- Lung Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Genetic Associations and Epidemiology
University of Calgary
2015-2025
Alberta Health Services
2014-2025
Prevention Institute
2019
Canadian Red Cross Society
2017
University of Alberta
2012-2016
Food & Nutrition
2016
University of New Mexico
2016
Health Sciences Centre
2016
Baker Heart and Diabetes Institute
2014
Division of Cancer Epidemiology and Genetics
2014
Despite the high global prevalence of prostate cancer (PCa), few epidemiologic studies have assessed physical activity in relation to PCa survival. To evaluate different types, intensities, and timing relative A prospective study was conducted Alberta, Canada, a cohort 830 stage II–IV incident cases diagnosed between 1997 2000 with follow-up 2014 (up 17 yr). Prediagnosis lifetime self-reported at diagnosis. Postdiagnosis up three times during follow-up. Cox proportional hazards models...
Few studies have examined the association between physical activity and disease outcomes in breast cancer survivors. Here, we report lifetime total performed prior to diagnosis a population-based sample of A cohort 1,231 women diagnosed with 1995 1997 was followed for minimum 8.3 years any progressions, recurrences new primaries; 10.3 deaths. All treatment follow-up care received abstracted from medical records. Data on including type (occupational, household, recreational) dose (frequency,...
Abstract Background: We postulated that the abundance of various metabolites in blood would facilitate diagnosis pancreatic and biliary lesions, which could potentially prevent unnecessary surgery. Methods: Serum samples from patients with benign hepatobiliary disease (n = 43) cancer 56) were examined by 1H NMR spectroscopy to quantify 58 unique metabolites. Data analyzed “targeted profiling” followed supervised pattern recognition orthogonal partial least-squares discriminant analysis...
Timely diagnosis and classification of colorectal cancer (CRC) are hindered by unsatisfactory clinical assays. Our aim was to construct a blood-based biomarker series using single assay, suitable for CRC detection, prognostication staging.Serum metabolomic profiles adenoma (N=31), various stages (N=320) healthy matched controls (N=254) were analysed gas chromatography-mass spectrometry (GC-MS). A diagnostic model derived orthogonal partial least squares-discriminant analysis (OPLS-DA) on...
Presently, colorectal cancer (CRC) is staged preoperatively by radiographic tests, and postoperatively pathological evaluation of available surgical specimens. However, present staging methods do not accurately identify occult metastases. This has a direct effect on clinical management. Early identification metastases isolated to the liver may enable resection, whereas more disseminated disease be best treated with palliative chemotherapy.Sera from 103 patients adenocarcinoma at same...
<h3>Background:</h3> Prospective cohorts have the potential to support multifactorial, health-related research, particularly if they are drawn from general population, incorporate active and passive follow-up permission is obtained allow access by researchers data repositories. This paper describes Phase I of Alberta9s Tomorrow Project cohort, a broad-based research platform designed investigations into factors that influence cancer chronic disease risk. <h3>Methods:</h3> Adults aged 35-69...
Despite the recent advances made in treatment of multiple myeloma, disease still remains incurable. The oncolytic potential reovirus has previously been shown and is currently phase III clinical trials for solid tumors. We tested hypothesis that can successfully target human myeloma vitro, ex vivo, vivo without affecting hematopoietic stem cell (HHSC) re-population/differentiation a murine model partially recapitulates myeloma.Human lines tumor specimens were exposed to oncolysis mechanisms...
In glioblastoma multiforme (GBM), brain-tumor-initiating cells (BTICs) with cancer stem cell characteristics have been identified and proposed as primordial responsible for disease initiation, recurrence, therapeutic resistance. However, the extent to which individual, patient-derived BTIC lines reflect heterogeneity of GBM remains poorly understood. Here we applied a biology approach compared self-renewal, marker expression, label retention, asymmetric division in 20 lines. Through cluster...
Genome-wide association studies (GWASs) have identified low-penetrance common variants (i.e., single nucleotide polymorphisms, SNPs) associated with breast cancer susceptibility. Although GWASs are primarily focused on single-locus effects, gene-gene interactions epistasis) also assumed to contribute the genetic risks for complex diseases including cancer. While it has been hypothesized that moderately ranked (P value based) weak effects in could potentially harbor valuable information...
