A5052985957- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Injury Epidemiology and Prevention
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Systemic Lupus Erythematosus Research
- Hippo pathway signaling and YAP/TAZ
- Transportation and Mobility Innovations
- Technology and Data Analysis
- Cytomegalovirus and herpesvirus research
- Traffic and Road Safety
- Human-Automation Interaction and Safety
- Evacuation and Crowd Dynamics
- Light effects on plants
- Hematopoietic Stem Cell Transplantation
- Kruppel-like factors research
- Consumer Perception and Purchasing Behavior
- Quality and Safety in Healthcare
- Software System Performance and Reliability
- Occupational Health and Performance
- Inflammatory Biomarkers in Disease Prognosis
- Magnetic and Electromagnetic Effects
Yonsei University
2013-2023
Abstract Regulatory T (Treg) cells act as terminators of cell immuniy during acute phase viral infection; however, their role and suppressive mechanism in chronic infection are not completely understood. In this study, we compared the phenotype function Treg or with lymphocytic choriomeningitis virus. Chronic infection, unlike led to a large expansion upregulation programmed death-1 (PD-1). from chronically infected mice (chronic cells) displayed greater capacity for inhibiting both CD8+...
<h3>Background</h3> Regulatory T (T<sub>reg</sub>) cells have an immunosuppressive function in cancer, but the underlying mechanism of immunosuppression tumor microenvironment (TME) is unclear. <h3>Methods</h3> We compared phenotypes cell subsets, including T<sub>reg</sub> cells, obtained from peripheral blood, malignant effusion, and tumors 103 cancer patients. Our primary focus was on expression immune checkpoint (IC)-molecules, such as programmed death (PD)-1, T-cell immunoglobulin...
Abstract Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression used to predict anti-PD-1 therapy responses in NSCLC, its accuracy relatively less. Therefore, we sought identify more accurate predictive blood biomarker evaluating response. We evaluated the frequencies T cells, B natural killer (NK) polymorphonuclear myeloid-derived...
Regulatory T cells (Treg) are enriched in the tumor microenvironment (TME) and suppress antitumor immunity; however, molecular mechanism underlying accumulation of Tregs TME is poorly understood. In various models, tumor-infiltrating were highly had significantly higher expression immune checkpoint molecules. To characterize Tregs, we performed bulk RNA sequencing (RNA-seq) found that proliferation-related genes, suppression-related cytokine/chemokine receptor genes upregulated compared with CD4
// Vijayendra Agrawal 1 , Sony Maharjan Kyeojin Kim 2 Nam-Jung 3 Jimin Son Keunho Lee Hyun-Jung Choi Seung-Sik Rho Sunjoo Ahn 4 Moo-Ho Won 5 Sang-Jun Ha Gou Young Koh 6 Young-Myeong 7 Young-Ger Suh and Young-Guen Kwon Department of Biochemistry, College Life Science Biotechnology, Yonsei University, Seoul 120-749, Republic Korea, Pharmacy, National 599 Gwanak-ro, Gwanak-gu, 151-742, Kyung Hee 130-701, Korea Research Institute Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon...
Regulatory T cells (Tregs) are enriched in the tumor microenvironment and play key roles immune evasion of cancer cells. Cell surface markers specific for tumor-infiltrating Tregs (TI-Tregs) can be effectively targeted to enhance antitumor immunity used stratification immunotherapy outcomes. Here, we present a systems biology approach identify functional cell TI-Tregs. We selected differentially expressed genes proteins TI-Tregs compared these with other CD4+ using bulk RNA-sequencing data...
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a core enzyme of the aerobic glycolytic pathway with versatile functions and associated cancer development. Recently, Kornberg et al . published detailed correlation between GAPDH di
During virus infection, T cells must be adapted to activation and lineage differentiation states via metabolic reprogramming.Whereas effector CD8 + preferentially use glycolysis for their rapid proliferation, memory utilize oxidative phosphorylation homeostatic maintenance.Particularly, enhanced AMP-activated protein kinase (AMPK) activity promotes the cell response through different pathways.However, level of AMPK required optimal remains unclear.A new metformin derivative, IM156, formerly...
