A5081047146- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer and Skin Lesions
- Sarcoma Diagnosis and Treatment
- Mesenchymal stem cell research
- CNS Lymphoma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Lung Cancer Research Studies
- Soft tissue tumor case studies
- Urologic and reproductive health conditions
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Vascular Malformations and Hemangiomas
- Hedgehog Signaling Pathway Studies
- Tendon Structure and Treatment
- Elbow and Forearm Trauma Treatment
- Model-Driven Software Engineering Techniques
- Nonmelanoma Skin Cancer Studies
- Transplantation: Methods and Outcomes
- Barrier Structure and Function Studies
- Nerve injury and regeneration
- Ovarian cancer diagnosis and treatment
- COVID-19 diagnosis using AI
- CAR-T cell therapy research
Cooper University Hospital
2025
Cooper University Health Care
2024
Temple University
2019-2024
Cooper Medical School of Rowan University
2024
Philadelphia University
2021-2024
Temple University Hospital
2019-2024
Temple College
2019-2023
Newark Academy
2021
University of Minnesota Rochester
2021
Texas Oncology
2021
ABSTRACT Background and objective Analysis of programmed death ligand‐1 (PD‐L1) in tumour samples is necessary to identify candidates for anti‐PD‐L1/PD‐L1 therapy. Because PD‐L1 evaluated by immunohistochemistry (IHC), an adequate amount tissue a prerequisite testing. To examine whether pleural fluid might be alternative biopsy/resection specimens IHC evaluation patients with non‐small cell lung carcinoma (NSCLC), we compared between histological matched fluid. Methods A retrospective cohort...
Introduction: Pilomatrixomas are benign neoplasms derived from hair follicle matrix cells. They among the most common soft tissue head and neck tumors of childhood. typically isolated, slow-growing, firm, nontender masses that adherent to epidermis but mobile in subcutaneous plane. This clinical presentation is so characteristic many experienced surgeons will excise suspected pilomatrixomas without prior imaging. We reviewed results this approach determine whether physical examination alone...
HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) lead to poor graft survival. Increasing data exist support involvement non-HLA in triggering an immunological response. The development specific for AT1R is associated with clinical outcomes orthotopic heart recipients. This case presents investigation a 56-year-old female recipient diagnosed AMR absence DSAs.
We describe a rapid and efficient 5-step program of defined factors for the genesis brain myelin-forming oligodendrocytes (OLs) from embryonic stem cells (ESCs). The OLs emerge on same time frame in vitro as seen vivo. Factors promoting neural induction (retinoids, noggin) are required, while exogenous Sonic hedgehog is not. In contrast we were unable to generate by trans-differentiation ethically neutral mesenchymal cells, indicating requirement cis-differentiation via ectoderm OL genesis....
Limited literature is available on the tumor microenvironment (TM) of upper tract urothelial carcinoma (UTUC). This study comprehensively reviews programmed death 1 receptor (PD-1)-positive and CD8+ tumor-infiltrating lymphocytes (TILs) ligand (PD-L1) expression epithelium (TE).Seventy-two nephroureterectomy specimens were analyzed for PD-L1, PD-1, CD8. One percent or more lymphohistiocyte PD-L1 was considered positive. TIL density by H&E scored semiquantitatively from 0 to 3, PD-1+ TILs...
Persistent antigen exposure leads to the accumulation of lymphocytes and subsequent tertiary lymphoid structures (TLS). We investigated relationship tumor microenvironment (TME) with respect programmed death ligand 1 (PD-L1), its receptor (PD-1), TLS in upper tract urothelial carcinoma (UTUC) cases compared them UTUC associated bladder (UTUC-BCa).We retrospectively identified 72 patients UTUC. Representative slides were reviewed, counted. Immunohistochemical stains for PD-1 PD-L1 performed....
Objective Interest in immune therapies has exploded since the 2014 approval of first‐generation programmed cell death 1 blocking antibodies for use advanced melanoma. Clinical trials have focused primarily on histological material as gold standard evaluating ligand ( PD ‐L1) by immunoperoxidase IPOX ) studies. Studies validating cytological specimens assessment ‐L1 staining are needed to optimise tissue utilisation complementary diagnostic testing. Methods Twenty‐three melanoma surgical...
Tenosynovial giant cell tumor (TGCT) is a rare type of neoplasm that may be locally aggressive but most often benign and can divided into two subtypes: localized diffuse. It tends to develop in the joints, bursae, tendon sheaths primarily digits hand less commonly forefoot. This soft-tissue mass has many possible differential diagnoses, including lipoma, ganglion cyst, plantar fibroma, various sarcomas; surgical excision usually indicated reach definitive diagnosis rule out malignancy. We...
Bacillary angiomatosis is a vasoproliferative neoplasm primarily seen in immunocompromised individuals. There are overlapping clinical and histopathologic manifestations of bacillary angiomatosis, Kaposi sarcoma, pyogenic granuloma. Distinguishing an accurate diagnosis between these entities utilizing clinical, histopathologic, molecular analysis becomes significant as prognosis treatment differ. Here, we describe case masquerading sarcoma granuloma also highlight unusual presentations the...
We present a patient with giant bilateral perinephric masses favored to represent liposarcoma preoperatively. Bilateral renal involvement posed clinical challenge; careful histologic assessment and surgical planning allowed preservation of function.
Abstract Background: A diagnosis of neuroendocrine tumor (NET) is challenging, but critical, bearing serious implications concerning treatment and prognosis. Case Report: We describe a 39-year-old female presented with 2 weeks increasing right leg pain preventing her from ambulating. She had 6 month-long history nausea, vomiting, weight loss. Lab investigations showed hypercalcemia (13.1 mg/dl) extremely elevated PTH (>2000 pg/ml). Differential included primary hyperparathyroidism, as...