In high-dimensional regression models, variable selection becomes challenging from a computational and theoretical perspective. Bayesian regularized via shrinkage priors like the Laplace or spike-and-slab prior are effective methods for in p>n scenarios provided configured adequately. We propose an empirical Bayes configuration using checks prior-data conflict: tests that assess whether there is disagreement parameter information by data. apply our proposed method to LASSO linear model...
Abstract Background First Nations (FN) people in Canada are commonly diagnosed with colorectal cancers. Although has treaty responsibilities to ensure FNs have equitable access quality health services, cancer screening by not been fully assessed. Methods The objectives of our retrospective population-level study that linked multiple administrative databases were investigate differences rates: participation, retention, positivity, follow-up colonoscopy, and invasive detection, as well wait...
ABSTRACT BACKGROUND Dietary intake misreporting is widely acknowledged in nutritional epidemiology. The Goldberg method has been proposed as an option for identifying under-reporters of energy (EI) large-scale epidemiologic studies. However, its implementation remains limited by challenges associated with estimating physical activity levels (PAL), a critical component. OBJECTIVE To quantify the accuracy to classify EI using Sedentary Time and Activity Reporting Questionnaire (STAR-Q)-derived...
Multiple myeloma (MM) is a clonal plasma cell malignancy that accounts for 10-15% of newly diagnosed hematological cancers. Although significant advances have been made in the treatment MM disease still remains incurable. The oncolytic potential reovirus has previously demonstrated by others and us currently phase III clinical trials solid tumors. In addition I trial recently initiated MM. Despite activity, mechanism(s) death caused yet not well elucidated. A comprehensive understanding...
The modified Glasgow Prognostic Score (mGPS) has been reported to be an important prognostic indicator in a number of tumor types, including colorectal cancer (CRC). features the inflammatory state thought accompany elevated C-reactive protein (CRP), key feature mGPS, were characterized patients with liver metastases. Additional mediators that contribute prognosis explored.In sera from 69 metastases, panel 42 quantified as function CRP levels, and disease-free survival. Multivariate...
Abstract Modifiable lifestyle factors, including exercise and activity energy expenditure (AEE), may attenuate the unfavorable health effects of obesity, such as risk factors metabolic syndrome (MetS). However, underlying mechanisms are not clear. In this study we sought to investigate whether metabolite profiles MetS adiposity assessed by body mass index (BMI) central obesity inversely correlated with AEE physical activity. We studied 35 men 47 women, aged 30–60 years, using doubly labeled...
Early diagnosis of colorectal cancer (CRC) simplifies treatment and improves outcomes. We previously described a diagnostic metabolomic biomarker derived from semi-quantitative gas chromatography-mass spectrometry. Our objective was to determine whether quantitative assay additional features, including parts the lipidome could enhance power; there an advantage deriving combined signature with broader representation.The well-characterized Biocrates P150 kit used quantify 163 metabolites in...
Purpose A central aspect of physical activity and sedentary behaviour research is accurate exposure assessment in the context disease outcomes. The primary objectives this study were to evaluate convergent validity test–retest reliability ActiGraph GT3X+ activPAL3 accelerometers. Methods Participants from Breast Cancer Exercise Trial Alberta (n=266) wore both devices concurrently during waking hours for 7 days. Summary measures time (hours/day) compared between using Student’s t-tests....
The Alberta Moving Beyond Breast Cancer (AMBER) Study is an ongoing prospective cohort study investigating how direct measures of physical activity (PA), sedentary behavior (SB), and health-related fitness (HRF) are associated with survival after breast cancer.Women in newly diagnosed stage I (≥ T1c) to IIIc cancer were recruited between 2012 2019. Baseline assessments completed within 90 days surgery. Measurements included accelerometers measure PA SB; a graded treadmill test gas exchange...
Reovirus is a ubiquitous RNA virus that exploits aberrant signaling pathways for its replication. The oncolytic potential of reovirus against numerous cancers under pre-clinical/clinical conditions has been documented by us and others. Despite proven clinical activity, the underlying mechanisms oncolysis still not well elucidated. If therapy to be optimized cancer, including breast cancer patients, it imperative understand oncolysis, especially in treatment resistant tumour.In present study...