BACKGROUND:The poor ergonomic design of patient monitoring systems can cause user errors and harm. This paper presents the results a comparative usability study based on experience preference survey. MATERIAL AND METHODS:We conducted 3 systems: Mediana M50, Philips IntelliVue MP70, MX700. Thirty-nine Coronary Care Unit nurses 19 Pulmonology Allergy participated in this study. User was assessed with Post-Study System Usability Questionnaire National Aeronautics Space Administration Task Load...
CD80 is mainly expressed on Ag-presenting cells (APCs) as a costimulatory molecule but also detected T cells. However, the origin and physiological role of CD8+ remain unclear. In present study, we demonstrated that effector memory cells, not naïve displayed molecules their surfaces after acute lymphocytic choriomeningitis virus infection. Using adoptive transfer CD80-knockout (KO) into wild type or CD80-KO recipient, by both intrinsic expression extrinsic acquisition, while only...
Abstract Regulatory T cells (T regcells) are responsible for immune homeostasis and highly express PD-1 in the tumor microenvironment (TME). However, role of tumor-infiltrating (TI) regcells remains controversial. Indeed, expression was even higher than CD8 +T conventional CD4 cells. Here, we identified that conditional deletion delayed growth by reducing TI regcell pool amplifying functionality +and In Pdcd1 fl/flFoxp3 eGFP-Cre-ERT2(+/−)mice, which both WTand KOT coexisted, exhibited...
Objective: This study aims to investigate the relationship between waist circumference and work-related injury in reference fourth Korea National Health Nutrition Examination Survey.Methods: By analyzing data from Survey conducted 2007 2009, we estimated rate of experience according socioeconomic status, including occupational property, 8,261 subjects.We performed logistic regression analysis with as dependent variable an independent variable, Odds ratios (OR) were calculated, which reflect...
Abstract Purpose: Regulatory T (Treg) cells perform the immune suppressive function in cancer, but their mechanism tumor microenvironment (TME) has not been clearly elucidated. We aim to identify phenotype and functional of Treg TME from cancer patients. Experimental Design: collected 72 malignant effusion (ME) peripheral blood (PB) specimens stage IV patients 10 tissue (TM) PB lung who underwent surgery. Lymphocytes ME, TM, were analyzed for subtype Tconv cells, expressions checkpoint (IC)...
Different qualities of supplemental light emitting diode (LED) were applied to enhance growth characteristics and bioactive compounds buckwheat (Fagopyrum esculentum) seedlings.
작가 최선은 2020년 8월부터 <코로나 위장> 연작을 전시하기 시작한다. 그는 팬데믹 시대가 연상시킨 과거에 경험된 분위기들을 상징하는 문양들을 결합하여 ‘코로나 위장’ 문양을 제작하고, 이 빨간색으로 하얀 캔버스, 우의, 천, 자신의 자가용, 플라스틱 연질필름과 같은 바탕에 삽입하였다. 작업 전반을 ‘분위기의 시각화’라 칭한다. 여기서 ‘시각화’는 그가 체험한 미적 경험에서 실천으로서의 표현으로 이행하는 구체화 과정을 가리키며, “2020년 코로나 사태를 떠올리게 할 수 있는 그림을 그릴 있는가?”라는 그의 질문에서 비롯된다. 이것이 불가능하다는 결론을 내리게 되는데, 그 이유는 자신이 관객과 갖는 이해의 간극을 ‘한 시대를 사는 사람’이 보편적 한계로 받아들이고 있기 때문이다. 이에 간극의 근원에 대한 물음들을 제기하게 되고, 물음들은 예술적 실천의 뿌리를 이루고 있다. 이러한 한계에도 불구하고 작가가 위 작업의 목적에 대해 “일상의 움직임들이 멈춰버리자 그것으로 인한...