A5016760790- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Cell Adhesion Molecules Research
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
Yonsei University
2022-2024
Abstract Background Oncolytic viruses are being studied and developed as novel cancer treatments. Using directed evolution technology, structural modification of the viral surface protein increases specificity oncolytic virus for a particular cell. Newcastle disease (NDV) does not show certain types cells during infection; therefore, it has low cell specificity. Hemagglutinin is an NDV receptor-binding on that determines host tropism. selectivity specific can be increased by artificial amino...
Lupus is characterized by the autoantibodies against nuclear Ags, underscoring importance of identifying B cell subsets driving autoimmunity. Our research focused on mitochondrial activity and CXCR4 expression in CD11c
Although recent studies have demonstrated a proinflammatory effect of extracellular histones in sepsis via endothelial cytotoxicity, little is known about their contribution to autoimmune arthritis. Therefore, we investigated the role arthritis and cytotoxic on synoviocytes macrophages. We measured synovial fluid patients with rheumatoid (RA) evaluated severity serum-transfer (STA) mouse model intraperitoneal histone injection. Histone-induced cytotoxicity was using SYTOX green staining...
<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the overproduction of autoantibodies. Recent studies showed that CD11c+ extrafollicular (EF) B-cells plays central role for development lupus. We investigated mitochondria in EF B cells and plasmablasts <h3>Methods</h3> cells, B6 mice stimulated with CpG-Oligodeoxyribonucleotides (ODN) every other day 10 days. Immune cell subtypes were analyzed flow cytometry. Mitochondria membrane...
Abstract Background TRAIL is an anticancer drug that induces cancer cell apoptosis by interacting with death receptors (DRs). However, owing to low cell‐surface expression of DRs, certain colorectal (CRC) cells resist TRAIL‐induced apoptosis. Newcastle disease virus (NDV) infection can elevate DR protein in cells, potentially influencing their sensitivity. the precise mechanism which NDV modulates and impacts sensitivity remains unknown. Methods Herein, we developed nonpathogenic VG/GA...